{"data":{"id":"10.6084/m9.figshare.1591870","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1591870","prefix":"10.6084","suffix":"m9.figshare.1591870","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Bui, Hue T. B.","nameType":"Personal","givenName":"Hue T. B.","familyName":"Bui","affiliation":[],"nameIdentifiers":[]},{"name":"Vo, Duy D.","nameType":"Personal","givenName":"Duy D.","familyName":"Vo","affiliation":[],"nameIdentifiers":[]},{"name":"Chau, Yen N. T.","nameType":"Personal","givenName":"Yen N. T.","familyName":"Chau","affiliation":[],"nameIdentifiers":[]},{"name":"Tu, Cuc T. K.","nameType":"Personal","givenName":"Cuc T. K.","familyName":"Tu","affiliation":[],"nameIdentifiers":[]},{"name":"Mai, Hieu V.","nameType":"Personal","givenName":"Hieu V.","familyName":"Mai","affiliation":[],"nameIdentifiers":[]},{"name":"Truong, Kiet V.","nameType":"Personal","givenName":"Kiet V.","familyName":"Truong","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Facile Synthesis of 4-Oxo-4\u003ci\u003eH\u003c/i\u003e-quinolizine-2-carboxamide Derivatives"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biological Sciences"},{"subject":"Ecology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Chemistry"},{"subject":"Earth and Environmental Sciences"},{"subject":"Biotechnology"},{"subject":"Cell Biology"},{"subject":"Microbiology"},{"subject":"Medicine"},{"subject":"Engineering"},{"subject":"Biochemistry"},{"subject":"Biophysics"}],"contributors":[],"dates":[{"date":"2015-11-03","dateType":"Created"},{"date":"2015-11-03","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/00397911.2015.1112918","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["6643868 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"A facile synthetic method for the construction of 2-substituted-4-oxo-4H-quinolizine based core structure has been successfully developed. The synthesis made use of a one pot Stobbe condensation followed by cyclisation starting from the commercially available 2-pyridinecarbaldehyde. The structure of the formed 4-oxo-4H-quinolizine-2-carboxylate was fully confirmed by MS, \u003csup\u003e1\u003c/sup\u003eH NMR, \u003csup\u003e13\u003c/sup\u003eC NMR, COSY, HMBC and HSQC spectra. The ethyl carboxylate moiety was then further functionalized via direct aminolysis by a range of amines to afford the corresponding 4-oxo-4H-quinolizine-2-carboxamides \u003cb\u003e4a-i\u003c/b\u003e in moderate to good yields.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/articles/dataset/Facile_Synthesis_of_4_Oxo_4_i_H_i_quinolizine_2_carboxamide_Derivatives/1591870","contentUrl":null,"metadataVersion":3,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2015-11-03T20:34:50.000Z","registered":"2015-11-03T20:34:51.000Z","published":"2015","updated":"2020-09-04T14:39:56.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.1591870","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}