{"data":{"id":"10.6084/m9.figshare.1568349.v3","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1568349.v3","prefix":"10.6084","suffix":"m9.figshare.1568349.v3","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Ziyaad Dangor","affiliation":[],"nameIdentifiers":[]},{"name":"Gaurav Kwatra","affiliation":[],"nameIdentifiers":[]},{"name":"Izu, Alane","nameType":"Personal","givenName":"Alane","familyName":"Izu","affiliation":[],"nameIdentifiers":[]},{"name":"Adrian, Peter","nameType":"Personal","givenName":"Peter","familyName":"Adrian","affiliation":[],"nameIdentifiers":[]},{"name":"Cutland, Clare L","nameType":"Personal","givenName":"Clare L","familyName":"Cutland","affiliation":[],"nameIdentifiers":[]},{"name":"Sithembiso Velaphi","affiliation":[],"nameIdentifiers":[]},{"name":"Daynia Ballot","affiliation":[],"nameIdentifiers":[]},{"name":"Reubenson, Gary","nameType":"Personal","givenName":"Gary","familyName":"Reubenson","affiliation":[],"nameIdentifiers":[]},{"name":"Zell, Elizabeth R","nameType":"Personal","givenName":"Elizabeth R","familyName":"Zell","affiliation":[],"nameIdentifiers":[]},{"name":"Lala, Sanjay G","nameType":"Personal","givenName":"Sanjay G","familyName":"Lala","affiliation":[],"nameIdentifiers":[]},{"name":"Madhi, Shabir A","nameType":"Personal","givenName":"Shabir A","familyName":"Madhi","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Association between maternal Group B Streptococcus surface-protein antibody concentrations and invasive disease in their infants"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Inorganic Chemistry"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cancer"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Chemistry"},{"subject":"Biotechnology"},{"subject":"Physiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Microbiology"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2015-11-25","dateType":"Created"},{"date":"2016-01-20","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1586/14760584.2015.1085307","relatedIdentifierType":"DOI"},{"relationType":"IsPreviousVersionOf","relatedIdentifier":"10.6084/m9.figshare.1568349","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["78816 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Objectives: Group B Streptococcus (GBS) surface-proteins have been shown to be immunogenic and potential vaccine candidates. We aim to determine the association between maternal IgG antibodies to select GBS surface-proteins and invasive GBS disease in their infants. Methods: Using a matched case–control study, maternal antibody levels for GBS-immunogenic bacterial adhesin, fibrinogen-binding protein A and pilus-island (PI) PI-1, PI-2a, PI-2b were compared between infants with invasive GBS disease and well-baby controls. Results: The absolute risk of disease did not differ between cases and colonized controls with increasing antibody concentrations for these surface-proteins. There was, however, a relative risk reduction in invasive disease associated with fibrinogen-binding protein A, with an adjusted odds ratio of 0.04 (95% CI: 0.01–0.69) at antibody levels ≥10,000 AU/ml. Conclusion: We have not demonstrated an association between naturally occurring fibrinogen-binding protein A, GBS-immunogenic bacterial adhesin, and PI surface-protein antibodies and the risk of invasive disease in young infants. These surface-proteins may not be suitable GBS vaccine candidates.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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