{"data":{"id":"10.6084/m9.figshare.1569337.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1569337.v1","prefix":"10.6084","suffix":"m9.figshare.1569337.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Calefi, Atilio Sersun","nameType":"Personal","givenName":"Atilio Sersun","familyName":"Calefi","affiliation":[],"nameIdentifiers":[]},{"name":"Anderlise Borsoi","affiliation":[],"nameIdentifiers":[]},{"name":"Wanderley Moreno Quinteiro-Filho","affiliation":[],"nameIdentifiers":[]},{"name":"Ferreira, Antonio José Piantino","nameType":"Personal","givenName":"Antonio José Piantino","familyName":"Ferreira","affiliation":[],"nameIdentifiers":[]},{"name":"Claudete Serrano Astolfi-Ferreira","affiliation":[],"nameIdentifiers":[]},{"name":"Florio, Jorge Camilo","nameType":"Personal","givenName":"Jorge Camilo","familyName":"Florio","affiliation":[],"nameIdentifiers":[]},{"name":"Palermo-Neto, João","nameType":"Personal","givenName":"João","familyName":"Palermo-Neto","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Effects of cold stress and \u003ci\u003eSalmonella Heidelberg\u003c/i\u003e infection on bacterial load and immunity of chickens."}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"60506 Virology","subjectScheme":"FOR"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Science Policy"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Ecology"},{"subject":"Earth and Environmental Sciences"},{"subject":"Cell Biology"},{"subject":"Medicine"}],"contributors":[],"dates":[{"date":"2015-09-21","dateType":"Created"},{"date":"2016-01-20","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/03079457.2015.1086976","relatedIdentifierType":"DOI"},{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.1569337","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["0 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"We analyzed the effects of cold stress (19 ± 1°C, 6 h /day, from the 1\u003csup\u003est\u003c/sup\u003e to the 7\u003csup\u003eth\u003c/sup\u003e days of life) applied to SPF chickens. On experimental Day 1 (ED1), chicks were divided into four groups: C (not infected and kept under thermoneutral condition); CS (not infected and cold stressed); PC (\u003ci\u003eSalmonella\u003c/i\u003e Heidelberg (SH) infected and kept under thermoneutral condition) and PCS (SH infected and cold stressed). High concentrations of corticosterone were found in the cold stressed birds on ED7 and ED21, with a greater increase in birds of the PCS group. Stress or non-stressed SH-infected birds had high levels of norepinephrine on ED21. On ED21, an increased percentage and number of SH were found in birds of the PCS group. On ED7, a decrease in macrophages presenting MHCII, CD8\u003csup\u003e+\u003c/sup\u003e and CD8\u003csup\u003e+\u003c/sup\u003eγδ cells was observed in the chickens of the CS group. Decrease was observed in CD3\u003csup\u003e+\u003c/sup\u003ecells in the birds of the PCS group and increase in macrophages presenting MHCII cells and of the CD4\u003csup\u003e+\u003c/sup\u003e/CD8\u003csup\u003e+\u003c/sup\u003e ratio in chickens of the CS group on ED21. A decrease in CD8\u003csup\u003e+\u003c/sup\u003eγδ cells to birds of the CS group on ED21 and in the CD3\u003csup\u003e+\u003c/sup\u003e and CD8\u003csup\u003e+\u003c/sup\u003ecell numbers in chickens of the PCS group on ED21. Our results suggest that cold stress applied to chickens in the first 7 days of life increases both the hypothalamus pituitary adrenal axis and the sympathetic nervous system activities, leading to long-term immune cell dysfunction, thus allowing increased SH invasion and persistence within the animals’ body.Supplementary 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