{"data":{"id":"10.6084/m9.figshare.1569691","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1569691","prefix":"10.6084","suffix":"m9.figshare.1569691","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Sharifi, Hoda","nameType":"Personal","givenName":"Hoda","familyName":"Sharifi","affiliation":[],"nameIdentifiers":[]},{"name":"Elmpt, Wouter Van","nameType":"Personal","givenName":"Wouter Van","familyName":"Elmpt","affiliation":[],"nameIdentifiers":[]},{"name":"Oberije, Cary","nameType":"Personal","givenName":"Cary","familyName":"Oberije","affiliation":[],"nameIdentifiers":[]},{"name":"Nalbantov, Georgi","nameType":"Personal","givenName":"Georgi","familyName":"Nalbantov","affiliation":[],"nameIdentifiers":[]},{"name":"Das, Marco","nameType":"Personal","givenName":"Marco","familyName":"Das","affiliation":[],"nameIdentifiers":[]},{"name":"Öllers, Michel","nameType":"Personal","givenName":"Michel","familyName":"Öllers","affiliation":[],"nameIdentifiers":[]},{"name":"Lambin, Philippe","nameType":"Personal","givenName":"Philippe","familyName":"Lambin","affiliation":[],"nameIdentifiers":[]},{"name":"Dingmans, Anne-Marie C.","nameType":"Personal","givenName":"Anne-Marie C.","familyName":"Dingmans","affiliation":[],"nameIdentifiers":[]},{"name":"Ruysscher, Dirk De","nameType":"Personal","givenName":"Dirk De","familyName":"Ruysscher","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Quantification of CT-assessed radiation-induced lung damage in lung cancer patients treated with or without chemotherapy and cetuximab"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2016,"subjects":[{"subject":"Biophysics"},{"subject":"Medicine"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"Physiology"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Developmental Biology"},{"subject":"Cancer"}],"contributors":[],"dates":[{"date":"2015-10-08","dateType":"Created"},{"date":"2016-02-29","dateType":"Updated"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.3109/0284186x.2015.1080856","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["1583562 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"\u003ci\u003eBackground and Purpose\u003c/i\u003e: Prediction models for radiation-induced lung damage (RILD) are still unsatisfactory, with clinical toxicity endpoints that are difficult to quantify objectively. We therefore evaluated RILD more objectively, quantitatively and on a continuous scale measuring the lung tissue density changes per voxel. \u003ci\u003eMaterial and methods\u003c/i\u003e: Patients treated with radiotherapy (RT) alone, sequential and concurrent chemo-RT with and without the addition of cetuximab were studied. Follow-up computed tomography (CT) scans were co-registered using deformable registration to baseline CT scans. CT density changes were correlated to the RT dose delivered in every part of the lungs. \u003ci\u003eResults\u003c/i\u003e: One hundred and seventeen lung cancer patients were included. Mean dose to tumor was 60 Gy (range 45–79.2 Gy). Dose response curves showed a linear increase in the dose region between 0 and 65 Gy having a slope (based on coefficients of the multilevel model) expressed as a lung density increase per dose of 0.86 (95% CI 0.73–0.99), 1.31 (95% CI 1.19–1.43), 1.39 (95% CI 1.28–1.50) and 2.07 (95% CI 1.93–2.21) for patients treated only with RT (N=19), sequential chemo-RT (N=30), concurrent chemo-RT (N=49), and concurrent chemo-RT with cetuximab (N=19), respectively. \u003ci\u003eConclusions\u003c/i\u003e: CT density changes allow quantitative assessment of lung damage after fractionated RT, giving complementary information to standard used clinical endpoints. Patients receiving cetuximab showed a significantly larger dose response compared with other treatments.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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