{"data":{"id":"10.6084/m9.figshare.1568419.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1568419.v1","prefix":"10.6084","suffix":"m9.figshare.1568419.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Włodzimierz Łuczyński","affiliation":[],"nameIdentifiers":[]},{"name":"Grubczak, Kamil","nameType":"Personal","givenName":"Kamil","familyName":"Grubczak","affiliation":[],"nameIdentifiers":[]},{"name":"Moniuszko, Marcin","nameType":"Personal","givenName":"Marcin","familyName":"Moniuszko","affiliation":[],"nameIdentifiers":[]},{"name":"Głowińska-Olszewska, Barbara","nameType":"Personal","givenName":"Barbara","familyName":"Głowińska-Olszewska","affiliation":[],"nameIdentifiers":[]},{"name":"Bossowski, Artur","nameType":"Personal","givenName":"Artur","familyName":"Bossowski","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Elevated levels of Th17 cells in children with central obesity"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Cancer"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Chemistry"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"}],"contributors":[],"dates":[{"date":"2015-10-03","dateType":"Created"},{"date":"2016-01-20","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.3109/00365513.2015.1066845","relatedIdentifierType":"DOI"},{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.1568419","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["184832 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"\u003cb\u003e\u003ci\u003eBackground\u003c/i\u003e.\u003c/b\u003e It is believed that the recently discovered interleukin 17-producing Th17 cells play a role in the pathogenesis of chronic inflammation in the course of obesity and diabetes. \u003cb\u003e\u003ci\u003eObjectives\u003c/i\u003e.\u003c/b\u003e The purpose of our study was to complete data on this subject in children. \u003cb\u003e\u003ci\u003eMethods\u003c/i\u003e.\u003c/b\u003e We assessed Th17 cell levels in the peripheral blood of children diagnosed with central obesity (\u003ci\u003en\u003c/i\u003e = 14) and compared the results with data obtained in patients with newly diagnosed (\u003ci\u003en\u003c/i\u003e = 11) and long-term type 1 diabetes mellitus (\u003ci\u003en\u003c/i\u003e = 18), and in a control group as well (\u003ci\u003en\u003c/i\u003e = 24). \u003cb\u003e\u003ci\u003eResults\u003c/i\u003e.\u003c/b\u003e (i) Children with central obesity were characterized by higher percentages of Th17 cells as compared to children from the control group; (ii) in the peripheral blood of patients with long-term type 1 diabetes the Th17 cell counts were higher compared to the control group; (iii) total plasma cholesterol concentration correlated positively with Th17/Treg cells ratio; and (iv) among patients with long-term diabetes, disease duration correlated positively with Th17 cell count and Th17/Th1 cell ratio. \u003cb\u003e\u003ci\u003eConclusion\u003c/i\u003e.\u003c/b\u003e The results of our study indicate that Th17 cells may be involved in chronic inflammation accompanying obesity and type 1 diabetes mellitus in children.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/articles/dataset/Elevated_levels_of_Th17_cells_in_children_with_central_obesity/1568419/1","contentUrl":null,"metadataVersion":2,"schemaVersion":"http://d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