{"data":{"id":"10.6084/m9.figshare.1569494.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1569494.v1","prefix":"10.6084","suffix":"m9.figshare.1569494.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Nam, Joon","nameType":"Personal","givenName":"Joon","familyName":"Nam","affiliation":[],"nameIdentifiers":[]},{"name":"Wooseong Kim","affiliation":[],"nameIdentifiers":[]},{"name":"Sunyoung Lee","affiliation":[],"nameIdentifiers":[]},{"name":"Seongkeun Jeong","affiliation":[],"nameIdentifiers":[]},{"name":"Yoo, Jin-Wook","nameType":"Personal","givenName":"Jin-Wook","familyName":"Yoo","affiliation":[],"nameIdentifiers":[]},{"name":"Kim, Min-Soo","nameType":"Personal","givenName":"Min-Soo","familyName":"Kim","affiliation":[],"nameIdentifiers":[]},{"name":"Yunjin Jung","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Dextran-5-(4-ethoxycarbonylphenylazo)salicylic acid ester, a polymeric colon-specific prodrug releasing 5-aminosalicylic acid and benzocaine, ameliorates TNBS-induced rat colitis"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Biophysics"},{"subject":"Biochemistry"},{"subject":"Microbiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"Molecular Biology"},{"subject":"Physiology"},{"subject":"Pharmacology"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Ecology"},{"subject":"Science Policy"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cancer"},{"subject":"Plant Biology"}],"contributors":[],"dates":[{"date":"2015-09-16","dateType":"Created"},{"date":"2016-12-13","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.3109/1061186x.2015.1087528","relatedIdentifierType":"DOI"},{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.1569494","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["2302152 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Local anesthetics have beneficial effects on colitis. Dextran-5-(4-ethoxycarbonylphenylazo)salicylic acid ester (Dex-5-ESA), designed as a polymeric colon-specific prodrug liberating 5-ASA and benzocaine in the large intestine, was prepared and its therapeutic activity against colitis was evaluated using a TNBS-induced rat colitis model. Dex-5-ESA liberated 5-ASA and benzocaine in the cecal contents while (bio)chemically stable in the small intestinal contents and mucosa. Oral administration of Dex-5-ESA (equivalent to 10 mg 5-ASA/kg, twice a day) alleviated colonic injury and reduced MPO activity in the inflamed colon. In parallel, pro-inflammatory mediators, COX-2, iNOS and CINC-3, elevated by TNBS-induced colitis, were substantially diminished in the inflamed colon. Dex-5-ESA was much more effective for the treatment of colitis than 5-(4-ethoxycarbonylphenylazo)salicylic acid (5-ESA) that may not deliver benzocaine to the large intestine. Our data suggest that Dex-5-ESA is a polymeric colon-specific prodrug, liberating 5-ASA and benzocaine in the target site (large intestine), probably exerting anti-colitic effects by combined action of 5-ASA and benzocaine.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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