{"data":{"id":"10.6084/m9.figshare.19488383.v3","type":"dois","attributes":{"doi":"10.6084/m9.figshare.19488383.v3","prefix":"10.6084","suffix":"m9.figshare.19488383.v3","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Cassa, Christopher","givenName":"Christopher","familyName":"Cassa","affiliation":[],"nameIdentifiers":[]},{"name":"Sunyaev, Shamil R.","givenName":"Shamil R.","familyName":"Sunyaev","affiliation":[],"nameIdentifiers":[]},{"name":"Lee, Daniel","givenName":"Daniel","familyName":"Lee","affiliation":[],"nameIdentifiers":[]},{"name":"Seplyarskiy, Vladimir","givenName":"Vladimir","familyName":"Seplyarskiy","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Estimates of heterozygous selection per gene, derived from gnomAD v2.1.1"}],"publisher":"figshare","container":{},"publicationYear":2022,"subjects":[{"subject":"110311 Medical Genetics (excl. Cancer Genetics)","schemeUri":"http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E","subjectScheme":"FOR"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"60412 Quantitative Genetics (incl. Disease and Trait Mapping Genetics)","schemeUri":"http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E","subjectScheme":"FOR"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"60411 Population, Ecological and Evolutionary Genetics","schemeUri":"http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E","subjectScheme":"FOR"},{"subject":"Genetics"}],"contributors":[],"dates":[{"date":"2022-04-12","dateType":"Created"},{"date":"2022-04-12","dateType":"Updated"},{"date":"2022","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.19488383","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["1371898 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"We update the mean of the posterior distribution using 125,748 exomes from gnomAD v2.1.1 and with an updated mutational model, Roulette. We also perform a stringent cutoff of allele frequency of 0.01%, to improve sensitivity to autosomal dominant disease genes under strong selection.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"PD94bWwgdmVyc2lvbj0iMS4wIiBlbmNvZGluZz0iVVRGLTgiPz4KPHJlc291cmNlIHhtbG5zPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCIgeG1sbnM6eHNpPSJodHRwOi8vd3d3LnczLm9yZy8yMDAxL1hNTFNjaGVtYS1pbnN0YW5jZSIgeHNpOnNjaGVtYUxvY2F0aW9uPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCBodHRwOi8vc2NoZW1hLmRhdGFjaXRlLm9yZy9tZXRhL2tlcm5lbC00LjQvbWV0YWRhdGEueHNkIj4KICA8aWRlbnRpZmllciBpZGVudGlmaWVyVHlwZT0iRE9JIj4xMC42MDg0L005LkZJR1NIQVJFLjE5NDg4MzgzLlYzPC9pZGVudGlmaWVyPgogIDxjcmVhdG9ycz4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+Q2hyaXN0b3BoZXIgQ2Fzc2E8L2NyZWF0b3JOYW1lPgogICAgICA8Z2l2ZW5OYW1lPkNocmlzdG9waGVyPC9naXZlbk5hbWU+CiAgICAgIDxmYW1pbHlOYW1lPkNhc3NhPC9mYW1pbHlOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5TaGFtaWwgUi4gU3VueWFldjwvY3JlYXRvck5hbWU+CiAgICAgIDxnaXZlbk5hbWU+U2hhbWlsIFIuPC9naXZlbk5hbWU+CiAgICAgIDxmYW1pbHlOYW1lPlN1bnlhZXY8L2ZhbWlseU5hbWU+CiAgICA8L2NyZWF0b3I+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPkRhbmllbCBMZWU8L2NyZWF0b3JOYW1lPgogICAgICA8Z2l2ZW5OYW1lPkRhbmllbDwvZ2l2ZW5OYW1lPgogICAgICA8ZmFtaWx5TmFtZT5MZWU8L2ZhbWlseU5hbWU+CiAgICA8L2NyZWF0b3I+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPlZsYWRpbWlyIFNlcGx5YXJza2l5PC9jcmVhdG9yTmFtZT4KICAgICAgPGdpdmVuTmFtZT5WbGFkaW1pcjwvZ2l2ZW5OYW1lPgogICAgICA8ZmFtaWx5TmFtZT5TZXBseWFyc2tpeTwvZmFtaWx5TmFtZT4KICAgIDwvY3JlYXRvcj4KICA8L2NyZWF0b3JzPgogIDx0aXRsZXM+CiAgICA8dGl0bGU+RXN0aW1hdGVzIG9mIGhldGVyb3p5Z291cyBzZWxlY3Rpb24gcGVyIGdlbmUsIGRlcml2ZWQgZnJvbSBnbm9tQUQgdjIuMS4xPC90aXRsZT4KICA8L3RpdGxlcz4KICA8ZGVzY3JpcHRpb25zPgogICAgPGRlc2NyaXB0aW9uIGRlc2NyaXB0aW9uVHlwZT0iQWJzdHJhY3QiPldlIHVwZGF0ZSB0aGUgbWVhbiBvZiB0aGUgcG9zdGVyaW9yIGRpc3RyaWJ1dGlvbiB1c2luZyAxMjUsNzQ4IGV4b21lcyBmcm9tIGdub21BRCB2Mi4xLjEgYW5kIHdpdGggYW4gdXBkYXRlZCBtdXRhdGlvbmFsIG1vZGVsLCBSb3VsZXR0ZS4gV2UgYWxzbyBwZXJmb3JtIGEgc3RyaW5nZW50IGN1dG9mZiBvZiBhbGxlbGUgZnJlcXVlbmN5IG9mIDAuMDElLCB0byBpbXByb3ZlIHNlbnNpdGl2aXR5IHRvIGF1dG9zb21hbCBkb21pbmFudCBkaXNlYXNlIGdlbmVzIHVuZGVyIHN0cm9uZyBzZWxlY3Rpb24uPC9kZXNjcmlwdGlvbj4KICA8L2Rlc2NyaXB0aW9ucz4KICA8c3ViamVjdHM+CiAgICA8c3ViamVjdCBzY2hlbWVVUkk9Imh0dHA6Ly93d3cuYWJzLmdvdi5hdS9hdXNzdGF0cy9hYnNALm5zZi8wLzZCQjQyN0FCOTY5NkMyMjVDQTI1NzQxODAwMDQ0NjNFIiBzdWJqZWN0U2NoZW1lPSJGT1IiPjExMDMxMSBNZWRpY2FsIEdlbmV0aWNzIChleGNsLiBDYW5jZXIgR2VuZXRpY3MpPC9zdWJqZWN0PgogICAgPHN1YmplY3Qgc2NoZW1lVVJJPSJodHRwOi8vd3d3LmFicy5nb3YuYXUvYXVzc3RhdHMvYWJzQC5uc2YvMC82QkI0MjdBQjk2OTZDMjI1Q0EyNTc0MTgwMDA0NDYzRSIgc3ViamVjdFNjaGVtZT0iRk9SIj42MDQxMiBRdWFudGl0YXRpdmUgR2VuZXRpY3MgKGluY2wuIERpc2Vhc2UgYW5kIFRyYWl0IE1hcHBpbmcgR2VuZXRpY3MpPC9zdWJqZWN0PgogICAgPHN1YmplY3Qgc2NoZW1lVVJJPSJodHRwOi8vd3d3LmFicy5nb3YuYXUvYXVzc3RhdHMvYWJzQC5uc2YvMC82QkI0MjdBQjk2OTZDMjI1Q0EyNTc0MTgwMDA0NDYzRSIgc3ViamVjdFNjaGVtZT0iRk9SIj42MDQxMSBQb3B1bGF0aW9uLCBFY29sb2dpY2FsIGFuZCBFdm9sdXRpb25hcnkgR2VuZXRpY3M8L3N1YmplY3Q+CiAgICA8c3ViamVjdD5HZW5ldGljczwvc3ViamVjdD4KICA8L3N1YmplY3RzPgogIDxwdWJsaXNoZXI+Zmlnc2hhcmU8L3B1Ymxpc2hlcj4KICA8cHVibGljYXRpb25ZZWFyPjIwMjI8L3B1YmxpY2F0aW9uWWVhcj4KICA8ZGF0ZXM+CiAgICA8ZGF0ZSBkYXRlVHlwZT0iQ3JlYXRlZCI+MjAyMi0wNC0xMjwvZGF0ZT4KICAgIDxkYXRlIGRhdGVUeXBlPSJVcGRhdGVkIj4yMDIyLTA0LTEyPC9kYXRlPgogIDwvZGF0ZXM+CiAgPHJlc291cmNlVHlwZSByZXNvdXJjZVR5cGVHZW5lcmFsPSJEYXRhc2V0Ij5EYXRhc2V0PC9yZXNvdXJjZVR5cGU+CiAgPHNpemVzPgogICAgPHNpemU+MTM3MTg5OCBCeXRlczwvc2l6ZT4KICA8L3NpemVzPgogIDxyZWxhdGVkSWRlbnRpZmllcnM+CiAgICA8cmVsYXRlZElkZW50aWZpZXIgcmVsYXRlZElkZW50aWZpZXJUeXBlPSJET0kiIHJlbGF0aW9uVHlwZT0iSXNJZGVudGljYWxUbyI+MTAuNjA4NC9tOS5maWdzaGFyZS4xOTQ4ODM4MzwvcmVsYXRlZElkZW50aWZpZXI+CiAgPC9yZWxhdGVkSWRlbnRpZmllcnM+CiAgPHJpZ2h0c0xpc3Q+CiAgICA8cmlnaHRzIHJpZ2h0c1VSST0iaHR0cHM6Ly9jcmVhdGl2ZWNvbW1vbnMub3JnL2xpY2Vuc2VzL2J5LzQuMC8iPkNDIEJZIDQuMDwvcmlnaHRzPgogIDwvcmlnaHRzTGlzdD4KPC9yZXNvdXJjZT4=","url":"https://figshare.com/articles/dataset/Estimates_of_heterozygous_selection_per_gene_derived_from_gnomAD_v2_1_1/19488383/3","contentUrl":null,"metadataVersion":0,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":9,"viewsOverTime":[{"yearMonth":"2025-06","total":3},{"yearMonth":"2025-12","total":2},{"yearMonth":"2026-01","total":2},{"yearMonth":"2026-03","total":2}],"downloadCount":0,"downloadsOverTime":[{"yearMonth":"2025-06","total":0},{"yearMonth":"2025-12","total":0},{"yearMonth":"2026-01","total":0},{"yearMonth":"2026-03","total":0}],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2022-04-12T19:57:38.000Z","registered":"2022-04-12T19:57:39.000Z","published":"2022","updated":"2022-04-12T19:57:40.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.19488383.v3","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}