{"data":{"id":"10.6084/m9.figshare.3153160.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.3153160.v1","prefix":"10.6084","suffix":"m9.figshare.3153160.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Hridya Hemachandran","affiliation":[],"nameIdentifiers":[]},{"name":"Anantharaman, Amrita","nameType":"Personal","givenName":"Amrita","familyName":"Anantharaman","affiliation":[],"nameIdentifiers":[]},{"name":"Priya, Rajendra Rao","nameType":"Personal","givenName":"Rajendra Rao","familyName":"Priya","affiliation":[],"nameIdentifiers":[]},{"name":"Doss, George Priya","nameType":"Personal","givenName":"George Priya","familyName":"Doss","affiliation":[],"nameIdentifiers":[]},{"name":"Ramamoorthy Siva","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Interaction of Catechu Dye with DNA: Spectroscopic and In Silico Approach"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2016,"subjects":[{"subject":"Biophysics"},{"subject":"Biochemistry"},{"subject":"Space Science"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Medicine"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"Pharmacology"},{"subject":"Biotechnology"},{"subject":"59999 Environmental Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Earth and related environmental sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Earth and related environmental sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"69999 Biological Sciences not elsewhere classified","subjectScheme":"FOR"}],"contributors":[],"dates":[{"date":"2016-04-04","dateType":"Created"},{"date":"2016-04-04","dateType":"Updated"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/15257770.2015.1124997","relatedIdentifierType":"DOI"},{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.3153160","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["285584 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Catechin, a yellow colored molecule obtained from the wood of Acacia catechu was analyzed for its interaction with synthetic DNA duplexes using spectroscopic analysis. UV-Visible spectroscopic analysis revealed the non-intercalative binding mode. Fourier Transform Infrared spectroscopy (FTIR) analysis expose chemical shift indicated by various vibrational stretches and an increase in the intensity of base stacking was observed by Circular Dichroism (CD), respectively. This inference was further confirmed through nuclear staining technique and also in electrophoretic technique; the dye quenches the fluorescent intensity of ethidium bromide. The result of fluorescence spectroscopy was in concordance with the electrophoretic technique. In addition, the spectroscopic results were in accordance with the molecular docking studies of specific catechin compound from the catechu dye with CT-DNA. This kind of site specificity is a gain in the medicinal field as the drug can be DNA targeted for cancer therapeutics. The present work reveals that catechu dye has a noteworthy application in the field of medical bioscience.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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