{"data":{"id":"10.6084/m9.figshare.1568720","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1568720","prefix":"10.6084","suffix":"m9.figshare.1568720","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Zhao, Qun","givenName":"Qun","familyName":"Zhao","affiliation":[],"nameIdentifiers":[]},{"name":"Guo, Zhanjun","givenName":"Zhanjun","familyName":"Guo","affiliation":[],"nameIdentifiers":[]},{"name":"Zhao, Yue","givenName":"Yue","familyName":"Zhao","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Huiying","givenName":"Huiying","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Yingnan","givenName":"Yingnan","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Fengbin","givenName":"Fengbin","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Ruixing","givenName":"Ruixing","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Identification of sequence polymorphisms in the D-Loop region of mitochondrial DNA as a risk factor for gastric cancer"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2014,"subjects":[{"subject":"Virology"},{"subject":"Infectious Diseases"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cancer"},{"subject":"Mathematics"},{"subject":"FOS: Mathematics","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biological Sciences"},{"subject":"Chemistry"},{"subject":"Earth and Environmental Sciences"},{"subject":"Biotechnology"},{"subject":"Molecular Biology"},{"subject":"Medicine"},{"subject":"Biophysics"}],"contributors":[],"dates":[{"date":"2014-12-10","dateType":"Created"},{"date":"2023-05-30","dateType":"Updated"},{"date":"2014","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.3109/19401736.2014.926546","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["0 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-Loop) of mitochondrial DNA (mtDNA) has been identified for their association with cancer risk in different types of cancers. We investigated the gastric cancer risk profile of D-Loop SNPs in a case-control study. The frequent alleles of nucleotides 73G/A, 235A/G, 309C/C insert, 324C/G, 16,362T/C and 16,519C/T were significantly associated with an increased risk for gastric cancer, whereas the frequent alleles of nucleotides 523–524AC/del were associated with resistance to gastric cancer. In conclusion, SNPs in the mtDNA D-Loop were found to be valuable markers for gastric cancer risk evaluation.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/articles/dataset/Identification_of_sequence_polymorphisms_in_the_D_Loop_region_of_mitochondrial_DNA_as_a_risk_factor_for_gastric_cancer/1568720","contentUrl":null,"metadataVersion":3,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isA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