{"data":{"id":"10.6084/m9.figshare.1593212","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1593212","prefix":"10.6084","suffix":"m9.figshare.1593212","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Redaelli, Marco","nameType":"Personal","givenName":"Marco","familyName":"Redaelli","affiliation":[],"nameIdentifiers":[]},{"name":"Barollo, Susi","nameType":"Personal","givenName":"Susi","familyName":"Barollo","affiliation":[],"nameIdentifiers":[]},{"name":"Mian, Caterina","nameType":"Personal","givenName":"Caterina","familyName":"Mian","affiliation":[],"nameIdentifiers":[]},{"name":"Betterle, Corrado","nameType":"Personal","givenName":"Corrado","familyName":"Betterle","affiliation":[],"nameIdentifiers":[]},{"name":"Iacobone, Maurizio","nameType":"Personal","givenName":"Maurizio","familyName":"Iacobone","affiliation":[],"nameIdentifiers":[]},{"name":"Fassina, Ambrogio","nameType":"Personal","givenName":"Ambrogio","familyName":"Fassina","affiliation":[],"nameIdentifiers":[]},{"name":"Mantero, Franco","nameType":"Personal","givenName":"Franco","familyName":"Mantero","affiliation":[],"nameIdentifiers":[]},{"name":"Rubin, Beatrice","nameType":"Personal","givenName":"Beatrice","familyName":"Rubin","affiliation":[],"nameIdentifiers":[]},{"name":"Halenya Monticelli","affiliation":[],"nameIdentifiers":[]},{"name":"Mucignat, Carla","nameType":"Personal","givenName":"Carla","familyName":"Mucignat","affiliation":[],"nameIdentifiers":[]},{"name":"Bertazza, Loris","nameType":"Personal","givenName":"Loris","familyName":"Bertazza","affiliation":[],"nameIdentifiers":[]},{"name":"Boscaro, Marco","nameType":"Personal","givenName":"Marco","familyName":"Boscaro","affiliation":[],"nameIdentifiers":[]},{"name":"Pezzani, Raffaele","nameType":"Personal","givenName":"Raffaele","familyName":"Pezzani","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Mitogen-Activated Protein Kinase Pathway: Genetic Analysis of 95 Adrenocortical Tumors"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"111714 Mental Health","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Science Policy"},{"subject":"Cancer"},{"subject":"Biological Sciences"},{"subject":"Chemistry"},{"subject":"Earth and Environmental Sciences"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2015-11-04","dateType":"Created"},{"date":"2015-11-04","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.3109/07357907.2015.1080832","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["5915572 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Mitogen-activated protein kinase (MAPK) pathway is often deregulated in adrenocortical tumors (ACT) but with no concrete data confirming alteration rate. The objective of this study was to evaluate genetic alterations in key components of MAPK pathway. We found one \u003ci\u003eBRAF\u003c/i\u003e mutation (p.V600E) and four \u003ci\u003eHRAS\u003c/i\u003e silent mutations. No alteration was found in \u003ci\u003eNRAS\u003c/i\u003e, \u003ci\u003eKRAS, EGFR\u003c/i\u003e genes. The patient carrying \u003ci\u003eBRAF\u003c/i\u003e mutation was further characterized by investigating his biomolecular and clinico-pathological findings. Therefore, even if MAPK signaling is activated in ACT, our results suggest that genetic alterations do not seem to represent a frequent mechanism of ACT tumorigenesis.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/articles/dataset/Mitogen_Activated_Protein_Kinase_Pathway_Genetic_Analysis_of_95_Adrenocortical_Tumors/1593212","contentUrl":null,"metadataVersion":3,"schemaVersion":"http://dat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