{"data":{"id":"10.6084/m9.figshare.1612161","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1612161","prefix":"10.6084","suffix":"m9.figshare.1612161","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Christodoulides, Myron","nameType":"Personal","givenName":"Myron","familyName":"Christodoulides","affiliation":[],"nameIdentifiers":[]},{"name":"Humbert, María Victoria","nameType":"Personal","givenName":"María Victoria","familyName":"Humbert","affiliation":[],"nameIdentifiers":[]},{"name":"Hannia L Almonacid Mendoza","affiliation":[],"nameIdentifiers":[]},{"name":"Jackson, Alexandra C","nameType":"Personal","givenName":"Alexandra C","familyName":"Jackson","affiliation":[],"nameIdentifiers":[]},{"name":"Miao-Chiu Hung","affiliation":[],"nameIdentifiers":[]},{"name":"Bielecka, Magdalena K","nameType":"Personal","givenName":"Magdalena K","familyName":"Bielecka","affiliation":[],"nameIdentifiers":[]},{"name":"Heckels, John E","nameType":"Personal","givenName":"John E","familyName":"Heckels","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Vaccine potential of bacterial macrophage infectivity potentiator (MIP)-like peptidyl prolyl \u003ci\u003ecis/trans\u003c/i\u003e isomerase (PPIase) proteins"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cancer"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Chemistry"},{"subject":"Biotechnology"},{"subject":"Molecular Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Microbiology"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2015-11-25","dateType":"Created"},{"date":"2015-11-25","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1586/14760584.2015.1095638","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["1384261 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Peptidyl prolyl \u003ci\u003ecis/trans\u003c/i\u003e isomerases (PPIases) are a superfamily of proteins ubiquitously distributed among living organisms, which function primarily to assist the folding and structuring of unfolded and partially folded polypeptide chains and proteins. In this review, we focus specifically on the Macrophage Infectivity Potentiator (MIP)-like PPIases, which are members of the immunophilin family of FK506-binding proteins (FKBP). MIP-like PPIases have accessory roles in virulence and are candidates for inclusion in vaccines protective against both animal and human bacterial pathogens. A structural vaccinology approach obviates any issues over molecular mimicry and potential cross-reactivity with human FKBP proteins and studies with a representative antigen, the \u003ci\u003eNeisseria meningitidis\u003c/i\u003e-MIP, support this strategy. Moreover, a dual approach of vaccination and drug targeting could be considered for controlling bacterial infectious diseases of humans and animals.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/articles/dataset/Vaccine_potential_of_bacterial_macrophage_infectivity_potentiator_MIP_like_peptidyl_prolyl_i_cis_trans_i_isomerase_PPIase_proteins/1612161","contentUrl":null,"metadataVersion":2,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActi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