{"data":{"id":"10.6084/m9.figshare.1568322","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1568322","prefix":"10.6084","suffix":"m9.figshare.1568322","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Thor, Maria","nameType":"Personal","givenName":"Maria","familyName":"Thor","affiliation":[],"nameIdentifiers":[]},{"name":"Olsson, Caroline E.","nameType":"Personal","givenName":"Caroline E.","familyName":"Olsson","affiliation":[],"nameIdentifiers":[]},{"name":"Oh, Jung Hun","nameType":"Personal","givenName":"Jung Hun","familyName":"Oh","affiliation":[],"nameIdentifiers":[]},{"name":"Petersen, Stine E.","nameType":"Personal","givenName":"Stine E.","familyName":"Petersen","affiliation":[],"nameIdentifiers":[]},{"name":"Alsadius, David","nameType":"Personal","givenName":"David","familyName":"Alsadius","affiliation":[],"nameIdentifiers":[]},{"name":"Bentzen, Lise","nameType":"Personal","givenName":"Lise","familyName":"Bentzen","affiliation":[],"nameIdentifiers":[]},{"name":"Pettersson, Niclas","nameType":"Personal","givenName":"Niclas","familyName":"Pettersson","affiliation":[],"nameIdentifiers":[]},{"name":"Muren, Ludvig P.","nameType":"Personal","givenName":"Ludvig P.","familyName":"Muren","affiliation":[],"nameIdentifiers":[]},{"name":"Ann-Charlotte Waldenström","affiliation":[],"nameIdentifiers":[]},{"name":"Høyer, Morten","nameType":"Personal","givenName":"Morten","familyName":"Høyer","affiliation":[],"nameIdentifiers":[]},{"name":"Steineck, Gunnar","nameType":"Personal","givenName":"Gunnar","familyName":"Steineck","affiliation":[],"nameIdentifiers":[]},{"name":"Deasy, Joseph O.","nameType":"Personal","givenName":"Joseph O.","familyName":"Deasy","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Relationships between dose to the gastro-intestinal tract and patient-reported symptom domains after radiotherapy for localized prostate cancer"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Molecular Biology"},{"subject":"Computational Biology"},{"subject":"60506 Virology","subjectScheme":"FOR"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cancer"},{"subject":"Biological Sciences"},{"subject":"Biotechnology"},{"subject":"Pharmacology"},{"subject":"Genetics"},{"subject":"Cell Biology"},{"subject":"Medicine"}],"contributors":[],"dates":[{"date":"2015-10-08","dateType":"Created"},{"date":"2015-12-03","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.3109/0284186x.2015.1063779","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["82598 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"ABSTRACT\u003cb\u003eBackground.\u003c/b\u003e Gastrointestinal (GI) morbidity after radiotherapy (RT) for prostate cancer is typically addressed by studying specific single symptoms. The aim of this study was to explore the interplay between domains of patient- reported outcomes (PROs) on GI morbidity, and to what extent these are explained by RT dose to the GI tract.\u003cb\u003eMaterial and methods.\u003c/b\u003e The study included men from two Scandinavian studies (N = 211/277) who had undergone primary external beam radiotherapy (EBRT) for localized prostate cancer to 70–78 Gy (2 Gy/fraction). Factor analysis was applied to previously identified PRO-based symptom domains from two study-specific questionnaires. Number of questions: 43; median time to follow-up: 3.6–6.4 years) and dose-response outcome variables were defined from these domains. Dose/volume parameters of the anal sphincter (AS) or the rectum were tested as predictors for each outcome variable using logistic regression with 10-fold cross-validation. Performance was assessed using area under the receiver operating characteristic curve (A\u003csub\u003ez\u003c/sub\u003e) and model frequency.\u003cb\u003eResults.\u003c/b\u003e Outcome variables from \u003ci\u003eDefecation urgency\u003c/i\u003e (number of symptoms: 2–3), \u003ci\u003eFecal leakage\u003c/i\u003e (4–6), \u003ci\u003eMucous\u003c/i\u003e (4), and \u003ci\u003ePain\u003c/i\u003e (3–6) were defined. In both cohorts, intermediate rectal doses predicted \u003ci\u003eDefecation urgency\u003c/i\u003e (mean A\u003csub\u003ez\u003c/sub\u003e: 0.53–0.54; Frequency: 70–75%), and near minimum and low AS doses predicted \u003ci\u003eFecal leakage\u003c/i\u003e (mean A\u003csub\u003ez\u003c/sub\u003e: 0.63–0.67; Frequency: 83–99%). In one cohort, high AS doses predicted \u003ci\u003eMucous\u003c/i\u003e (mean A\u003csub\u003ez\u003c/sub\u003e: 0.54; Frequency: 96%), whereas in the other, low AS doses and intermediate rectal doses predicted \u003ci\u003ePain\u003c/i\u003e (mean A\u003csub\u003ez\u003c/sub\u003e: 0.69; Frequency: 28–82%).\u003cb\u003eConclusion.\u003c/b\u003e We have demonstrated that \u003ci\u003eDefecation urgency, Fecal leakage, Mucous\u003c/i\u003e, and \u003ci\u003ePain\u003c/i\u003e following primary EBRT for localized prostate cancer primarily are predicted by intermediate rectal doses, low AS doses, high AS doses, or a combination of low AS and intermediate rectal doses, respectively. This suggests that there is a domain-specific dose-response for the GI tract. To reduce risk of GI morbidity, dose distributions of both the AS region and the rectum should, therefore, be considered when prescribing prostate cancer RT.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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