{"data":{"id":"10.6084/m9.figshare.3115600","type":"dois","attributes":{"doi":"10.6084/m9.figshare.3115600","prefix":"10.6084","suffix":"m9.figshare.3115600","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Okimura, Chika","nameType":"Personal","givenName":"Chika","familyName":"Okimura","affiliation":[],"nameIdentifiers":[]},{"name":"Ueda, Kazuki","nameType":"Personal","givenName":"Kazuki","familyName":"Ueda","affiliation":[],"nameIdentifiers":[]},{"name":"Sakumura, Yuichi","nameType":"Personal","givenName":"Yuichi","familyName":"Sakumura","affiliation":[],"nameIdentifiers":[]},{"name":"Iwadate, Yoshiaki","nameType":"Personal","givenName":"Yoshiaki","familyName":"Iwadate","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Fast-crawling cell types migrate to avoid the direction of periodic substratum stretching"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2016,"subjects":[{"subject":"Biophysics"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Medicine"},{"subject":"Cell Biology"},{"subject":"Molecular Biology"},{"subject":"Sociology"},{"subject":"FOS: Sociology","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Sociology","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"59999 Environmental Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Earth and related environmental sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Earth and related environmental sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"69999 Biological Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Developmental Biology"}],"contributors":[],"dates":[{"date":"2016-03-16","dateType":"Created"},{"date":"2017-12-14","dateType":"Updated"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/19336918.2015.1129482","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["2064305 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"To investigate the relationship between mechanical stimuli from substrata and related cell functions, one of the most useful techniques is the application of mechanical stimuli via periodic stretching of elastic substrata. In response to this stimulus, \u003ci\u003eDictyostelium discoideum\u003c/i\u003e cells migrate in a direction perpendicular to the stretching direction. The origins of directional migration, higher migration velocity in the direction perpendicular to the stretching direction or the higher probability of a switch of migration direction to perpendicular to the stretching direction, however, remain unknown. In this study, we applied periodic stretching stimuli to neutrophil-like differentiated HL-60 cells, which migrate perpendicular to the direction of stretch. Detailed analysis of the trajectories of HL-60 cells and \u003ci\u003eDictyostelium\u003c/i\u003e cells obtained in a previous study revealed that the higher probability of a switch of migration direction to that perpendicular to the direction of stretching was the main cause of such directional migration. This directional migration appears to be a strategy adopted by fast-crawling cells in which they do not migrate faster in the direction they want to go, but migrate to avoid a direction they do not want to go.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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