{"data":{"id":"10.6084/m9.figshare.1569754","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1569754","prefix":"10.6084","suffix":"m9.figshare.1569754","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Barisic, Marin","nameType":"Personal","givenName":"Marin","familyName":"Barisic","affiliation":[],"nameIdentifiers":[]},{"name":"Maiato, Helder","nameType":"Personal","givenName":"Helder","familyName":"Maiato","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Dynein prevents erroneous kinetochore-microtubule attachments in mitosis"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Biophysics"},{"subject":"Biochemistry"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Molecular Biology"},{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2015-10-08","dateType":"Created"},{"date":"2018-09-01","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/15384101.2015.1089369","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["4041715 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Equal distribution of the genetic material during cell division relies on efficient congression of chromosomes to the metaphase plate. Prior to their alignment, the Dynein motor recruited to kinetochores transports a fraction of laterally-attached chromosomes along microtubules toward the spindle poles. By doing that, Dynein not only contributes to chromosome movements, but also prevents premature stabilization of end-on kinetochore-microtubule attachments. This is achieved by 2 parallel mechanisms: 1) Dynein-mediated poleward movement of chromosomes counteracts opposite polar-ejection forces (PEFs) on chromosome arms by the microtubule plus-end-directed motors chromokinesins. Otherwise, they could stabilize erroneous syntelic kinetochore-microtubule attachments and lead to the random ejection of chromosomes away from the spindle poles; and 2) By transporting chromosomes to the spindle poles, Dynein brings the former to the zone of highest Aurora A kinase activity, further destabilizing kinetochore-microtubule attachments. Thus, Dynein plays an important role in keeping chromosome segregation error-free by preventing premature stabilization of kinetochore-microtubule attachments near the spindle poles.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/articles/dataset/Dynein_prevents_erroneous_kinetochore_microtubule_attachments_in_mitosis/1569754","contentUrl":null,"metadataVersion":4,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2015-10-08T17:50:26.000Z","registered":"2015-10-08T17:50:28.000Z","published":"2015","updated":"2020-09-04T15:03:02.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{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