{"data":{"id":"10.6084/m9.figshare.1601938","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1601938","prefix":"10.6084","suffix":"m9.figshare.1601938","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Chen, Liang","givenName":"Liang","familyName":"Chen","affiliation":[],"nameIdentifiers":[]},{"name":"Liao, Bin","givenName":"Bin","familyName":"Liao","affiliation":[],"nameIdentifiers":[]},{"name":"Qi, Hua","givenName":"Hua","familyName":"Qi","affiliation":[],"nameIdentifiers":[]},{"name":"Xie, Li-Juan","givenName":"Li-Juan","familyName":"Xie","affiliation":[],"nameIdentifiers":[]},{"name":"Huang, Li","givenName":"Li","familyName":"Huang","affiliation":[],"nameIdentifiers":[]},{"name":"Tan, Wei-Juan","givenName":"Wei-Juan","familyName":"Tan","affiliation":[],"nameIdentifiers":[]},{"name":"Zhai, Ning","givenName":"Ning","familyName":"Zhai","affiliation":[],"nameIdentifiers":[]},{"name":"Yuan, Li-Bing","givenName":"Li-Bing","familyName":"Yuan","affiliation":[],"nameIdentifiers":[]},{"name":"Zhou, Ying","givenName":"Ying","familyName":"Zhou","affiliation":[],"nameIdentifiers":[]},{"name":"Yu, Lu-Jun","givenName":"Lu-Jun","familyName":"Yu","affiliation":[],"nameIdentifiers":[]},{"name":"Chen, Qin-Fang","givenName":"Qin-Fang","familyName":"Chen","affiliation":[],"nameIdentifiers":[]},{"name":"Shu, Wensheng","givenName":"Wensheng","familyName":"Shu","affiliation":[],"nameIdentifiers":[]},{"name":"Xiao, Shi","givenName":"Shi","familyName":"Xiao","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Autophagy contributes to regulation of the hypoxia response during submergence in \u003ci\u003eArabidopsis thaliana\u003c/i\u003e"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2018,"subjects":[{"subject":"Medicine"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"Physiology"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Developmental Biology"},{"subject":"Cancer"},{"subject":"Plant Biology"},{"subject":"Computational Biology"}],"contributors":[],"dates":[{"date":"2018-08-31","dateType":"Created"},{"date":"2023-06-03","dateType":"Updated"},{"date":"2018","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/15548627.2015.1112483","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["3741588 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Autophagy involves massive degradation of intracellular components and functions as a conserved system that helps cells to adapt to adverse conditions. In mammals, hypoxia rapidly stimulates autophagy as a cell survival response. Here, we examine the function of autophagy in the regulation of the plant response to submergence, an abiotic stress that leads to hypoxia and anaerobic respiration in plant cells. In \u003ci\u003eArabidopsis thaliana\u003c/i\u003e, submergence induces the transcription of autophagy-related (\u003ci\u003eATG\u003c/i\u003e) genes and the formation of autophagosomes. Consistent with this, the autophagy-defective (\u003ci\u003eatg\u003c/i\u003e) mutants are hypersensitive to submergence stress and treatment with ethanol, the end product of anaerobic respiration. Upon submergence, the \u003ci\u003eatg\u003c/i\u003e mutants have increased levels of transcripts of anaerobic respiration genes (\u003ci\u003ealcohol dehydrogenase 1, ADH1\u003c/i\u003e and \u003ci\u003epyruvate decarboxylase 1, PDC1\u003c/i\u003e), but reduced levels of transcripts of other hypoxia- and ethylene-responsive genes. Both submergence and ethanol treatments induce the accumulation of reactive oxygen species (ROS) in the rosettes of \u003ci\u003eatg\u003c/i\u003e mutants more than in the wild type. Moreover, the production of ROS by the nicotinamide adenine dinucleotide phosphate (NADPH) oxidases is necessary for plant tolerance to submergence and ethanol, submergence-induced expression of \u003ci\u003eADH1\u003c/i\u003e and \u003ci\u003ePDC1\u003c/i\u003e, and activation of autophagy. The submergence- and ethanol-sensitive phenotypes in the \u003ci\u003eatg\u003c/i\u003e mutants depend on a complete salicylic acid (SA) signaling pathway. Together, our findings demonstrate that submergence-induced autophagy functions in the hypoxia response in \u003ci\u003eArabidopsis\u003c/i\u003e by modulating SA-mediated cellular homeostasis.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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