{"data":{"id":"10.6084/m9.figshare.1568244.v3","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1568244.v3","prefix":"10.6084","suffix":"m9.figshare.1568244.v3","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"A.R. Rabiatul","affiliation":[],"nameIdentifiers":[]},{"name":"Y. Lokanathan","affiliation":[],"nameIdentifiers":[]},{"name":"C.M. Rohaina","affiliation":[],"nameIdentifiers":[]},{"name":"S.R. Chowdhury","affiliation":[],"nameIdentifiers":[]},{"name":"B.S. Aminuddin","affiliation":[],"nameIdentifiers":[]},{"name":"B.H.I. Ruszymah","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Surface modification of electrospun poly(methyl methacrylate) (PMMA) nanofibers for the development of \u003ci\u003ein vitro\u003c/i\u003e respiratory epithelium model"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Cancer"},{"subject":"Developmental Biology"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Earth and Environmental Sciences"},{"subject":"Cell Biology"},{"subject":"Microbiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Medicine"},{"subject":"Engineering"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2015-10-13","dateType":"Created"},{"date":"2016-01-20","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/09205063.2015.1088183","relatedIdentifierType":"DOI"},{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.1568244","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["4960624 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Scaffold design is an important aspect of \u003ci\u003ein vitro\u003c/i\u003e model development. In this study, nanoscaffold surface modification, namely UV radiation and genipin cross-linking to immobilize collagen on the surface of electrospun poly (methyl methacrylate) (PMMA) nanofiber sheet was investigated. Samples were divided into four groups; PMMA nanofibers (PMMA), collagen-coated PMMA nanofibers (PMMACOL), genipin cross-linked collagen-coated PMMA nanofibers (PMMAGEN), and UV-irradiated collagen-coated PMMA nanofibers (PMMAUV). 6 h of UV radiation significantly reduced the hydrophobicity of PMMA nanofibers from (131.88° ± 1.33°) to (110.04° ± 0.27°) (\u003ci\u003ep\u003c/i\u003e p 4 ± 2.77 × 10\u003csup\u003e4\u003c/sup\u003e cells/cm\u003csup\u003e2\u003c/sup\u003e) and it has the highest proliferation rate from day 4 to 9 (0.005 ± 0.003 h\u003csup\u003e−1\u003c/sup\u003e) compared to the other groups. Even though PMMAGEN group showed the highest collagen adsorption, in terms of cells attachment and proliferation, PMMAUV group showed a better outcome compared to the other groups. Thus, PMMAUV scaffold is more suitable to be used in the construction of \u003ci\u003ein vitro\u003c/i\u003e respiratory epithelial model.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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