{"data":{"id":"10.6084/m9.figshare.1612281","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1612281","prefix":"10.6084","suffix":"m9.figshare.1612281","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Poole, Charles","nameType":"Personal","givenName":"Charles","familyName":"Poole","affiliation":[],"nameIdentifiers":[]},{"name":"Satten, Glen A.","nameType":"Personal","givenName":"Glen A.","familyName":"Satten","affiliation":[],"nameIdentifiers":[]},{"name":"Ashley-Koch, Allison","nameType":"Personal","givenName":"Allison","familyName":"Ashley-Koch","affiliation":[],"nameIdentifiers":[]},{"name":"Napier, Melanie D.","nameType":"Personal","givenName":"Melanie D.","familyName":"Napier","affiliation":[],"nameIdentifiers":[]},{"name":"Marrie, Ruth Ann","nameType":"Personal","givenName":"Ruth Ann","familyName":"Marrie","affiliation":[],"nameIdentifiers":[]},{"name":"Dhelia M. Williamson","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Heavy metals, organic solvents, and multiple sclerosis: An exploratory look at gene-environment interactions"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"111714 Mental Health","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Ecology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Chemistry"},{"subject":"Earth and Environmental Sciences"},{"subject":"Neuroscience"},{"subject":"Genetics"},{"subject":"Biochemistry"},{"subject":"Biophysics"}],"contributors":[],"dates":[{"date":"2015-11-25","dateType":"Created"},{"date":"2015-11-25","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/19338244.2014.937381","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["457003 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"ABSTRACTExposure to heavy metals and organic solvents are potential etiologic factors for multiple sclerosis (MS), but their interaction with MS-associated genes is under-studied. The authors explored the relationship between environmental exposure to lead, mercury, and solvents and 58 single-nucleotide polymorphisms (SNPs) in MS-associated genes. Data from a population-based case-control study of 217 prevalent MS cases and 496 age-, race-, gender-, and geographically matched controls were used to fit conditional logistic regression models of the association between the chemical, gene, and MS, adjusting for education and ancestry. MS cases were more likely than controls to report lead (odds ratio [OR] = 2.03; 95% confidence interval [CI]: 1.07, 3.86) and mercury exposure (OR = 2.06; 95% CI: 1.08, 3.91). Findings of potential gene-environment interactions between SNPs in \u003ci\u003eTNF-\u003c/i\u003eα, \u003ci\u003eTNF-\u003c/i\u003eβ, TCA-β, \u003ci\u003eVDR, MBP,\u003c/i\u003e and \u003ci\u003eAPOE\u003c/i\u003e, and lead, mercury, or solvents should be considered cautiously due to limited sample size.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"PD94bWwgdmVyc2lvbj0iMS4wIiBlbmNvZGluZz0iVVRGLTgiPz4KPHJlc291cmNlIHhtbG5zPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCIgeG1sbnM6eHNpPSJodHRwOi8vd3d3LnczLm9yZy8yMDAxL1hNTFNjaGVtYS1pbnN0YW5jZSIgeHNpOnNjaGVtYUxvY2F0aW9uPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCBodHRwOi8vc2NoZW1hLmRhdGFjaXRlLm9yZy9tZXRhL2tlcm5lbC00LjEvbWV0YWRhdGEueHNkIj4KICA8aWRlbnRpZmllciBpZGVudGlmaWVyVHlwZT0iRE9JIj4xMC42MDg0L005LkZJR1NIQVJFLjE2MTIyODE8L2lkZW50aWZpZXI+CiAgPGNyZWF0b3JzPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5DaGFybGVzIFBvb2xlPC9jcmVhdG9yTmFtZT4KICAgIDwvY3JlYXRvcj4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+R2xlbiBBLiBTYXR0ZW48L2NyZWF0b3JOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5BbGxpc29uIEFzaGxleS1Lb2NoPC9jcmVhdG9yTmFtZT4KICAgIDwvY3JlYXRvcj4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+TWVsYW5pZSBELiBOYXBpZXI8L2NyZWF0b3JOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5SdXRoIEFubiBNYXJyaWU8L2NyZWF0b3JOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5EaGVsaWEgTS4gV2lsbGlhbXNvbjwvY3JlYXRvck5hbWU+CiAgICA8L2NyZWF0b3I+CiAgPC9jcmVhdG9ycz4KICA8dGl0bGVzPgogICAgPHRpdGxlPkhlYXZ5IG1ldGFscywgb3JnYW5pYyBzb2x2ZW50cywgYW5kIG11bHRpcGxlIHNjbGVyb3NpczogQW4gZXhwbG9yYXRvcnkgbG9vayBhdCBnZW5lLWVudmlyb25tZW50IGludGVyYWN0aW9uczwvdGl0bGU+CiAgPC90aXRsZXM+CiAgPGRlc2NyaXB0aW9ucz4KICAgIDxkZXNjcmlwdGlvbiBkZXNjcmlwdGlvblR5cGU9IkFic3RyYWN0Ij4mbHQ7ZGl2Jmd0OyZsdDtwJmd0O0FCU1RSQUNUJmx0Oy9wJmd0OyZsdDtwJmd0O0V4cG9zdXJlIHRvIGhlYXZ5IG1ldGFscyBhbmQgb3JnYW5pYyBzb2x2ZW50cyBhcmUgcG90ZW50aWFsIGV0aW9sb2dpYyBmYWN0b3JzIGZvciBtdWx0aXBsZSBzY2xlcm9zaXMgKE1TKSwgYnV0IHRoZWlyIGludGVyYWN0aW9uIHdpdGggTVMtYXNzb2NpYXRlZCBnZW5lcyBpcyB1bmRlci1zdHVkaWVkLiBUaGUgYXV0aG9ycyBleHBsb3JlZCB0aGUgcmVsYXRpb25zaGlwIGJldHdlZW4gZW52aXJvbm1lbnRhbCBleHBvc3VyZSB0byBsZWFkLCBtZXJjdXJ5LCBhbmQgc29sdmVudHMgYW5kIDU4IHNpbmdsZS1udWNsZW90aWRlIHBvbHltb3JwaGlzbXMgKFNOUHMpIGluIE1TLWFzc29jaWF0ZWQgZ2VuZXMuIERhdGEgZnJvbSBhIHBvcHVsYXRpb24tYmFzZWQgY2FzZS1jb250cm9sIHN0dWR5IG9mIDIxNyBwcmV2YWxlbnQgTVMgY2FzZXMgYW5kIDQ5NiBhZ2UtLCByYWNlLSwgZ2VuZGVyLSwgYW5kIGdlb2dyYXBoaWNhbGx5IG1hdGNoZWQgY29udHJvbHMgd2VyZSB1c2VkIHRvIGZpdCBjb25kaXRpb25hbCBsb2dpc3RpYyByZWdyZXNzaW9uIG1vZGVscyBvZiB0aGUgYXNzb2NpYXRpb24gYmV0d2VlbiB0aGUgY2hlbWljYWwsIGdlbmUsIGFuZCBNUywgYWRqdXN0aW5nIGZvciBlZHVjYXRpb24gYW5kIGFuY2VzdHJ5LiBNUyBjYXNlcyB3ZXJlIG1vcmUgbGlrZWx5IHRoYW4gY29udHJvbHMgdG8gcmVwb3J0IGxlYWQgKG9kZHMgcmF0aW8gW09SXSA9IDIuMDM7IDk1JSBjb25maWRlbmNlIGludGVydmFsIFtDSV06IDEuMDcsIDMuODYpIGFuZCBtZXJjdXJ5IGV4cG9zdXJlIChPUiA9IDIuMDY7IDk1JSBDSTogMS4wOCwgMy45MSkuIEZpbmRpbmdzIG9mIHBvdGVudGlhbCBnZW5lLWVudmlyb25tZW50IGludGVyYWN0aW9ucyBiZXR3ZWVuIFNOUHMgaW4gJmx0O2kmZ3Q7VE5GLSZsdDsvaSZndDvOsSwgJmx0O2kmZ3Q7VE5GLSZsdDsvaSZndDvOsiwgVENBLc6yLCAmbHQ7aSZndDtWRFIsIE1CUCwmbHQ7L2kmZ3Q7IGFuZCAmbHQ7aSZndDtBUE9FJmx0Oy9pJmd0OywgYW5kIGxlYWQsIG1lcmN1cnksIG9yIHNvbHZlbnRzIHNob3VsZCBiZSBjb25zaWRlcmVkIGNhdXRpb3VzbHkgZHVlIHRvIGxpbWl0ZWQgc2FtcGxlIHNpemUuJmx0Oy9wJmd0OyZsdDsvZGl2Jmd0OzwvZGVzY3JpcHRpb24+CiAgPC9kZXNjcmlwdGlvbnM+CiAgPHN1YmplY3RzPgogICAgPHN1YmplY3Qgc2NoZW1lVVJJPSJodHRwOi8vd3d3LmFicy5nb3YuYXUvYXVzc3RhdHMvYWJzQC5uc2YvMC82QkI0MjdBQjk2OTZDMjI1Q0EyNTc0MTgwMDA0NDYzRSIgc3ViamVjdFNjaGVtZT0iRk9SIj4xMTE3MTQgTWVudGFsIEhlYWx0aDwvc3ViamVjdD4KICAgIDxzdWJqZWN0PkJpb2xvZ2ljYWwgU2NpZW5jZXM8L3N1YmplY3Q+CiAgICA8c3ViamVjdD5JbW11bm9sb2d5PC9zdWJqZWN0PgogICAgPHN1YmplY3Q+RWNvbG9neTwvc3ViamVjdD4KICAgIDxzdWJqZWN0PkNoZW1pc3RyeTwvc3ViamVjdD4KICAgIDxzdWJqZWN0PkVhcnRoIGFuZCBFbnZpcm9ubWVudGFsIFNjaWVuY2VzPC9zdWJqZWN0PgogICAgPHN1YmplY3Q+TmV1cm9zY2llbmNlPC9zdWJqZWN0PgogICAgPHN1YmplY3Q+R2VuZXRpY3M8L3N1YmplY3Q+CiAgICA8c3ViamVjdD5CaW9jaGVtaXN0cnk8L3N1YmplY3Q+CiAgICA8c3ViamVjdD5CaW9waHlzaWNzPC9zdWJqZWN0PgogIDwvc3ViamVjdHM+CiAgPHB1Ymxpc2hlcj5UYXlsb3IgJmFtcDsgRnJhbmNpczwvcHVibGlzaGVyPgogIDxwdWJsaWNhdGlvblllYXI+MjAxNTwvcHVibGljYXRpb25ZZWFyPgogIDxkYXRlcz4KICAgIDxkYXRlIGRhdGVUeXBlPSJDcmVhdGVkIj4yMDE1LTExLTI1PC9kYXRlPgogICAgPGRhdGUgZGF0ZVR5cGU9IlVwZGF0ZWQiPjIwMTUtMTEtMjU8L2RhdGU+CiAgPC9kYXRlcz4KICA8cmVzb3VyY2VUeXBlIHJlc291cmNlVHlwZUdlbmVyYWw9IkRhdGFzZXQiPkRhdGFzZXQ8L3Jlc291cmNlVHlwZT4KICA8c2l6ZXM+CiAgICA8c2l6ZT40NTcwMDMgQnl0ZXM8L3NpemU+CiAgPC9zaXplcz4KICA8cmVsYXRlZElkZW50aWZpZXJzPgogICAgPHJlbGF0ZWRJZGVudGlmaWVyIHJlbGF0ZWRJZGVudGlmaWVyVHlwZT0iRE9JIiByZWxhdGlvblR5cGU9IklzU3VwcGxlbWVudFRvIj4xMC4xMDgwLzE5MzM4MjQ0LjIwMTQuOTM3MzgxPC9yZWxhdGVkSWRlbnRpZmllcj4KICA8L3JlbGF0ZWRJZGVudGlmaWVycz4KICA8cmlnaHRzTGlzdD4KICAgIDxyaWdodHMgcmlnaHRzVVJJPSJodHRwczovL2NyZWF0aXZlY29tbW9ucy5vcmcvbGljZW5zZXMvYnkvNC4wLyI+Q0MgQlkgNC4wPC9yaWdodHM+CiAgPC9yaWdodHNMaXN0Pgo8L3Jlc291cmNlPg==","url":"https://tandf.figshare.com/articles/dataset/Heavy_metals_organic_solvents_and_multiple_sclerosis_An_exploratory_look_at_gene_environment_interactions/1612281","contentUrl":null,"metadataVersion":2,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"ref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