{"data":{"id":"10.6084/m9.figshare.1568337.v4","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1568337.v4","prefix":"10.6084","suffix":"m9.figshare.1568337.v4","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Ladoire, Sylvain","nameType":"Personal","givenName":"Sylvain","familyName":"Ladoire","affiliation":[],"nameIdentifiers":[]},{"name":"Penault-Llorca, Frédérique","nameType":"Personal","givenName":"Frédérique","familyName":"Penault-Llorca","affiliation":[],"nameIdentifiers":[]},{"name":"Senovilla, Laura","nameType":"Personal","givenName":"Laura","familyName":"Senovilla","affiliation":[],"nameIdentifiers":[]},{"name":"Dalban, Cécile","nameType":"Personal","givenName":"Cécile","familyName":"Dalban","affiliation":[],"nameIdentifiers":[]},{"name":"Enot, David","nameType":"Personal","givenName":"David","familyName":"Enot","affiliation":[],"nameIdentifiers":[]},{"name":"Locher, Clara","nameType":"Personal","givenName":"Clara","familyName":"Locher","affiliation":[],"nameIdentifiers":[]},{"name":"Prada, Nicole","nameType":"Personal","givenName":"Nicole","familyName":"Prada","affiliation":[],"nameIdentifiers":[]},{"name":"Vichnou Poirier-Colame","affiliation":[],"nameIdentifiers":[]},{"name":"Kariman Chaba","affiliation":[],"nameIdentifiers":[]},{"name":"Arnould, Laurent","nameType":"Personal","givenName":"Laurent","familyName":"Arnould","affiliation":[],"nameIdentifiers":[]},{"name":"Ghiringhelli, François","nameType":"Personal","givenName":"François","familyName":"Ghiringhelli","affiliation":[],"nameIdentifiers":[]},{"name":"Fumoleau, Pierre","nameType":"Personal","givenName":"Pierre","familyName":"Fumoleau","affiliation":[],"nameIdentifiers":[]},{"name":"Spielmann, Marc","nameType":"Personal","givenName":"Marc","familyName":"Spielmann","affiliation":[],"nameIdentifiers":[]},{"name":"Delaloge, Suzette","nameType":"Personal","givenName":"Suzette","familyName":"Delaloge","affiliation":[],"nameIdentifiers":[]},{"name":"Poillot, Marie Laure","nameType":"Personal","givenName":"Marie Laure","familyName":"Poillot","affiliation":[],"nameIdentifiers":[]},{"name":"Arveux, Patrick","nameType":"Personal","givenName":"Patrick","familyName":"Arveux","affiliation":[],"nameIdentifiers":[]},{"name":"Goubar, Aicha","nameType":"Personal","givenName":"Aicha","familyName":"Goubar","affiliation":[],"nameIdentifiers":[]},{"name":"Andre, Fabrice","nameType":"Personal","givenName":"Fabrice","familyName":"Andre","affiliation":[],"nameIdentifiers":[]},{"name":"Zitvogel, Laurence","nameType":"Personal","givenName":"Laurence","familyName":"Zitvogel","affiliation":[],"nameIdentifiers":[]},{"name":"Kroemer, Guido","nameType":"Personal","givenName":"Guido","familyName":"Kroemer","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Combined evaluation of LC3B puncta and HMGB1 expression predicts residual risk of relapse after adjuvant chemotherapy in breast cancer"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Hematology"},{"subject":"Cancer"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biotechnology"},{"subject":"Physiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"Cell Biology"},{"subject":"Medicine"}],"contributors":[],"dates":[{"date":"2015-10-30","dateType":"Created"},{"date":"2019-06-03","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/15548627.2015.1082022","relatedIdentifierType":"DOI"},{"relationType":"IsPreviousVersionOf","relatedIdentifier":"10.6084/m9.figshare.1568337","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["5383611 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"In spite of adjuvant chemotherapy, a significant fraction of patients with localized breast cancer (BC) relapse after optimal treatment. We determined the occurrence of cytoplasmic MAP1LC3B/LC3B (microtubule-associated protein 1 light chain 3B)-positive puncta, as well as the presence of nuclear HMGB1 (high mobility group box 1) in cancer cells within surgical BC specimens by immunohistochemistry, first in a test cohort (152 patients) and then in a validation cohort of localized BC patients who all received adjuvant anthracycline-based chemotherapy (1646 patients). Cytoplasmic LC3B\u003csup\u003e+\u003c/sup\u003e puncta inversely correlated with the intensity of SQSTM1 staining, suggesting that a high percentage cells of LC3B\u003csup\u003e+\u003c/sup\u003e puncta reflects increased autophagic flux. After setting optimal thresholds in the test cohort, cytoplasmic LC3B\u003csup\u003e+\u003c/sup\u003e puncta and nuclear HMGB1 were scored as positive in 27.2% and 28.6% of the tumors, respectively, in the validation cohort, while 8.7% were considered as double positive. LC3B\u003csup\u003e+\u003c/sup\u003e puncta or HMGB1 expression alone did not constitute independent prognostic factors for metastasis-free survival (MFS) in multivariate analyses. However, the combined positivity for LC3B\u003csup\u003e+\u003c/sup\u003e puncta and nuclear HMGB1 constituted an independent prognostic factor significantly associated with prolonged MFS (hazard ratio: 0.49 95% confidence interval [0.26–0.89]; \u003ci\u003eP\u003c/i\u003e = 0.02), and improved breast cancer specific survival (hazard ratio: 0.21 95% confidence interval [0.05–0.85]; \u003ci\u003eP\u003c/i\u003e = 0.029). Subgroup analyses revealed that within patients with poor-prognosis BC, HMGB1\u003csup\u003e+\u003c/sup\u003e LC3B\u003csup\u003e+\u003c/sup\u003e double-positive tumors had a better prognosis than BC that lacked one or both of these markers. Altogether, these results suggest that the combined positivity for LC3B\u003csup\u003e+\u003c/sup\u003e puncta and nuclear HMGB1 is a positive predictor for longer BC survival.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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