{"data":{"id":"10.6084/m9.figshare.3116704","type":"dois","attributes":{"doi":"10.6084/m9.figshare.3116704","prefix":"10.6084","suffix":"m9.figshare.3116704","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Hina Saini","affiliation":[],"nameIdentifiers":[]},{"name":"Chhibber, Sanjay","nameType":"Personal","givenName":"Sanjay","familyName":"Chhibber","affiliation":[],"nameIdentifiers":[]},{"name":"Harjai, Kusum","nameType":"Personal","givenName":"Kusum","familyName":"Harjai","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Antimicrobial and antifouling efficacy of urinary catheters impregnated with a combination of macrolide and fluoroquinolone antibiotics against \u003ci\u003ePseudomonas aeruginosa\u003c/i\u003e"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2016,"subjects":[{"subject":"Medicine"},{"subject":"Pharmacology"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"20199 Astronomical and Space Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"69999 Biological Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cancer"},{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"60506 Virology","subjectScheme":"FOR"}],"contributors":[],"dates":[{"date":"2016-03-16","dateType":"Created"},{"date":"2016-04-26","dateType":"Updated"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/08927014.2016.1155564","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["9989563 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"The incidence of catheter associated urinary tract infections (CAUTIs) is increasing worldwide. This study was designed to modify a biomaterial by impregnating a silicone urinary catheter with combination of a macrolide, azithromycin (AZM) and a fluoroquinolone, ciprofloxacin (CIP). Drug release profiles showed slow yet continuous release of antibiotics from catheters for one month. \u003ci\u003eIn vitro\u003c/i\u003e efficacy testing showed that group B catheters [3% (w v\u003csup\u003e−1\u003c/sup\u003e) CIP + 6% (w v\u003csup\u003e−1\u003c/sup\u003e) AZM] outperformed group A catheters [2% (w v\u003csup\u003e−1\u003c/sup\u003e) CIP + 5% (w v\u003csup\u003e−1\u003c/sup\u003e) AZM] by (1) showing larger zones of inhibition (\u0026gt;31 mm) compared to group A (\u0026lt;28 mm) for up to 30 days against \u003ci\u003ePseudomonas aeruginosa\u003c/i\u003e PAO1; (2) killing adhered bacteria in 24 h compared to 24–48 h in group A; (3) showing longer antimicrobial durability for four weeks; and (4) exhibiting a stable real-time shelf life of one year, suggesting that these catheters can be explored in clinical settings, especially in long-term CAUTI.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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