{"data":{"id":"10.6084/m9.figshare.1621907","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1621907","prefix":"10.6084","suffix":"m9.figshare.1621907","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Klionsky, Daniel J","nameType":"Personal","givenName":"Daniel J","familyName":"Klionsky","affiliation":[],"nameIdentifiers":[]},{"name":"Bernard, Amélie","nameType":"Personal","givenName":"Amélie","familyName":"Bernard","affiliation":[],"nameIdentifiers":[]},{"name":"Meiyan Jin","affiliation":[],"nameIdentifiers":[]},{"name":"Ziheng Xu","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"A large-scale analysis of autophagy-related gene expression identifies new regulators of autophagy"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Developmental Biology"},{"subject":"Mathematics"},{"subject":"FOS: Mathematics","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Mathematics","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Earth and Environmental Sciences"},{"subject":"Molecular Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Microbiology"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2015-12-09","dateType":"Created"},{"date":"2015-12-10","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[],"relatedItems":[],"sizes":["3011646 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Autophagy is a pathway mediating vacuolar degradation and recycling of proteins and organelles, which plays crucial roles in cellular physiology. To ensure its proper cytoprotective function, the induction and amplitude of autophagy are tightly regulated, and defects in its regulation are associated with various diseases. Transcriptional control of autophagy is a critical aspect of autophagy regulation, which remains largely unexplored. In particular, very few transcription factors involved in the activation or repression of autophagy-related gene expression have been characterized. To identify such regulators, we analyzed the expression of representative \u003ci\u003eATG\u003c/i\u003e genes in a large collection of DNA-binding mutant deletion strains in growing conditions as well as after nitrogen or glucose starvation. This analysis identified several proteins involved in the transcriptional control of \u003ci\u003eATG\u003c/i\u003e genes. Further analyses showed a correlation between variations in expression and autophagy magnitude, thus identifying new positive and negative regulators of the autophagy pathway. By providing a detailed analysis of the regulatory network of the \u003ci\u003eATG\u003c/i\u003e genes our study paves the way for future research on autophagy regulation and signaling.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/articles/dataset/A_large_scale_analysis_of_autophagy_related_gene_expression_identifies_new_regulators_of_autophagy/1621907","contentUrl":null,"metadataVersion":4,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2015-12-09T20:39:50.000Z","registered":"2015-12-09T20:39:51.000Z","published":"2015","updated":"2020-09-04T13:59:39.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm",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