{"data":{"id":"10.6084/m9.figshare.16446954","type":"dois","attributes":{"doi":"10.6084/m9.figshare.16446954","prefix":"10.6084","suffix":"m9.figshare.16446954","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Vejražková, Daniela","givenName":"Daniela","familyName":"Vejražková","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Allele and haplotype frequencies of the Czech Graves´disease patients"}],"publisher":"figshare","container":{},"publicationYear":2021,"subjects":[{"subject":"110703 Autoimmunity","schemeUri":"http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E","subjectScheme":"FOR"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biomarkers"},{"subject":"110706 Immunogenetics (incl. Genetic Immunology)","schemeUri":"http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E","subjectScheme":"FOR"},{"subject":"110311 Medical Genetics (excl. Cancer Genetics)","schemeUri":"http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E","subjectScheme":"FOR"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2021-09-08","dateType":"Created"},{"date":"2021-09-08","dateType":"Updated"},{"date":"2021","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":["86016 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"We analyzed the HLA-\u003ci\u003eDRB1\u003c/i\u003e, HLA-\u003ci\u003eDQA1\u003c/i\u003e and HLA-\u003ci\u003eDQB1\u003c/i\u003e allelic groups in 206 retrospectively observed Czech patients who had been diagnosed with Graves' disease according to hormonal profile (low/suppressed TSH with simultaneously elevated freeT4, freeT3, presence of thyrotropin receptor antibodies (TRAK)) as well as sonographic examination of the thyroid gland. Patients were recruited during the years 2017-2020 mainly from the outpatients of the Institute of Endocrinology in Prague. These patients are continuously monitored at the Institute, which gives us detailed long-term or even lifelong retrospective information on the status of their disease. Next generation sequencing performed on a MiSeq (Illumina) was used for haplotyping. In the three HLA genes (\u003ci\u003eDRB1\u003c/i\u003e, \u003ci\u003eDQA1\u003c/i\u003e and \u003ci\u003eDQB1\u003c/i\u003e), exon 2 was amplified, since this part of the HLA molecule determines its antigenic properties. Amplification of DNA sequences was performed using certified kits (CE 0197, CE IVD) of allele-specific pre-coated PCR strips PROTRANS S4 HLA-DRB1 * (cat. No. 34 04), PROTRANS S3 HLA-DQB1 * (cat. No. 33 09) and PROTRANS S2 HLA-DQA1 * (cat. No. 32 08) from the manufacturer PentaGen, Protrans, Germany.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"PD94bWwgdmVyc2lvbj0iMS4wIiBlbmNvZGluZz0iVVRGLTgiPz4KPHJlc291cmNlIHhtbG5zPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCIgeG1sbnM6eHNpPSJodHRwOi8vd3d3LnczLm9yZy8yMDAxL1hNTFNjaGVtYS1pbnN0YW5jZSIgeHNpOnNjaGVtYUxvY2F0aW9uPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCBodHRwOi8vc2NoZW1hLmRhdGFjaXRlLm9yZy9tZXRhL2tlcm5lbC00LjEvbWV0YWRhdGEueHNkIj4KICA8aWRlbnRpZmllciBpZGVudGlmaWVyVHlwZT0iRE9JIj4xMC42MDg0L005LkZJR1NIQVJFLjE2NDQ2OTU0PC9pZGVudGlmaWVyPgogIDxjcmVhdG9ycz4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+RGFuaWVsYSBWZWpyYcW+a292w6E8L2NyZWF0b3JOYW1lPgogICAgICA8Z2l2ZW5OYW1lPkRhbmllbGE8L2dpdmVuTmFtZT4KICAgICAgPGZhbWlseU5hbWU+VmVqcmHFvmtvdsOhPC9mYW1pbHlOYW1lPgogICAgPC9jcmVhdG9yPgogIDwvY3JlYXRvcnM+CiAgPHRpdGxlcz4KICAgIDx0aXRsZT5BbGxlbGUgYW5kIGhhcGxvdHlwZSBmcmVxdWVuY2llcyBvZiB0aGUgQ3plY2ggR3JhdmVzwrRkaXNlYXNlIHBhdGllbnRzPC90aXRsZT4KICA8L3RpdGxlcz4KICA8ZGVzY3JpcHRpb25zPgogICAgPGRlc2NyaXB0aW9uIGRlc2NyaXB0aW9uVHlwZT0iQWJzdHJhY3QiPldlCmFuYWx5emVkIHRoZSBITEEtJmx0O2kmZ3Q7RFJCMSZsdDsvaSZndDssIEhMQS0mbHQ7aSZndDtEUUExJmx0Oy9pJmd0OyBhbmQgSExBLSZsdDtpJmd0O0RRQjEmbHQ7L2kmZ3Q7IGFsbGVsaWMgZ3JvdXBzIGluIDIwNgpyZXRyb3NwZWN0aXZlbHkgb2JzZXJ2ZWQgQ3plY2ggcGF0aWVudHMgd2hvIGhhZCBiZWVuIGRpYWdub3NlZCB3aXRoIEdyYXZlcycgZGlzZWFzZSBhY2NvcmRpbmcgdG8KaG9ybW9uYWwgcHJvZmlsZSAobG93L3N1cHByZXNzZWQgVFNICndpdGggc2ltdWx0YW5lb3VzbHkgZWxldmF0ZWQgZnJlZVQ0LCBmcmVlVDMsIHByZXNlbmNlIG9mIHRoeXJvdHJvcGluIHJlY2VwdG9yIGFudGlib2RpZXMgKFRSQUspKSBhcyB3ZWxsIGFzIHNvbm9ncmFwaGljIGV4YW1pbmF0aW9uIG9mIHRoZSB0aHlyb2lkIGdsYW5kLiBQYXRpZW50cyB3ZXJlIHJlY3J1aXRlZCBkdXJpbmcgdGhlIHllYXJzIDIwMTctMjAyMCBtYWlubHkgZnJvbSB0aGUKb3V0cGF0aWVudHMgb2YgdGhlIEluc3RpdHV0ZSBvZiBFbmRvY3Jpbm9sb2d5IGluIFByYWd1ZS4gVGhlc2UKcGF0aWVudHMgYXJlIGNvbnRpbnVvdXNseSBtb25pdG9yZWQgYXQKdGhlIEluc3RpdHV0ZSwgd2hpY2ggZ2l2ZXMgdXMgZGV0YWlsZWQgbG9uZy10ZXJtIG9yIGV2ZW4gbGlmZWxvbmcgcmV0cm9zcGVjdGl2ZQppbmZvcm1hdGlvbiBvbiB0aGUgc3RhdHVzIG9mIHRoZWlyIGRpc2Vhc2UuIE5leHQgZ2VuZXJhdGlvbgpzZXF1ZW5jaW5nIHBlcmZvcm1lZCBvbiBhIE1pU2VxIChJbGx1bWluYSkgd2FzIHVzZWQgZm9yIGhhcGxvdHlwaW5nLiBJbiB0aGUKdGhyZWUgSExBIGdlbmVzICgmbHQ7aSZndDtEUkIxJmx0Oy9pJmd0OywgJmx0O2kmZ3Q7RFFBMSZsdDsvaSZndDsgYW5kICZsdDtpJmd0O0RRQjEmbHQ7L2kmZ3Q7KSwgZXhvbiAyIHdhcyBhbXBsaWZpZWQsIHNpbmNlIHRoaXMgcGFydCBvZiB0aGUgSExBIG1vbGVjdWxlCmRldGVybWluZXMgaXRzIGFudGlnZW5pYyBwcm9wZXJ0aWVzLgpBbXBsaWZpY2F0aW9uIG9mIEROQSBzZXF1ZW5jZXMgd2FzIHBlcmZvcm1lZCB1c2luZyBjZXJ0aWZpZWQga2l0cyAoQ0UgMDE5NywgQ0UKSVZEKSBvZiBhbGxlbGUtc3BlY2lmaWMgcHJlLWNvYXRlZCBQQ1Igc3RyaXBzIFBST1RSQU5TIFM0IEhMQS1EUkIxICogKGNhdC4gTm8uCjM0IDA0KSwgUFJPVFJBTlMgUzMgSExBLURRQjEgKiAoY2F0LiBOby4gMzMgMDkpIGFuZCBQUk9UUkFOUyBTMiBITEEtRFFBMSAqCihjYXQuIE5vLiAzMiAwOCkgZnJvbSB0aGUgbWFudWZhY3R1cmVyIFBlbnRhR2VuLCBQcm90cmFucywgR2VybWFueS48L2Rlc2NyaXB0aW9uPgogIDwvZGVzY3JpcHRpb25zPgogIDxzdWJqZWN0cz4KICAgIDxzdWJqZWN0IHNjaGVtZVVSST0iaHR0cDovL3d3dy5hYnMuZ292LmF1L2F1c3N0YXRzL2Fic0AubnNmLzAvNkJCNDI3QUI5Njk2QzIyNUNBMjU3NDE4MDAwNDQ2M0UiIHN1YmplY3RTY2hlbWU9IkZPUiI+MTEwNzAzIEF1dG9pbW11bml0eTwvc3ViamVjdD4KICAgIDxzdWJqZWN0PkJpb21hcmtlcnM8L3N1YmplY3Q+CiAgICA8c3ViamVjdCBzY2hlbWVVUkk9Imh0dHA6Ly93d3cuYWJzLmdvdi5hdS9hdXNzdGF0cy9hYnNALm5zZi8wLzZCQjQyN0FCOTY5NkMyMjVDQTI1NzQxODAwMDQ0NjNFIiBzdWJqZWN0U2NoZW1lPSJGT1IiPjExMDcwNiBJbW11bm9nZW5ldGljcyAoaW5jbC4gR2VuZXRpYyBJbW11bm9sb2d5KTwvc3ViamVjdD4KICAgIDxzdWJqZWN0IHNjaGVtZVVSST0iaHR0cDovL3d3dy5hYnMuZ292LmF1L2F1c3N0YXRzL2Fic0AubnNmLzAvNkJCNDI3QUI5Njk2QzIyNUNBMjU3NDE4MDAwNDQ2M0UiIHN1YmplY3RTY2hlbWU9IkZPUiI+MTEwMzExIE1lZGljYWwgR2VuZXRpY3MgKGV4Y2wuIENhbmNlciBHZW5ldGljcyk8L3N1YmplY3Q+CiAgPC9zdWJqZWN0cz4KICA8cHVibGlzaGVyPmZpZ3NoYXJlPC9wdWJsaXNoZXI+CiAgPHB1YmxpY2F0aW9uWWVhcj4yMDIxPC9wdWJsaWNhdGlvblllYXI+CiAgPGRhdGVzPgogICAgPGRhdGUgZGF0ZVR5cGU9IkNyZWF0ZWQiPjIwMjEtMDktMDg8L2RhdGU+CiAgICA8ZGF0ZSBkYXRlVHlwZT0iVXBkYXRlZCI+MjAyMS0wOS0wODwvZGF0ZT4KICA8L2RhdGVzPgogIDxyZXNvdXJjZVR5cGUgcmVzb3VyY2VUeXBlR2VuZXJhbD0iRGF0YXNldCI+RGF0YXNldDwvcmVzb3VyY2VUeXBlPgogIDxzaXplcz4KICAgIDxzaXplPjg2MDE2IEJ5dGVzPC9zaXplPgogIDwvc2l6ZXM+CiAgPHJpZ2h0c0xpc3Q+CiAgICA8cmlnaHRzIHJpZ2h0c1VSST0iaHR0cHM6Ly9jcmVhdGl2ZWNvbW1vbnMub3JnL2xpY2Vuc2VzL2J5LzQuMC8iPkNDIEJZIDQuMDwvcmlnaHRzPgogIDwvcmlnaHRzTGlzdD4KPC9yZXNvdXJjZT4=","url":"https://figshare.com/articles/dataset/Allele_frequencies_of_Czech_GD_patients_xls/16446954","contentUrl":null,"metadataVersion":3,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2021-08-26T09:28:57.000Z","registered":"2021-08-26T09:28:57.000Z","published":"2021","updated":"2021-09-08T07:27:04.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.16446954","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":{"data":[]},"partO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