{"data":{"id":"10.6084/m9.figshare.1588542","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1588542","prefix":"10.6084","suffix":"m9.figshare.1588542","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Kozielewicz, Dorota","nameType":"Personal","givenName":"Dorota","familyName":"Kozielewicz","affiliation":[],"nameIdentifiers":[]},{"name":"Dybowska, Dorota","nameType":"Personal","givenName":"Dorota","familyName":"Dybowska","affiliation":[],"nameIdentifiers":[]},{"name":"Karwowska, Kornelia","nameType":"Personal","givenName":"Kornelia","familyName":"Karwowska","affiliation":[],"nameIdentifiers":[]},{"name":"Wietlicka-Piszcz, Magdalena","nameType":"Personal","givenName":"Magdalena","familyName":"Wietlicka-Piszcz","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Renal impairment in patients with chronic hepatitis C treated with first generation protease inhibitors"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"111714 Mental Health","subjectScheme":"FOR"},{"subject":"Cancer"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Chemistry"},{"subject":"Molecular Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Medicine"}],"contributors":[],"dates":[{"date":"2015-10-29","dateType":"Created"},{"date":"2015-10-29","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1517/14740338.2015.1102882","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["30530 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"\u003cb\u003e\u003ci\u003eBackground\u003c/i\u003e\u003c/b\u003e: The incidence, course and risk factors associated with renal impairment (RI) in patients treated with triple therapy (TT) with pegylated interferon, ribavirin and telaprevir/boceprevir (PR/TVR/BOC) vs. dual therapy (DT) with PR were analyzed in this study. The association between RI and the decline of hemoglobin (Hb) was also examined.\u003cb\u003e\u003ci\u003eMethods\u003c/i\u003e\u003c/b\u003e: Retrospective analysis included 110 patients with genotype 1b chronic HCV infection, aged 18 – 80 years, who underwent TT (48TVR/14BOC) or DT (48 patients). The estimated glomerular filtration rate (eGFR), serum creatinine concentration (SCr) and Hb were measured at baseline, at weeks 4, 12, 24, 48 of treatment, and post-treatment week 24.\u003cb\u003e\u003ci\u003eResults\u003c/i\u003e\u003c/b\u003e: RI occurred in 9/62 (14.5%) patients who underwent TT, eight of whom were treated with TVR, one with BOC, and none treated with DT. The risk factors associated with RI were the following: TT (p = 0.0078), usage of nephrotoxic drugs (p = 0.0288), and older age (p \u003cb\u003e\u003ci\u003eConclusions\u003c/i\u003e\u003c/b\u003e: RI is not a rare but a reversible complication of TT. It is necessary to monitor SCr and eGFR, especially in patients with a potential risk factor of RI occurrence. The Hb drop is more severe in patients with RI than in those without it.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"PD94bWwgdmVyc2lvbj0iMS4wIiBlbmNvZGluZz0iVVRGLTgiPz4KPHJlc291cmNlIHhtbG5zPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCIgeG1sbnM6eHNpPSJodHRwOi8vd3d3LnczLm9yZy8yMDAxL1hNTFNjaGVtYS1pbnN0YW5jZSIgeHNpOnNjaGVtYUxvY2F0aW9uPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCBodHRwOi8vc2NoZW1hLmRhdGFjaXRlLm9yZy9tZXRhL2tlcm5lbC00LjEvbWV0YWRhdGEueHNkIj4KICA8aWRlbnRpZmllciBpZGVudGlmaWVyVHlwZT0iRE9JIj4xMC42MDg0L005LkZJR1NIQVJFLjE1ODg1NDI8L2lkZW50aWZpZXI+CiAgPGNyZWF0b3JzPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5Eb3JvdGEgS296aWVsZXdpY3o8L2NyZWF0b3JOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5Eb3JvdGEgRHlib3dza2E8L2NyZWF0b3JOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5Lb3JuZWxpYSBLYXJ3b3dza2E8L2NyZWF0b3JOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5NYWdkYWxlbmEgV2lldGxpY2thLVBpc3pjejwvY3JlYXRvck5hbWU+CiAgICA8L2NyZWF0b3I+CiAgPC9jcmVhdG9ycz4KICA8dGl0bGVzPgogICAgPHRpdGxlPlJlbmFsIGltcGFpcm1lbnQgaW4gcGF0aWVudHMgd2l0aCBjaHJvbmljIGhlcGF0aXRpcyBDIHRyZWF0ZWQgd2l0aCBmaXJzdCBnZW5lcmF0aW9uIHByb3RlYXNlIGluaGliaXRvcnM8L3RpdGxlPgogIDwvdGl0bGVzPgogIDxkZXNjcmlwdGlvbnM+CiAgICA8ZGVzY3JpcHRpb24gZGVzY3JpcHRpb25UeXBlPSJBYnN0cmFjdCI+Jmx0O2RpdiZndDsmbHQ7cCZndDsmbHQ7YiZndDsmbHQ7aSZndDtCYWNrZ3JvdW5kJmx0Oy9pJmd0OyZsdDsvYiZndDs6IFRoZSBpbmNpZGVuY2UsIGNvdXJzZSBhbmQgcmlzayBmYWN0b3JzIGFzc29jaWF0ZWQgd2l0aCByZW5hbCBpbXBhaXJtZW50IChSSSkgaW4gcGF0aWVudHMgdHJlYXRlZCB3aXRoIHRyaXBsZSB0aGVyYXB5IChUVCkgd2l0aCBwZWd5bGF0ZWQgaW50ZXJmZXJvbiwgcmliYXZpcmluIGFuZCB0ZWxhcHJldmlyL2JvY2VwcmV2aXIgKFBSL1RWUi9CT0MpIHZzLiBkdWFsIHRoZXJhcHkgKERUKSB3aXRoIFBSIHdlcmUgYW5hbHl6ZWQgaW4gdGhpcyBzdHVkeS4gVGhlIGFzc29jaWF0aW9uIGJldHdlZW4gUkkgYW5kIHRoZSBkZWNsaW5lIG9mIGhlbW9nbG9iaW4gKEhiKSB3YXMgYWxzbyBleGFtaW5lZC4mbHQ7L3AmZ3Q7Jmx0O3AmZ3Q7Jmx0O2ImZ3Q7Jmx0O2kmZ3Q7TWV0aG9kcyZsdDsvaSZndDsmbHQ7L2ImZ3Q7OiBSZXRyb3NwZWN0aXZlIGFuYWx5c2lzIGluY2x1ZGVkIDExMCBwYXRpZW50cyB3aXRoIGdlbm90eXBlIDFiIGNocm9uaWMgSENWIGluZmVjdGlvbiwgYWdlZCAxOCDigJMgODDCoHllYXJzLCB3aG8gdW5kZXJ3ZW50IFRUICg0OFRWUi8xNEJPQykgb3IgRFQgKDQ4IHBhdGllbnRzKS4gVGhlIGVzdGltYXRlZCBnbG9tZXJ1bGFyIGZpbHRyYXRpb24gcmF0ZSAoZUdGUiksIHNlcnVtIGNyZWF0aW5pbmUgY29uY2VudHJhdGlvbiAoU0NyKSBhbmQgSGIgd2VyZSBtZWFzdXJlZCBhdCBiYXNlbGluZSwgYXQgd2Vla3MgNCwgMTIsIDI0LCA0OCBvZiB0cmVhdG1lbnQsIGFuZCBwb3N0LXRyZWF0bWVudCB3ZWVrIDI0LiZsdDsvcCZndDsmbHQ7cCZndDsmbHQ7YiZndDsmbHQ7aSZndDtSZXN1bHRzJmx0Oy9pJmd0OyZsdDsvYiZndDs6IFJJIG9jY3VycmVkIGluIDkvNjIgKDE0LjUlKSBwYXRpZW50cyB3aG8gdW5kZXJ3ZW50IFRULCBlaWdodCBvZiB3aG9tIHdlcmUgdHJlYXRlZCB3aXRoIFRWUiwgb25lIHdpdGggQk9DLCBhbmQgbm9uZSB0cmVhdGVkIHdpdGggRFQuIFRoZSByaXNrIGZhY3RvcnMgYXNzb2NpYXRlZCB3aXRoIFJJIHdlcmUgdGhlIGZvbGxvd2luZzogVFQgKHDCoD3CoDAuMDA3OCksIHVzYWdlIG9mIG5lcGhyb3RveGljIGRydWdzIChwwqA9wqAwLjAyODgpLCBhbmQgb2xkZXIgYWdlIChwwqAmbHQ7wqAwLjAwMDEpLiBSSSB3YXMgcmV2ZXJzaWJsZS4gQSBkcm9wIG9mIEhiIHdhcyBhc3NvY2lhdGVkIHdpdGggUkksIG9sZGVyIGFnZSBhbmQgVFQuJmx0Oy9wJmd0OyZsdDtwJmd0OyZsdDtiJmd0OyZsdDtpJmd0O0NvbmNsdXNpb25zJmx0Oy9pJmd0OyZsdDsvYiZndDs6IFJJIGlzIG5vdCBhIHJhcmUgYnV0IGEgcmV2ZXJzaWJsZSBjb21wbGljYXRpb24gb2YgVFQuIEl0IGlzIG5lY2Vzc2FyeSB0byBtb25pdG9yIFNDciBhbmQgZUdGUiwgZXNwZWNpYWxseSBpbiBwYXRpZW50cyB3aXRoIGEgcG90ZW50aWFsIHJpc2sgZmFjdG9yIG9mIFJJIG9jY3VycmVuY2UuIFRoZSBIYiBkcm9wIGlzIG1vcmUgc2V2ZXJlIGluIHBhdGllbnRzIHdpdGggUkkgdGhhbiBpbiB0aG9zZSB3aXRob3V0IGl0LiZsdDsvcCZndDsmbHQ7L2RpdiZndDs8L2Rlc2NyaXB0aW9uPgogIDwvZGVzY3JpcHRpb25zPgogIDxzdWJqZWN0cz4KICAgIDxzdWJqZWN0IHNjaGVtZVVSST0iaHR0cDovL3d3dy5hYnMuZ292LmF1L2F1c3N0YXRzL2Fic0AubnNmLzAvNkJCNDI3QUI5Njk2QzIyNUNBMjU3NDE4MDAwNDQ2M0UiIHN1YmplY3RTY2hlbWU9IkZPUiI+MTEwMzA5IEluZmVjdGlvdXMgRGlzZWFzZXM8L3N1YmplY3Q+CiAgICA8c3ViamVjdCBzY2hlbWVVUkk9Imh0dHA6Ly93d3cuYWJzLmdvdi5hdS9hdXNzdGF0cy9hYnNALm5zZi8wLzZCQjQyN0FCOTY5NkMyMjVDQTI1NzQxODAwMDQ0NjNFIiBzdWJqZWN0U2NoZW1lPSJGT1IiPjExMTcxNCBNZW50YWwgSGVhbHRoPC9zdWJqZWN0PgogICAgPHN1YmplY3Q+Q2FuY2VyPC9zdWJqZWN0PgogICAgPHN1YmplY3Q+SW1tdW5vbG9neTwvc3ViamVjdD4KICAgIDxzdWJqZWN0PkNoZW1pc3RyeTwvc3ViamVjdD4KICAgIDxzdWJqZWN0Pk1vbGVjdWxhciBCaW9sb2d5PC9zdWJqZWN0PgogICAgPHN1YmplY3Q+R2VuZXRpY3M8L3N1YmplY3Q+CiAgICA8c3ViamVjdD5NZWRpY2luZTwvc3ViamVjdD4KICA8L3N1YmplY3RzPgogIDxwdWJsaXNoZXI+VGF5bG9yICZhbXA7IEZyYW5jaXM8L3B1Ymxpc2hlcj4KICA8cHVibGljYXRpb25ZZWFyPjIwMTU8L3B1YmxpY2F0aW9uWWVhcj4KICA8ZGF0ZXM+CiAgICA8ZGF0ZSBkYXRlVHlwZT0iQ3JlYXRlZCI+MjAxNS0xMC0yOTwvZGF0ZT4KICAgIDxkYXRlIGRhdGVUeXBlPSJVcGRhdGVkIj4yMDE1LTEwLTI5PC9kYXRlPgogIDwvZGF0ZXM+CiAgPHJlc291cmNlVHlwZSByZXNvdXJjZVR5cGVHZW5lcmFsPSJEYXRhc2V0Ij5EYXRhc2V0PC9yZXNvdXJjZVR5cGU+CiAgPHNpemVzPgogICAgPHNpemU+MzA1MzAgQnl0ZXM8L3NpemU+CiAgPC9zaXplcz4KICA8cmVsYXRlZElkZW50aWZpZXJzPgogICAgPHJlbGF0ZWRJZGVudGlmaWVyIHJlbGF0ZWRJZGVudGlmaWVyVHlwZT0iRE9JIiByZWxhdGlvblR5cGU9IklzU3VwcGxlbWVudFRvIj4xMC4xNTE3LzE0NzQwMzM4LjIwMTUuMTEwMjg4MjwvcmVsYXRlZElkZW50aWZpZXI+CiAgPC9yZWxhdGVkSWRlbnRpZmllcnM+CiAgPHJpZ2h0c0xpc3Q+CiAgICA8cmlnaHRzIHJpZ2h0c1VSST0iaHR0cHM6Ly9jcmVhdGl2ZWNvbW1vbnMub3JnL2xpY2Vuc2VzL2J5LzQuMC8iPkNDIEJZIDQuMDwvcmlnaHRzPgogIDwvcmlnaHRzTGlzdD4KPC9yZXNvdXJjZT4=","url":"https://tandf.f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