{"data":{"id":"10.6084/m9.figshare.1589777","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1589777","prefix":"10.6084","suffix":"m9.figshare.1589777","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Heydtmann, Mathis","nameType":"Personal","givenName":"Mathis","familyName":"Heydtmann","affiliation":[],"nameIdentifiers":[]},{"name":"Macdonald, Benn","nameType":"Personal","givenName":"Benn","familyName":"Macdonald","affiliation":[],"nameIdentifiers":[]},{"name":"Lewsey, James","nameType":"Personal","givenName":"James","familyName":"Lewsey","affiliation":[],"nameIdentifiers":[]},{"name":"Masson, Neil","nameType":"Personal","givenName":"Neil","familyName":"Masson","affiliation":[],"nameIdentifiers":[]},{"name":"Cunningham, Leona","nameType":"Personal","givenName":"Leona","familyName":"Cunningham","affiliation":[],"nameIdentifiers":[]},{"name":"Irnazarow, Aleksandra","nameType":"Personal","givenName":"Aleksandra","familyName":"Irnazarow","affiliation":[],"nameIdentifiers":[]},{"name":"Nardone, Amanda","nameType":"Personal","givenName":"Amanda","familyName":"Nardone","affiliation":[],"nameIdentifiers":[]},{"name":"Cosgrave, Jan","nameType":"Personal","givenName":"Jan","familyName":"Cosgrave","affiliation":[],"nameIdentifiers":[]},{"name":"Chick, Jonathan","nameType":"Personal","givenName":"Jonathan","familyName":"Chick","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Tailored dose baclofen in patients with alcoholic liver disease: A case series with 2-year follow-up of hospitalisation"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Medicine"},{"subject":"Biotechnology"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Marine Biology"},{"subject":"Cancer"},{"subject":"Science Policy"},{"subject":"60506 Virology","subjectScheme":"FOR"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Computational Biology"}],"contributors":[],"dates":[{"date":"2015-10-30","dateType":"Created"},{"date":"2016-06-29","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.3109/16066359.2015.1040003","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["704968 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"\u003ci\u003eIntroduction\u003c/i\u003e: Alcohol addiction is a major health burden with its consequences including liver disease and frequent hospitalisations. We used tailored-dose baclofen in patients with alcoholic liver disease and investigated hospital re-admissions before and after baclofen dose was initiated as well as tolerability and patient-reported alcohol consumption. \u003ci\u003eMethods\u003c/i\u003e: Fifty-three hospitalised patients with alcoholic liver disease started tailored dose baclofen (median: 5.05 months, median highest dose before tapering down: 60 mg). Patients were followed-up for hospitalisation data from the health board database (mean hospitalisation follow up: 31 months) and patients were sent standardized questionnaires. \u003ci\u003eResults\u003c/i\u003e: Baclofen was generally well tolerated with dose reductions in four patients. In the 2 years after initiation of the treatment, patients spent on an average of 19.1 d in the hospital per year compared to 25.48 d before the treatment initiation (\u003ci\u003ep\u003c/i\u003e = 0.59). Respondents (19 patients) reported a reduction in alcohol consumption by an average of 58.7% (240.1 g to 144.09 g). \u003ci\u003eConclusions\u003c/i\u003e: After initiation of the baclofen treatment, there was a trend towards decrease in hospitalisations and in patients who answered the questionnaire, alcohol consumption decreased.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/articles/dataset/Tailored_dose_baclofen_in_patients_with_alcoholic_liver_disease_A_case_series_with_2_year_follow_up_of_hospitalisation/1589777/2","contentUrl":null,"metadataVersion":5,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2015-10-30T12:06:45.000Z","registered":"2015-10-30T12:06:46.000Z","published":"2015","updated":"2020-09-04T14:44:32.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.1589777","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}