{"data":{"id":"10.6084/m9.figshare.1613543","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1613543","prefix":"10.6084","suffix":"m9.figshare.1613543","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Enroth, Stefan","nameType":"Personal","givenName":"Stefan","familyName":"Enroth","affiliation":[],"nameIdentifiers":[]},{"name":"Enroth, Sofia Bosdotter","nameType":"Personal","givenName":"Sofia Bosdotter","familyName":"Enroth","affiliation":[],"nameIdentifiers":[]},{"name":"Johansson, Åsa","nameType":"Personal","givenName":"Åsa","familyName":"Johansson","affiliation":[],"nameIdentifiers":[]},{"name":"Gyllensten, Ulf","nameType":"Personal","givenName":"Ulf","familyName":"Gyllensten","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Effect of genetic and environmental factors on protein biomarkers for common non-communicable disease and use of personally normalized plasma protein profiles (PNPPP)"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2020,"subjects":[{"subject":"Biochemistry"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Pharmacology"},{"subject":"Biotechnology"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Developmental Biology"},{"subject":"Cancer"}],"contributors":[],"dates":[{"date":"2015-11-30","dateType":"Created"},{"date":"2020-02-05","dateType":"Updated"},{"date":"2020","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.3109/1354750x.2015.1093546","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["711430 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"\u003ci\u003eObjective\u003c/i\u003e: To study the impact of genetic and lifestyle factors on protein biomarkers and develop \u003ci\u003epersonally normalized plasma protein profiles\u003c/i\u003e (PNPPP) controlling for non-disease-related variance. \u003ci\u003eMaterials and methods\u003c/i\u003e: Proximity extension assays were used to measure 145 proteins in 632 controls and 344 cases with non-communicable diseases. \u003ci\u003eResults\u003c/i\u003e: Genetic and lifestyle factors explained 20–88% of the variation in healthy controls. Adjusting for these factors reduced the number of candidate biomarkers by 63%. \u003ci\u003eConclusion\u003c/i\u003e: PNPPP efficiently controls for non-disease-related variance, allowing both for efficient discovery of novel biomarkers and for covariate-independent linear cut-offs suitable for clinical 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