{"data":{"id":"10.6084/m9.figshare.1568796","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1568796","prefix":"10.6084","suffix":"m9.figshare.1568796","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Schnell, Anna","nameType":"Personal","givenName":"Anna","familyName":"Schnell","affiliation":[],"nameIdentifiers":[]},{"name":"Sandrelli, Federica","nameType":"Personal","givenName":"Federica","familyName":"Sandrelli","affiliation":[],"nameIdentifiers":[]},{"name":"Vaclav Ranc","affiliation":[],"nameIdentifiers":[]},{"name":"Ripperger, Jürgen A.","nameType":"Personal","givenName":"Jürgen A.","familyName":"Ripperger","affiliation":[],"nameIdentifiers":[]},{"name":"Brai, Emanuele","nameType":"Personal","givenName":"Emanuele","familyName":"Brai","affiliation":[],"nameIdentifiers":[]},{"name":"Alberi, Lavinia","nameType":"Personal","givenName":"Lavinia","familyName":"Alberi","affiliation":[],"nameIdentifiers":[]},{"name":"Rainer, Gregor","nameType":"Personal","givenName":"Gregor","familyName":"Rainer","affiliation":[],"nameIdentifiers":[]},{"name":"Albrecht, Urs","nameType":"Personal","givenName":"Urs","familyName":"Albrecht","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Mice lacking circadian clock components display different mood-related behaviors and do not respond uniformly to chronic lithium treatment"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Plant Biology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"111714 Mental Health","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biological Sciences"},{"subject":"Chemistry"},{"subject":"Pharmacology"},{"subject":"Physiology"},{"subject":"Neuroscience"},{"subject":"Genetics"}],"contributors":[],"dates":[{"date":"2015-10-08","dateType":"Created"},{"date":"2015-12-03","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.3109/07420528.2015.1062024","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["574397 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Genomic studies suggest an association of circadian clock genes with bipolar disorder (BD) and lithium response in humans. Therefore, we tested mice mutant in various clock genes before and after lithium treatment in the forced swim test (FST), a rodent behavioral test used for evaluation of depressive-like states. We find that expression of circadian clock components, including \u003ci\u003ePer2, Cry1\u003c/i\u003e and \u003ci\u003eRev-erbα,\u003c/i\u003e is affected by lithium treatment, and thus, these clock components may contribute to the beneficial effects of lithium therapy. In particular, we observed that \u003ci\u003eCry1\u003c/i\u003e is important at specific times of the day to transmit lithium-mediated effects. Interestingly, the pathways involving \u003ci\u003ePer2\u003c/i\u003e and \u003ci\u003eCry1,\u003c/i\u003e which regulate the behavior in the FST and the response to lithium, are distinct as evidenced by the phosphorylation of GSK3β after lithium treatment and the modulation of dopamine levels in the striatum. Furthermore, we observed the co-existence of depressive and mania-like symptoms in \u003ci\u003eCry1\u003c/i\u003e knock-out mice, which resembles the so-called mixed state seen in BD patients. Taken together our results strengthen the concept that a defective circadian timing system may impact directly or indirectly on mood-related behaviors.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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