{"data":{"id":"10.6084/m9.figshare.1632855","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1632855","prefix":"10.6084","suffix":"m9.figshare.1632855","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Jiongming Lu","affiliation":[],"nameIdentifiers":[]},{"name":"Marygold, Steven J","nameType":"Personal","givenName":"Steven J","familyName":"Marygold","affiliation":[],"nameIdentifiers":[]},{"name":"Gharib, Walid H","nameType":"Personal","givenName":"Walid H","familyName":"Gharib","affiliation":[],"nameIdentifiers":[]},{"name":"Suter, Beat","nameType":"Personal","givenName":"Beat","familyName":"Suter","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"The aminoacyl-tRNA synthetases of \u003ci\u003eDrosophila melanogaster\u003c/i\u003e"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Medicine"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"69999 Biological Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2016-01-13","dateType":"Created"},{"date":"2019-06-03","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/19336934.2015.1101196","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["112386 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Aminoacyl-tRNA synthetases (aaRSs) ligate amino acids to their cognate tRNAs, allowing them to decode the triplet code during translation. Through different mechanisms aaRSs also perform several non-canonical functions in transcription, translation, apoptosis, angiogenesis and inflammation. \u003ci\u003eDrosophila\u003c/i\u003e has become a preferred system to model human diseases caused by mutations in \u003ci\u003eaaRS\u003c/i\u003e genes, to dissect effects of reduced translation or non-canonical activities, and to study aminoacylation and translational fidelity. However, the lack of a systematic annotation of this gene family has hampered such studies. Here, we report the identification of the entire set of \u003ci\u003eaaRS\u003c/i\u003e genes in the fly genome and we predict their roles based on experimental evidence and/or orthology. Further, we propose a new, systematic and logical nomenclature for aaRSs. We also review the research conducted on \u003ci\u003eDrosophila\u003c/i\u003e aaRSs to date. Together, our work provides the foundation for further research in the fly aaRS 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