{"data":{"id":"10.6084/m9.figshare.1593223","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1593223","prefix":"10.6084","suffix":"m9.figshare.1593223","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Pontillo, Alessandra","nameType":"Personal","givenName":"Alessandra","familyName":"Pontillo","affiliation":[],"nameIdentifiers":[]},{"name":"Edione C. Reis","affiliation":[],"nameIdentifiers":[]},{"name":"Liphaus, Bernadete L.","nameType":"Personal","givenName":"Bernadete L.","familyName":"Liphaus","affiliation":[],"nameIdentifiers":[]},{"name":"Silva, Clovis A.","nameType":"Personal","givenName":"Clovis A.","familyName":"Silva","affiliation":[],"nameIdentifiers":[]},{"name":"Carneiro-Sampaio, Magda","nameType":"Personal","givenName":"Magda","familyName":"Carneiro-Sampaio","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Inflammasome polymorphisms in juvenile systemic lupus erythematosus"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Developmental Biology"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Ecology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Earth and Environmental Sciences"},{"subject":"Molecular Biology"},{"subject":"Genetics"}],"contributors":[],"dates":[{"date":"2015-11-04","dateType":"Created"},{"date":"2015-11-04","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.3109/08916934.2015.1064399","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["346963 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Inflammasome is the cytoplasmic complex responsible for pro-IL1 β cleavage and secretion of IL-1β. Recently our group reported the first association between polymorphisms in the inflammasome receptor \u003ci\u003eNLRP1\u003c/i\u003e and adult-onset systemic lupus erythematosus (SLE) “\u003ci\u003edi per se\u003c/i\u003e” and especially in SLE-associated renal disease, suggesting the involvement of NLRP1-inflammasome in the immune dysregulation characteristic of SLE patients. Considering that juvenile-onset SLE (JSLE) is more severe than adult SLE, and that the genetic background plays a major role in the early development of autoimmune diseases, we analysed selected polymorphisms in inflammasome genes (\u003ci\u003eNLRP1, NLRP3, CARD8, IL1B, TNFAIP3\u003c/i\u003e) of children and adolescents with JSLE (\u003ci\u003en\u003c/i\u003e = 90) and in healthy controls (\u003ci\u003en\u003c/i\u003e = 144). A single polymorphism in \u003ci\u003eIL1B\u003c/i\u003e, and not \u003ci\u003eNLRP1,\u003c/i\u003e gene resulted in association with JSLE, suggesting that IL-1 β is involved in the pathogenesis of SLE, but different genes could play specific role in adult- or early-onset disease.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/articles/dataset/Inflammasome_polymorphisms_in_juvenile_systemic_lupus_erythematosus/1593223","contentUrl":null,"metadataVersion":2,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2015-11-04T21:55:29.000Z","registered":"2015-11-04T21:55:30.000Z","published":"2015","updated":"2020-09-04T14:38:19.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"provi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