{"data":{"id":"10.6084/m9.figshare.1569121.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1569121.v1","prefix":"10.6084","suffix":"m9.figshare.1569121.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Esmaeilzadeh, Hossein","nameType":"Personal","givenName":"Hossein","familyName":"Esmaeilzadeh","affiliation":[],"nameIdentifiers":[]},{"name":"Nabavi, Mohammad","nameType":"Personal","givenName":"Mohammad","familyName":"Nabavi","affiliation":[],"nameIdentifiers":[]},{"name":"Aryan, Zahra","nameType":"Personal","givenName":"Zahra","familyName":"Aryan","affiliation":[],"nameIdentifiers":[]},{"name":"Amirzargar, Ali Akbar","nameType":"Personal","givenName":"Ali Akbar","familyName":"Amirzargar","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Pharmacogenetic tests to predict the efficacy of aspirin desensitization in patients with aspirin-exacerbated respiratory diseases; HLA-DQB302"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Science Policy"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Medicine"}],"contributors":[],"dates":[{"date":"2015-08-23","dateType":"Created"},{"date":"2016-01-20","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1586/17476348.2015.1081062","relatedIdentifierType":"DOI"},{"relationType":"IsPreviousVersionOf","relatedIdentifier":"10.6084/m9.figshare.1569121","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["29040 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"This study is aimed at investigating the association of \u003ci\u003eHLA-DRB1,\u003c/i\u003e\u003ci\u003eHLA-DQA1,\u003c/i\u003e and \u003ci\u003eHLA\u003c/i\u003e-\u003ci\u003eDQB1\u003c/i\u003e variability with the response to aspirin desensitization (AD). A total of 16 patients with aspirin-exacerbated respiratory diseases (AERD, 81.3% were female) with median age of 29 ± 4.3 years were included in this study. Following 6 months, Sino-Nasal Outcome Test-22 (SNOT-22), medication, symptom scores, and forced expiratory volume in 1 s (FEV1) (all p \u0026lt; 0.001) improved significantly. However, only seven patients (43.7%) had clinically significant improvement in all of the medication and symptom scores and FEV1, who were considered responders to AD. Responders to AD had significantly higher symptom scores compared with non-responders at baseline (20 ± 1.18 vs 10 ± 1.27; p = 0.003). \u003ci\u003eHLADQB1*0302\u003c/i\u003e was significantly lower in non-responders than in responders to AD (0.12 [0.02–0.76]; p = 0.022). Sensitivity and specificity of HLA-DQB1*0302 to predict response to AD was 71.4% (95% CI: 35.8–91.7) and 81.8% (95% CI: 52.3–94.8). This study introduces \u003ci\u003eHLA-DQB1*0302\u003c/i\u003e as a genetic marker for favorable response to AD.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/articles/dataset/Pharmacogenetic_tests_to_predict_the_efficacy_of_aspirin_desensitization_in_patients_with_aspirin_exacerbated_respiratory_diseases_HLA_DQB302/1569121/1","contentUrl":null,"metadataVersion":3,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2016-01-20T07:37:39.000Z","registered":"2016-01-20T07:3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