{"data":{"id":"10.6084/m9.figshare.1600888","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1600888","prefix":"10.6084","suffix":"m9.figshare.1600888","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Metwally, Nadia Hanafy","nameType":"Personal","givenName":"Nadia Hanafy","familyName":"Metwally","affiliation":[],"nameIdentifiers":[]},{"name":"El-Doseky, Ibrahim Adel","nameType":"Personal","givenName":"Ibrahim Adel","familyName":"El-Doseky","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Facile Synthesis of Some New Pyrazole-Based 2-Thioxo-4-thiazolidinone"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Information and Computing Sciences"},{"subject":"Biological Sciences"},{"subject":"Sociology"},{"subject":"FOS: Sociology","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Sociology","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Chemistry"},{"subject":"Earth and Environmental Sciences"},{"subject":"Biotechnology"},{"subject":"Microbiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Physics"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2015-11-12","dateType":"Created"},{"date":"2015-12-03","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/00397911.2015.1100312","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["5906281 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"5-Ethoxymethylene-2-thioxo-4-thiazolidinone (\u003cb\u003e1\u003c/b\u003e) reacts with hydrazine hydrate at room temperature to afford 5-(hydrazinylmethylene)-2-thioxo-4-thiazolidinone (\u003cb\u003e3)\u003c/b\u003e. Compound \u003cb\u003e3\u003c/b\u003e condensed with different aromatic aldehydes \u003cb\u003e6a–d\u003c/b\u003e in ethanol in the presence of a few drops of piperidine to give the corresponding Schiff’s bases \u003cb\u003e7a–d\u003c/b\u003e. On the other hand, compound \u003cb\u003e3\u003c/b\u003e reacts with o-hydroxybenzaldehyde derivatives \u003cb\u003e8a\u003c/b\u003e and \u003cb\u003e8b\u003c/b\u003e in refluxing ethanol catalyzed by a few drops of piperidine to yield 1H-inadzolyl-2-thioxo-4-thiazolidinones \u003cb\u003e9a\u003c/b\u003e and \u003cb\u003e9b\u003c/b\u003e. Reaction of compound \u003cb\u003e3\u003c/b\u003e with α-ketoesters \u003cb\u003e10a\u003c/b\u003e and \u003cb\u003e10b\u003c/b\u003e or α-diketones \u003cb\u003e10c–e\u003c/b\u003e in refluxing glacial acetic acid furnished the pyrazolyl-2-thioxo-4-thiazolidinone derivatives \u003cb\u003e11a–e\u003c/b\u003e. Also, compound \u003cb\u003e3\u003c/b\u003e reacts with some different enaminones \u003cb\u003e12a–f\u003c/b\u003e in refluxing glacial acetic acid to afford the new pyrazolyl-2-thioxo-4-thiazolidinone derivatives \u003cb\u003e13a–f\u003c/b\u003e. Pyrazoles \u003cb\u003e15a–d\u003c/b\u003e was obtained via reaction of compound \u003cb\u003e3\u003c/b\u003e with chalcones \u003cb\u003e14a–d\u003c/b\u003e in dimethylformamide (DMF). The structures of all the newly synthesized products were confirmed on the basis of their elemental and spectral data, and a plausible mechanism has been postulated to account for their formation.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/articles/dataset/Facile_Synthesis_of_Some_New_Pyrazole_Based_2_Thioxo_4_thiazolidinone/1600888","contentU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