{"data":{"id":"10.6084/m9.figshare.1568364.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1568364.v1","prefix":"10.6084","suffix":"m9.figshare.1568364.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Borroni, Barbara","nameType":"Personal","givenName":"Barbara","familyName":"Borroni","affiliation":[],"nameIdentifiers":[]},{"name":"Kamphuis, Willem","nameType":"Personal","givenName":"Willem","familyName":"Kamphuis","affiliation":[],"nameIdentifiers":[]},{"name":"Padovani, Alessandro","nameType":"Personal","givenName":"Alessandro","familyName":"Padovani","affiliation":[],"nameIdentifiers":[]},{"name":"Bueno, Patricia De Godoy","nameType":"Personal","givenName":"Patricia De Godoy","familyName":"Bueno","affiliation":[],"nameIdentifiers":[]},{"name":"Luca, Monica Di","nameType":"Personal","givenName":"Monica Di","familyName":"Luca","affiliation":[],"nameIdentifiers":[]},{"name":"Cominetti, Márcia Regina","nameType":"Personal","givenName":"Márcia Regina","familyName":"Cominetti","affiliation":[],"nameIdentifiers":[]},{"name":"Manzine, Patricia Regina","nameType":"Personal","givenName":"Patricia Regina","familyName":"Manzine","affiliation":[],"nameIdentifiers":[]},{"name":"Marcello, Elena","nameType":"Personal","givenName":"Elena","familyName":"Marcello","affiliation":[],"nameIdentifiers":[]},{"name":"Hol, Elly","nameType":"Personal","givenName":"Elly","familyName":"Hol","affiliation":[],"nameIdentifiers":[]},{"name":"Nascimento, Carla Crispim","nameType":"Personal","givenName":"Carla Crispim","familyName":"Nascimento","affiliation":[],"nameIdentifiers":[]},{"name":"Vale, Francisco Assis Carvalho","nameType":"Personal","givenName":"Francisco Assis Carvalho","familyName":"Vale","affiliation":[],"nameIdentifiers":[]},{"name":"Pavarini, Sofia Cristina Iost","nameType":"Personal","givenName":"Sofia Cristina Iost","familyName":"Pavarini","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Hematology"},{"subject":"111714 Mental Health","subjectScheme":"FOR"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Chemistry"},{"subject":"Neuroscience"},{"subject":"Molecular Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2015-04-03","dateType":"Created"},{"date":"2016-01-20","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.3109/1354750x.2015.1062554","relatedIdentifierType":"DOI"},{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.1568364","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["1929974 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"ADAM10 is a potential biomarker for Alzheimer's disease (AD). ADAM10 protein levels are reduced in platelets of AD patients. The aim was to verify the total blood and platelet ADAM10 gene expression in AD patients and to compare with mild cognitive impairment (MCI) and healthy subjects. No significant differences in ADAM10 gene expression were observed. Therefore, the decrease of ADAM10 protein in platelets of AD patients is not caused by a reduction in ADAM10 mRNA. Further studies must be performed to investigate other pathways in the down regulation of ADAM10 protein.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.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