{"data":{"id":"10.6084/m9.figshare.1601912","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1601912","prefix":"10.6084","suffix":"m9.figshare.1601912","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Popelka, Hana","nameType":"Personal","givenName":"Hana","familyName":"Popelka","affiliation":[],"nameIdentifiers":[]},{"name":"Klionsky, Daniel J","nameType":"Personal","givenName":"Daniel J","familyName":"Klionsky","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Analysis of the native conformation of the LIR/AIM motif in the Atg8/LC3/GABARAP-binding proteins"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2018,"subjects":[{"subject":"Biophysics"},{"subject":"Biochemistry"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Medicine"},{"subject":"Microbiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"Cancer"},{"subject":"Plant Biology"}],"contributors":[],"dates":[{"date":"2015-11-13","dateType":"Created"},{"date":"2019-06-03","dateType":"Updated"},{"date":"2018","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/15548627.2015.1111503","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["1397437 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"The Atg8/LC3/GABARAP family of proteins, a group that has structural homology with ubiquitin, connects with a large set of binding partners to function in macroautophagy (hereafter autophagy). This interaction occurs primarily via a conserved motif termed the LC3-interacting region (LIR), or the Atg8-interacting motif (AIM). The consensus sequence for this motif, [W/F/Y]xx[L/I/V], can be found in many proteins, but only some of them are physiological partners containing a functional LIR/AIM. Because the structure of many full-length partners has not been, or cannot be, solved, the structural context of the LIR/AIM within the native protein conformation is not obvious. Here we suggest that the functional LIR/AIM is a short linear motif (SLiM) protein-binding module, arising from an intrinsically disordered region. This finding enables the rapid elimination of some false Atg8/LC3/GABARAP-binding proteins, and connects the exponentially growing knowledge on disordered SLiMs with autophagy.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/articles/dataset/Analysis_of_the_native_conformation_of_the_LIR_AIM_motif_in_the_Atg8_LC3_GABARAP_binding_proteins/1601912","contentUrl":null,"metadataVersion":5,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2015-11-13T18:14:06.000Z","registered":"2015-11-13T18:14:07.000Z","published":"2018","updated":"2020-09-04T14:30:22.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.1601912","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}