{"data":{"id":"10.6084/m9.figshare.1569266.v2","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1569266.v2","prefix":"10.6084","suffix":"m9.figshare.1569266.v2","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Li, Jie","nameType":"Personal","givenName":"Jie","familyName":"Li","affiliation":[],"nameIdentifiers":[]},{"name":"Qi, Wei","nameType":"Personal","givenName":"Wei","familyName":"Qi","affiliation":[],"nameIdentifiers":[]},{"name":"Chen, Guo","nameType":"Personal","givenName":"Guo","familyName":"Chen","affiliation":[],"nameIdentifiers":[]},{"name":"Feng, Du","nameType":"Personal","givenName":"Du","familyName":"Feng","affiliation":[],"nameIdentifiers":[]},{"name":"Jinhua Liu","affiliation":[],"nameIdentifiers":[]},{"name":"Ma, Biao","nameType":"Personal","givenName":"Biao","familyName":"Ma","affiliation":[],"nameIdentifiers":[]},{"name":"Changqian Zhou","affiliation":[],"nameIdentifiers":[]},{"name":"Chenglong Mu","affiliation":[],"nameIdentifiers":[]},{"name":"Weilin Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Chen, Quan","nameType":"Personal","givenName":"Quan","familyName":"Chen","affiliation":[],"nameIdentifiers":[]},{"name":"Yushan Zhu","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Mitochondrial outer-membrane E3 ligase MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Biophysics"},{"subject":"Biochemistry"},{"subject":"Microbiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"Molecular Biology"},{"subject":"Physiology"},{"subject":"Biotechnology"},{"subject":"Evolutionary Biology"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cancer"},{"subject":"Science Policy"},{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Plant Biology"}],"contributors":[],"dates":[{"date":"2015-10-08","dateType":"Created"},{"date":"2018-08-31","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/15548627.2015.1017180","relatedIdentifierType":"DOI"},{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.1569266","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["2893569 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Mitochondria serve as membrane sources and signaling platforms for regulating autophagy. Accumulating evidence has also shown that damaged mitochondria are removed through both selective mitophagy and general autophagy in response to mitochondrial and oxidative stresses. Protein ubiquitination through mitochondrial E3 ligases plays an integrative role in mitochondrial outer membrane protein degradation, mitochondrial dynamics, and mitophagy. Here we showed that MUL1, a mitochondria-localized E3 ligase, regulates selenite-induced mitophagy in an ATG5 and ULK1-dependent manner. ULK1 partially translocated to mitochondria after selenite treatment and interacted with MUL1. We also demonstrated that ULK1 is a novel substrate of MUL1. These results suggest the association of mitochondria with autophagy regulation and provide a new mechanism for the beneficial effects of selenium as a chemopreventive agent.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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