{"data":{"id":"10.6084/m9.figshare.1632864","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1632864","prefix":"10.6084","suffix":"m9.figshare.1632864","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Bissonnette, Laurence","nameType":"Personal","givenName":"Laurence","familyName":"Bissonnette","affiliation":[],"nameIdentifiers":[]},{"name":"Drissennek, Loubna","nameType":"Personal","givenName":"Loubna","familyName":"Drissennek","affiliation":[],"nameIdentifiers":[]},{"name":"Antoine, Yannick","nameType":"Personal","givenName":"Yannick","familyName":"Antoine","affiliation":[],"nameIdentifiers":[]},{"name":"Tiers, Laurent","nameType":"Personal","givenName":"Laurent","familyName":"Tiers","affiliation":[],"nameIdentifiers":[]},{"name":"Hirtz, Christophe","nameType":"Personal","givenName":"Christophe","familyName":"Hirtz","affiliation":[],"nameIdentifiers":[]},{"name":"Lehmann, Sylvain","nameType":"Personal","givenName":"Sylvain","familyName":"Lehmann","affiliation":[],"nameIdentifiers":[]},{"name":"Perrochia, Hélène","nameType":"Personal","givenName":"Hélène","familyName":"Perrochia","affiliation":[],"nameIdentifiers":[]},{"name":"Bissonnette, François","nameType":"Personal","givenName":"François","familyName":"Bissonnette","affiliation":[],"nameIdentifiers":[]},{"name":"Isaac-Jacques Kadoch","affiliation":[],"nameIdentifiers":[]},{"name":"Haouzi, Delphine","nameType":"Personal","givenName":"Delphine","familyName":"Haouzi","affiliation":[],"nameIdentifiers":[]},{"name":"Hamamah, Samir","nameType":"Personal","givenName":"Samir","familyName":"Hamamah","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Human S100A10 plays a crucial role in the acquisition of the endometrial receptivity phenotype"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2016,"subjects":[{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"Physiology"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"19999 Mathematical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Mathematics","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Mathematics","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Developmental Biology"},{"subject":"Cancer"},{"subject":"Hematology"},{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Computational Biology"}],"contributors":[],"dates":[{"date":"2016-01-13","dateType":"Created"},{"date":"2016-07-13","dateType":"Updated"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/19336918.2015.1128623","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["99642 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"In assisted reproduction, about 30% of embryo implantation failures are related to inadequate endometrial receptivity. To identify molecules involved in endometrial receptivity acquisition, we investigated, using a SELDI-TOF approach, the protein expression profile of early-secretory and mid-secretory endometrium samples. Among the proteins upregulated in mid-secretory endometrium, we investigated the function of S100A10 in endometrial receptivity and implantation process. S100A10 was expressed in epithelial and stromal cells of the endometrium of fertile patients during the implantation windows. Conversely, it was downregulated in the mid-secretory endometrium of infertile patients diagnosed as non-receptive. Transcriptome analysis of human endometrial epithelial and stromal cells where S100A10 was silenced by shRNA revealed the deregulation of 37 and 256 genes, respectively, related to components of the extracellular matrix and intercellular connections. Functional annotations of these deregulated genes highlighted alterations of the leukocyte extravasation signaling and angiogenesis pathways that play a crucial role during implantation. S100A10 silencing also affected the migration of primary endometrial epithelial and stromal cells, decidualization and secretory transformation of primary endometrial stromal cells and epithelial cells respectively, and promoted apoptosis in serum-starved endometrial epithelial cells. Our findings identify S100A10 as a player in endometrial receptivity acquisition.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/articles/dataset/Human_S100A10_plays_a_crucial_role_in_the_acquisition_of_the_endometrial_receptivity_phenotype/1632864/1","contentUrl":null,"metadataVersion":9,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2016-01-13T21:20:30.000Z","registered":"2016-01-13T21:20:32.000Z","published":"2016","updated":"2020-09-04T13:50:03.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.1632864","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}