{"data":{"id":"10.6084/m9.figshare.2074390.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.2074390.v1","prefix":"10.6084","suffix":"m9.figshare.2074390.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Xiao, Min","nameType":"Personal","givenName":"Min","familyName":"Xiao","affiliation":[],"nameIdentifiers":[]},{"name":"Li, Jin","nameType":"Personal","givenName":"Jin","familyName":"Li","affiliation":[],"nameIdentifiers":[]},{"name":"Li, Wei","nameType":"Personal","givenName":"Wei","familyName":"Li","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Yu","nameType":"Personal","givenName":"Yu","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Feizhen Wu","affiliation":[],"nameIdentifiers":[]},{"name":"Yanping Xi","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Lan","nameType":"Personal","givenName":"Lan","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Ding, Chao","nameType":"Personal","givenName":"Chao","familyName":"Ding","affiliation":[],"nameIdentifiers":[]},{"name":"Huaibing Luo","affiliation":[],"nameIdentifiers":[]},{"name":"Li, Yan","nameType":"Personal","givenName":"Yan","familyName":"Li","affiliation":[],"nameIdentifiers":[]},{"name":"Peng, Lina","nameType":"Personal","givenName":"Lina","familyName":"Peng","affiliation":[],"nameIdentifiers":[]},{"name":"Liping Zhao","affiliation":[],"nameIdentifiers":[]},{"name":"Shaoliang Peng","affiliation":[],"nameIdentifiers":[]},{"name":"Xiao, Yao","nameType":"Personal","givenName":"Yao","familyName":"Xiao","affiliation":[],"nameIdentifiers":[]},{"name":"Shihua Dong","affiliation":[],"nameIdentifiers":[]},{"name":"Cao, Jie","nameType":"Personal","givenName":"Jie","familyName":"Cao","affiliation":[],"nameIdentifiers":[]},{"name":"Wenqiang Yu","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"MicroRNAs Activate Gene Transcription Epigenetically as an Enhancer Trigger"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2016,"subjects":[{"subject":"Biophysics"},{"subject":"Biochemistry"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"Neuroscience"},{"subject":"Developmental Biology"},{"subject":"Cancer"},{"subject":"111714 Mental Health","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"}],"contributors":[],"dates":[{"date":"2016-02-06","dateType":"Created"},{"date":"2020-08-24","dateType":"Updated"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/15476286.2015.1112487","relatedIdentifierType":"DOI"},{"relationType":"IsPreviousVersionOf","relatedIdentifier":"10.6084/m9.figshare.2074390","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["40325633 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"MicroRNAs (miRNAs) are small non-coding RNAs that function as negative gene expression regulators. Emerging evidence shows that, except for function in the cytoplasm, miRNAs are also present in the nucleus. However, the functional significance of nuclear miRNAs remains largely undetermined. By screening miRNA database, we have identified a subset of miRNA that function as enhancer regulator. Here, we found a set of miRNAs show gene-activation function. We focused on miR-24-1 and found that this miRNA unconventionally activates gene transcription by targeting enhancers. Consistently, the activation was completely abolished when the enhancer sequence was deleted by TALEN. Furthermore, we found that miR-24-1 activates enhancer RNA (eRNA) expression, alters histone modification, and increases the enrichment of p300 and RNA Pol II at the enhancer locus. Our results demonstrate a novel mechanism of miRNA as an enhancer 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