{"data":{"id":"10.6084/m9.figshare.3409939.v2","type":"dois","attributes":{"doi":"10.6084/m9.figshare.3409939.v2","prefix":"10.6084","suffix":"m9.figshare.3409939.v2","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"El-Hashash, Maher A.","nameType":"Personal","givenName":"Maher A.","familyName":"El-Hashash","affiliation":[],"nameIdentifiers":[]},{"name":"El-Naggar, Abeer M.","nameType":"Personal","givenName":"Abeer M.","familyName":"El-Naggar","affiliation":[],"nameIdentifiers":[]},{"name":"El-Bordany, Eman A.","nameType":"Personal","givenName":"Eman A.","familyName":"El-Bordany","affiliation":[],"nameIdentifiers":[]},{"name":"Marzouk, Magda I.","nameType":"Personal","givenName":"Magda I.","familyName":"Marzouk","affiliation":[],"nameIdentifiers":[]},{"name":"Nawar, Tarek M. S.","nameType":"Personal","givenName":"Tarek M. S.","familyName":"Nawar","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Regioselectivity and regiospecificity of benzoxazinone (2-isopropyl-4\u003ci\u003eH\u003c/i\u003e-3,1-benzoxazinone) derivatives toward nitrogen nucleophiles and evaluation of antimicrobial activity"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2016,"subjects":[{"subject":"Biochemistry"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Medicine"},{"subject":"Pharmacology"},{"subject":"Biotechnology"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"69999 Biological Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Plant Biology"},{"subject":"60506 Virology","subjectScheme":"FOR"}],"contributors":[],"dates":[{"date":"2016-07-13","dateType":"Created"},{"date":"2016-07-27","dateType":"Updated"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/00397911.2016.1194998","relatedIdentifierType":"DOI"},{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.3409939","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["9717487 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"A novel group of 6-iodoquinazolin-4(\u003ci\u003e3H\u003c/i\u003e)-one derivatives was prepared. The reaction of the benzoxazinone \u003cb\u003e3\u003c/b\u003e with various nitrogen nucleophiles such as formamide and hydrazine hydrate and also the reaction of the isopropylquinazolinone \u003cb\u003e4\u003c/b\u003e with hydrazonyl chloride have been shown to proceed with a high degree of regioselectivity at C(2). Spiro heterocycles have been found to play fundamental roles in biological processes and have exhibited diversified biological activity and pharmacological and therapeutical properties; thus reaction of acetohydrazides \u003cb\u003e10a–c\u003c/b\u003e afforded the spiro compounds \u003cb\u003e11a–c\u003c/b\u003e. The acetohydrazide derivative \u003cb\u003e7\u003c/b\u003e reacted with carbon electrophiles such as acetylacetone, ethyl acetoacetate, acid chlorides, and benzaldehyde to give some interesting heterocyclic compounds \u003cb\u003e12–16\u003c/b\u003e, respectively. The structures of all the synthesized compounds were inferred by infrared, \u003csup\u003e1\u003c/sup\u003eH NMR, and mass spectra as well as elemental analyses. The antimicrobial activities of some of the synthesized products were preliminarily evaluated.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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