{"data":{"id":"10.6084/m9.figshare.1569603","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1569603","prefix":"10.6084","suffix":"m9.figshare.1569603","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"E Del Poggetto","affiliation":[],"nameIdentifiers":[]},{"name":"M Tanturli","affiliation":[],"nameIdentifiers":[]},{"name":"N Ben-Califa","affiliation":[],"nameIdentifiers":[]},{"name":"A Gozzini","affiliation":[],"nameIdentifiers":[]},{"name":"I Tusa","affiliation":[],"nameIdentifiers":[]},{"name":"G Cheloni","affiliation":[],"nameIdentifiers":[]},{"name":"I Marzi","affiliation":[],"nameIdentifiers":[]},{"name":"MG Cipolleschi","affiliation":[],"nameIdentifiers":[]},{"name":"Y Kashman","affiliation":[],"nameIdentifiers":[]},{"name":"D Neumann","affiliation":[],"nameIdentifiers":[]},{"name":"E Rovida","affiliation":[],"nameIdentifiers":[]},{"name":"P Dello Sbarba","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Salarin C inhibits the maintenance of chronic myeloid leukemia progenitor cells"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Biochemistry"},{"subject":"Cell Biology"},{"subject":"Molecular Biology"},{"subject":"Pharmacology"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Developmental Biology"},{"subject":"Cancer"},{"subject":"Hematology"},{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2015-10-08","dateType":"Created"},{"date":"2019-06-03","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/15384101.2015.1078029","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["54554544 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"We previously showed that incubation of chronic myeloid leukemia (CML) cells in very low oxygen selects a cell subset where the oncogenetic BCR/Abl protein is suppressed and which is thereby refractory to tyrosine kinase inhibitors used for CML therapy. In this study, salarin C, an anticancer macrolide extracted from the \u003ci\u003eFascaplysinopsis\u003c/i\u003e sponge, was tested as for its activity on CML cells, especially after their incubation in atmosphere at 0.1% oxygen. Salarin C induced mitotic cycle arrest, apoptosis and DNA damage. Salarin C also concentration-dependently inhibited the maintenance of stem cell potential in cultures in low oxygen of either CML cell lines or primary cells. Surprisingly, the drug also concentration-dependently enforced the maintenance of BCR/Abl signaling in low oxygen, an effect which was paralleled by the rescue of sensitivity of stem cell potential to IM. These results suggest a potential use of salarin C for the suppression of CML cells refractory to tyrosine kinase inhibitors","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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