{"data":{"id":"10.6084/m9.figshare.3259915.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.3259915.v1","prefix":"10.6084","suffix":"m9.figshare.3259915.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Hohmann, Tim","nameType":"Personal","givenName":"Tim","familyName":"Hohmann","affiliation":[],"nameIdentifiers":[]},{"name":"Grabiec, Urszula","nameType":"Personal","givenName":"Urszula","familyName":"Grabiec","affiliation":[],"nameIdentifiers":[]},{"name":"Chalid Ghadban","affiliation":[],"nameIdentifiers":[]},{"name":"Feese, Kerstin","nameType":"Personal","givenName":"Kerstin","familyName":"Feese","affiliation":[],"nameIdentifiers":[]},{"name":"Dehghani, Faramarz","nameType":"Personal","givenName":"Faramarz","familyName":"Dehghani","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"The Influence of Biomechanical Properties and Cannabinoids on Tumor Invasion"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2016,"subjects":[{"subject":"Biophysics"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"Biotechnology"},{"subject":"19999 Mathematical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Mathematics","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Mathematics","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Developmental Biology"},{"subject":"Cancer"}],"contributors":[],"dates":[{"date":"2016-05-05","dateType":"Created"},{"date":"2016-05-05","dateType":"Updated"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/19336918.2016.1183867","relatedIdentifierType":"DOI"},{"relationType":"IsPreviousVersionOf","relatedIdentifier":"10.6084/m9.figshare.3259915","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["27250942 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"\u003cb\u003eBackground\u003c/b\u003e: Cannabinoids are known to have an anti-tumorous effect, but the underlying mechanisms are only sparsely understood. Mechanical characteristics of tumor cells represent a promising marker to distinguish between tumor cells and the healthy tissue. We tested the hypothesis whether cannabinoids influence the tumor cell specific mechanical and migratory properties and if these factors are a prognostic marker for the invasiveness of tumor cells. \u003cb\u003eMethods\u003c/b\u003e: 3 different glioblastoma cell lines were treated with cannabinoids and changes of mechanical and migratory properties of single cells were measured using atomic force microscopy and time lapse imaging. The invasiveness of cell lines was determined using a co-culture model with organotypic hippocampal slice cultures. \u003cb\u003eResults\u003c/b\u003e: We found that cannabinoids are capable of influencing migratory and mechanical properties in a cell line specific manner. A network analysis revealed a correlation between a “generalized stiffness” and the invasiveness for all tumor cell lines after 3 and 4 days of invasion time: \u003ci\u003er\u003c/i\u003e\u003csub\u003e\u003ci\u003e3d\u003c/i\u003e\u003c/sub\u003e =−\u003ci\u003e0.88\u003c/i\u003e [−0.52;−0.97]; r\u003csub\u003e\u003ci\u003e4d\u003c/i\u003e\u003c/sub\u003e =−\u003ci\u003e0.90\u003c/i\u003e [−0.59;−0.98]. \u003cb\u003eConclusions\u003c/b\u003e: Here we could show that a “generalized stiffness” is a profound marker for the invasiveness of a tumor cell population in our model and thus might be of high clinical relevance for drug testing. Additionally cannabinoids were shown to be of potential use for therapeutic approaches of glioblastoma.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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