{"data":{"id":"10.6084/m9.figshare.3188869.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.3188869.v1","prefix":"10.6084","suffix":"m9.figshare.3188869.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Okubo, Shingo","nameType":"Personal","givenName":"Shingo","familyName":"Okubo","affiliation":[],"nameIdentifiers":[]},{"name":"Miyamoto, Makoto","nameType":"Personal","givenName":"Makoto","familyName":"Miyamoto","affiliation":[],"nameIdentifiers":[]},{"name":"Ito, Dai","nameType":"Personal","givenName":"Dai","familyName":"Ito","affiliation":[],"nameIdentifiers":[]},{"name":"Takami, Kenji","nameType":"Personal","givenName":"Kenji","familyName":"Takami","affiliation":[],"nameIdentifiers":[]},{"name":"Ashida, Kiyoshi","nameType":"Personal","givenName":"Kiyoshi","familyName":"Ashida","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Albumin and apolipoprotein H mRNAs in human plasma as potential clinical biomarkers of liver injury: analyses of plasma liver-specific mRNAs in patients with liver injury"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2016,"subjects":[{"subject":"Biochemistry"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Medicine"},{"subject":"Microbiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Molecular Biology"},{"subject":"Biotechnology"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"60506 Virology","subjectScheme":"FOR"}],"contributors":[],"dates":[{"date":"2016-04-22","dateType":"Created"},{"date":"2016-04-22","dateType":"Updated"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.3109/1354750x.2016.1141987","relatedIdentifierType":"DOI"},{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.3188869","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["879647 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"\u003ci\u003eContext\u003c/i\u003e: Plasma liver-specific mRNAs are useful biomarkers of hepatotoxicity in rats. \u003ci\u003eObjective\u003c/i\u003e: To investigate the potential application of liver-specific mRNAs as biomarkers for liver injury in humans. \u003ci\u003eMethods\u003c/i\u003e: We determined the plasma levels of liver-specific mRNAs by real-time qRT-PCR in healthy donors and patients with liver injury. \u003ci\u003eResults\u003c/i\u003e: Plasma levels of albumin (ALB) and apolipoprotein H (APOH) mRNAs increased in patients with elevated serum alanine aminotransferase. These mRNAs also increased in plasma after transcatheter arterial chemoembolization, which induces specific injury to liver. \u003ci\u003eConclusions\u003c/i\u003e: We demonstrated the potential application of plasma ALB and APOH mRNAs as clinical biomarkers for liver injury.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"PD94bWwgdmVyc2lvbj0iMS4wIiBlbmNvZGluZz0iVVRGLTgiPz4KPHJlc291cmNlIHhtbG5zPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCIgeG1sbnM6eHNpPSJodHRwOi8vd3d3LnczLm9yZy8yMDAxL1hNTFNjaGVtYS1pbnN0YW5jZSIgeHNpOnNjaGVtYUxvY2F0aW9uPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCBodHRwOi8vc2NoZW1hLmRhdGFjaXRlLm9yZy9tZXRhL2tlcm5lbC00LjEvbWV0YWRhdGEueHNkIj4KICA8aWRlbnRpZmllciBpZGVudGlmaWVyVHlwZT0iRE9JIj4xMC42MDg0L005LkZJR1NIQVJFLjMxODg4NjkuVjE8L2lkZW50aWZpZXI+CiAgPGNyZWF0b3JzPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5TaGluZ28gT2t1Ym88L2NyZWF0b3JOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5NYWtvdG8gTWl5YW1vdG88L2NyZWF0b3JOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5EYWkgSXRvPC9jcmVhdG9yTmFtZT4KICAgIDwvY3JlYXRvcj4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+S2VuamkgVGFrYW1pPC9jcmVhdG9yTmFtZT4KICAgIDwvY3JlYXRvcj4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+S2l5b3NoaSBBc2hpZGE8L2NyZWF0b3JOYW1lPgogICAgPC9jcmVhdG9yPgogIDwvY3JlYXRvcnM+CiAgPHRpdGxlcz4KICAgIDx0aXRsZT5BbGJ1bWluIGFuZCBhcG9saXBvcHJvdGVpbiBIIG1STkFzIGluIGh1bWFuIHBsYXNtYSBhcyBwb3RlbnRpYWwgY2xpbmljYWwgYmlvbWFya2VycyBvZiBsaXZlciBpbmp1cnk6IGFuYWx5c2VzIG9mIHBsYXNtYSBsaXZlci1zcGVjaWZpYyBtUk5BcyBpbiBwYXRpZW50cyB3aXRoIGxpdmVyIGluanVyeTwvdGl0bGU+CiAgPC90aXRsZXM+CiAgPGRlc2NyaXB0aW9ucz4KICAgIDxkZXNjcmlwdGlvbiBkZXNjcmlwdGlvblR5cGU9IkFic3RyYWN0Ij4mbHQ7cCZndDsmbHQ7aSZndDtDb250ZXh0Jmx0Oy9pJmd0OzogUGxhc21hIGxpdmVyLXNwZWNpZmljIG1STkFzIGFyZSB1c2VmdWwgYmlvbWFya2VycyBvZiBoZXBhdG90b3hpY2l0eSBpbiByYXRzLiZsdDsvcCZndDsgJmx0O3AmZ3Q7Jmx0O2kmZ3Q7T2JqZWN0aXZlJmx0Oy9pJmd0OzogVG8gaW52ZXN0aWdhdGUgdGhlIHBvdGVudGlhbCBhcHBsaWNhdGlvbiBvZiBsaXZlci1zcGVjaWZpYyBtUk5BcyBhcyBiaW9tYXJrZXJzIGZvciBsaXZlciBpbmp1cnkgaW4gaHVtYW5zLiZsdDsvcCZndDsgJmx0O3AmZ3Q7Jmx0O2kmZ3Q7TWV0aG9kcyZsdDsvaSZndDs6IFdlIGRldGVybWluZWQgdGhlIHBsYXNtYSBsZXZlbHMgb2YgbGl2ZXItc3BlY2lmaWMgbVJOQXMgYnkgcmVhbC10aW1lIHFSVC1QQ1IgaW4gaGVhbHRoeSBkb25vcnMgYW5kIHBhdGllbnRzIHdpdGggbGl2ZXIgaW5qdXJ5LiZsdDsvcCZndDsgJmx0O3AmZ3Q7Jmx0O2kmZ3Q7UmVzdWx0cyZsdDsvaSZndDs6IFBsYXNtYSBsZXZlbHMgb2YgYWxidW1pbiAoQUxCKSBhbmQgYXBvbGlwb3Byb3RlaW4gSCAoQVBPSCkgbVJOQXMgaW5jcmVhc2VkIGluIHBhdGllbnRzIHdpdGggZWxldmF0ZWQgc2VydW0gYWxhbmluZSBhbWlub3RyYW5zZmVyYXNlLiBUaGVzZSBtUk5BcyBhbHNvIGluY3JlYXNlZCBpbiBwbGFzbWEgYWZ0ZXIgdHJhbnNjYXRoZXRlciBhcnRlcmlhbCBjaGVtb2VtYm9saXphdGlvbiwgd2hpY2ggaW5kdWNlcyBzcGVjaWZpYyBpbmp1cnkgdG8gbGl2ZXIuJmx0Oy9wJmd0OyAmbHQ7cCZndDsmbHQ7aSZndDtDb25jbHVzaW9ucyZsdDsvaSZndDs6IFdlIGRlbW9uc3RyYXRlZCB0aGUgcG90ZW50aWFsIGFwcGxpY2F0aW9uIG9mIHBsYXNtYSBBTEIgYW5kIEFQT0ggbVJOQXMgYXMgY2xpbmljYWwgYmlvbWFya2VycyBmb3IgbGl2ZXIgaW5qdXJ5LiZsdDsvcCZndDs8L2Rlc2NyaXB0aW9uPgogIDwvZGVzY3JpcHRpb25zPgogIDxzdWJqZWN0cz4KICAgIDxzdWJqZWN0PkJpb2NoZW1pc3RyeTwvc3ViamVjdD4KICAgIDxzdWJqZWN0IHNjaGVtZVVSST0iaHR0cDovL3d3dy5hYnMuZ292LmF1L2F1c3N0YXRzL2Fic0AubnNmLzAvNkJCNDI3QUI5Njk2QzIyNUNBMjU3NDE4MDAwNDQ2M0UiIHN1YmplY3RTY2hlbWU9IkZPUiI+Mjk5OTkgUGh5c2ljYWwgU2NpZW5jZXMgbm90IGVsc2V3aGVyZSBjbGFzc2lmaWVkPC9zdWJqZWN0PgogICAgPHN1YmplY3Q+TWVkaWNpbmU8L3N1YmplY3Q+CiAgICA8c3ViamVjdD5NaWNyb2Jpb2xvZ3k8L3N1YmplY3Q+CiAgICA8c3ViamVjdD5DZWxsIEJpb2xvZ3k8L3N1YmplY3Q+CiAgICA8c3ViamVjdD5Nb2xlY3VsYXIgQmlvbG9neTwvc3ViamVjdD4KICAgIDxzdWJqZWN0PkJpb3RlY2hub2xvZ3k8L3N1YmplY3Q+CiAgICA8c3ViamVjdCBzY2hlbWVVUkk9Imh0dHA6Ly93d3cuYWJzLmdvdi5hdS9hdXNzdGF0cy9hYnNALm5zZi8wLzZCQjQyN0FCOTY5NkMyMjVDQTI1NzQxODAwMDQ0NjNFIiBzdWJqZWN0U2NoZW1lPSJGT1IiPjM5OTk5IENoZW1pY2FsIFNjaWVuY2VzIG5vdCBlbHNld2hlcmUgY2xhc3NpZmllZDwvc3ViamVjdD4KICAgIDxzdWJqZWN0PkltbXVub2xvZ3k8L3N1YmplY3Q+CiAgICA8c3ViamVjdCBzY2hlbWVVUkk9Imh0dHA6Ly93d3cuYWJzLmdvdi5hdS9hdXNzdGF0cy9hYnNALm5zZi8wLzZCQjQyN0FCOTY5NkMyMjVDQTI1NzQxODAwMDQ0NjNFIiBzdWJqZWN0U2NoZW1lPSJGT1IiPjYwNTA2IFZpcm9sb2d5PC9zdWJqZWN0PgogIDwvc3ViamVjdHM+CiAgPHB1Ymxpc2hlcj5UYXlsb3IgJmFtcDsgRnJhbmNpczwvcHVibGlzaGVyPgogIDxwdWJsaWNhdGlvblllYXI+MjAxNjwvcHVibGljYXRpb25ZZWFyPgogIDxkYXRlcz4KICAgIDxkYXRlIGRhdGVUeXBlPSJDcmVhdGVkIj4yMDE2LTA0LTIyPC9kYXRlPgogICAgPGRhdGUgZGF0ZVR5cGU9IlVwZGF0ZWQiPjIwMTYtMDQtMjI8L2RhdGU+CiAgPC9kYXRlcz4KICA8cmVzb3VyY2VUeXBlIHJlc291cmNlVHlwZUdlbmVyYWw9IkRhdGFzZXQiPkRhdGFzZXQ8L3Jlc291cmNlVHlwZT4KICA8c2l6ZXM+CiAgICA8c2l6ZT44Nzk2NDcgQnl0ZXM8L3NpemU+CiAgPC9zaXplcz4KICA8cmVsYXRlZElkZW50aWZpZXJzPgogICAgPHJlbGF0ZWRJZGVudGlmaWVyIHJlbGF0ZWRJZGVudGlmaWVyVHlwZT0iRE9JIiByZWxhdGlvblR5cGU9IklzU3VwcGxlbWVudFRvIj4xMC4zMTA5LzEzNTQ3NTBYLjIwMTYuMTE0MTk4NzwvcmVsYXRlZElkZW50aWZpZXI+CiAgICA8cmVsYXRlZElkZW50aWZpZXIgcmVsYXRlZElkZW50aWZpZXJUeXBlPSJET0kiIHJlbGF0aW9uVHlwZT0iSXNJZGVudGljYWxUbyI+MTAuNjA4NC9tOS5maWdzaGFyZS4zMTg4ODY5PC9yZWxhdGVkSWRlbnRpZmllcj4KICA8L3JlbGF0ZWRJZGVudGlmaWVycz4KICA8cmlnaHRzTGlzdD4KICAgIDxyaWdodHMgcmlnaHRzVVJJPSJodHRwczovL2NyZWF0aXZlY29tbW9ucy5vcmcvbGljZW5zZXMvYnkvNC4wLyI+Q0MgQlkgNC4wPC9yaWdodHM+CiAgPC9yaWdodHNMaXN0Pgo8L3Jlc291cmNlPg==","url":"https://tandf.figshare.com/articles/dataset/Albumin_and_apolipoprotein_H_mRNAs_in_human_plasma_as_potential_clinical_biomarkers_of_liver_injury_analyses_of_plasma_liver_specific_mRNAs_in_patients_with_liver_injury/31888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