{"data":{"id":"10.6084/m9.figshare.1568865","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1568865","prefix":"10.6084","suffix":"m9.figshare.1568865","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Meems, Laura M. G.","nameType":"Personal","givenName":"Laura M. G.","familyName":"Meems","affiliation":[],"nameIdentifiers":[]},{"name":"Borst, Martin H. De","nameType":"Personal","givenName":"Martin H. De","familyName":"Borst","affiliation":[],"nameIdentifiers":[]},{"name":"Postma, Dirkje S.","nameType":"Personal","givenName":"Dirkje S.","familyName":"Postma","affiliation":[],"nameIdentifiers":[]},{"name":"Vonk, Judith M.","nameType":"Personal","givenName":"Judith M.","familyName":"Vonk","affiliation":[],"nameIdentifiers":[]},{"name":"Kremer, Hubertus P. H.","nameType":"Personal","givenName":"Hubertus P. H.","familyName":"Kremer","affiliation":[],"nameIdentifiers":[]},{"name":"Marie-Louise A. Schuttelaar","affiliation":[],"nameIdentifiers":[]},{"name":"Rosmalen, Judith G. M.","nameType":"Personal","givenName":"Judith G. M.","familyName":"Rosmalen","affiliation":[],"nameIdentifiers":[]},{"name":"Weersma, Rinse K.","nameType":"Personal","givenName":"Rinse K.","familyName":"Weersma","affiliation":[],"nameIdentifiers":[]},{"name":"Wolffenbuttel, Bruce H. R.","nameType":"Personal","givenName":"Bruce H. R.","familyName":"Wolffenbuttel","affiliation":[],"nameIdentifiers":[]},{"name":"Scholtens, Salome","nameType":"Personal","givenName":"Salome","familyName":"Scholtens","affiliation":[],"nameIdentifiers":[]},{"name":"Stolk, Ronald P.","nameType":"Personal","givenName":"Ronald P.","familyName":"Stolk","affiliation":[],"nameIdentifiers":[]},{"name":"Kema, Ido P.","nameType":"Personal","givenName":"Ido P.","familyName":"Kema","affiliation":[],"nameIdentifiers":[]},{"name":"Navis, Gerjan","nameType":"Personal","givenName":"Gerjan","familyName":"Navis","affiliation":[],"nameIdentifiers":[]},{"name":"Khan, Mohsin A. F.","nameType":"Personal","givenName":"Mohsin A. F.","familyName":"Khan","affiliation":[],"nameIdentifiers":[]},{"name":"Harst, Pim Van Der","nameType":"Personal","givenName":"Pim Van Der","familyName":"Harst","affiliation":[],"nameIdentifiers":[]},{"name":"Boer, Rudolf A. De","nameType":"Personal","givenName":"Rudolf A. De","familyName":"Boer","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Low levels of vitamin D are associated with multimorbidity: Results from the LifeLines Cohort Study"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Science Policy"},{"subject":"Cancer"},{"subject":"Mathematics"},{"subject":"FOS: Mathematics","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Mathematics","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biological Sciences"},{"subject":"Medicine"}],"contributors":[],"dates":[{"date":"2015-10-08","dateType":"Created"},{"date":"2015-12-03","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.3109/07853890.2015.1073347","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["712244 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"\u003ci\u003eBackground.\u003c/i\u003e The prevalence of multimorbidity (≥ 1 disease within an individual) is rapidly increasing. So far, studies on the relationship between vitamin D and morbidity are mainly focusing on effects on single disease domains only, while vitamin D biology is associated with several diseases throughout the human body.\u003ci\u003eMethods.\u003c/i\u003e We studied 8,726 participants from the LifeLines Cohort Study (a cross-sectional, population-based cohort study) and used the self-developed composite morbidity score to study the association between vitamin D levels and multimorbidity.\u003ci\u003eResults.\u003c/i\u003e Study participants (mean age 45 ± 13 years, 73% females) had a mean plasma vitamin D level of 59 ± 22 nmol/L. In participants aged between 50 and 60 years, 58% had ≥ 2 affected disease domains, while morbidity score increased with age (70–80 years: 82% morbidity score \u0026gt; 1; \u0026gt; 80 years: 89% morbidity score \u0026gt; 1). Each incremental reduction by 1 standard deviation (SD) of vitamin D level was associated with an 8% higher morbidity score (full model OR 0.92, 95% CI 0.88–0.97, \u003ci\u003eP = \u003c/i\u003e 0.001). Participants with vitamin D levels \u0026lt; 25 nmol/L were at highest risk for increasing morbidity prevalence (versus \u0026gt; 80 nmol/L, OR 1.34, 95% CI 1.07–1.67, \u003ci\u003eP = \u003c/i\u003e0.01).\u003ci\u003eConclusions.\u003c/i\u003e Low levels of vitamin D are associated with higher prevalence of multimorbidity, especially in participants with vitamin D levels \u0026lt; 25 nmol/L. Collectively, our results favor a general, rather than an organ-specific, approach when assessing the impact of vitamin D deficiency.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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