{"data":{"id":"10.6084/m9.figshare.3422083","type":"dois","attributes":{"doi":"10.6084/m9.figshare.3422083","prefix":"10.6084","suffix":"m9.figshare.3422083","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Bracht, John R.","nameType":"Personal","givenName":"John R.","familyName":"Bracht","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Xing","nameType":"Personal","givenName":"Xing","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Keerthi Shetty","affiliation":[],"nameIdentifiers":[]},{"name":"Chen, Xiao","nameType":"Personal","givenName":"Xiao","familyName":"Chen","affiliation":[],"nameIdentifiers":[]},{"name":"Uttarotai, Grace J.","nameType":"Personal","givenName":"Grace J.","familyName":"Uttarotai","affiliation":[],"nameIdentifiers":[]},{"name":"Callihan, Evan C.","nameType":"Personal","givenName":"Evan C.","familyName":"Callihan","affiliation":[],"nameIdentifiers":[]},{"name":"McCloud, Sierra S.","nameType":"Personal","givenName":"Sierra S.","familyName":"McCloud","affiliation":[],"nameIdentifiers":[]},{"name":"Clay, Derek M.","nameType":"Personal","givenName":"Derek M.","familyName":"Clay","affiliation":[],"nameIdentifiers":[]},{"name":"Jingmei Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Nowacki, Mariusz","nameType":"Personal","givenName":"Mariusz","familyName":"Nowacki","affiliation":[],"nameIdentifiers":[]},{"name":"Landweber, Laura F.","nameType":"Personal","givenName":"Laura F.","familyName":"Landweber","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Chromosome fusions triggered by noncoding RNA"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2016,"subjects":[{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"Cancer"},{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2016-06-07","dateType":"Created"},{"date":"2017-05-25","dateType":"Updated"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/15476286.2016.1195940","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["11982136 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Chromosomal fusions are common in normal and cancer cells and can produce aberrant gene products that promote transformation. The mechanisms driving these fusions are poorly understood, but recurrent fusions are widespread. This suggests an underlying mechanism, and some authors have proposed a possible role for RNA in this process. The unicellular eukaryote \u003ci\u003eOxytricha trifallax\u003c/i\u003e displays an exorbitant capacity for natural genome editing, when it rewrites its germline genome to form a somatic epigenome. This developmental process provides a powerful model system to directly test the influence of small noncoding RNAs on chromosome fusion events during somatic differentiation. Here we show that small RNAs are capable of inducing chromosome fusions in 4 distinct cases (out of 4 tested), including one fusion of 3 chromosomes. We further show that these RNA-mediated chromosome fusions are heritable over multiple sexual generations and that transmission of the acquired fusion is associated with endogenous production of novel piRNA molecules that target the fused junction. We also demonstrate the capacity of a long noncoding RNA (lncRNA) to induce chromosome fusion of 2 distal germline loci. These results underscore the ability of short-lived, aberrant RNAs to act as drivers of chromosome fusion events that can be stably transmitted to future generations.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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