{"data":{"id":"10.6084/m9.figshare.1454519","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1454519","prefix":"10.6084","suffix":"m9.figshare.1454519","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Parets, Sasha E","nameType":"Personal","givenName":"Sasha E","familyName":"Parets","affiliation":[],"nameIdentifiers":[]},{"name":"Conneely, Karen N","nameType":"Personal","givenName":"Karen N","familyName":"Conneely","affiliation":[],"nameIdentifiers":[]},{"name":"Varun Kilaru","affiliation":[],"nameIdentifiers":[]},{"name":"Ramkumar Menon","affiliation":[],"nameIdentifiers":[]},{"name":"Smith, Alicia K","nameType":"Personal","givenName":"Alicia K","familyName":"Smith","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"DNA methylation provides insight into intergenerational risk for preterm birth in African Americans"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Medicine"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biotechnology"},{"subject":"59999 Environmental Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Earth and related environmental sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Earth and related environmental sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"19999 Mathematical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Mathematics","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Mathematics","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cancer"},{"subject":"111714 Mental Health","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Hematology"},{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"}],"contributors":[],"dates":[{"date":"2015-06-19","dateType":"Created"},{"date":"2016-03-11","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/15592294.2015.1062964","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["1287446 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"African Americans are at increased risk for spontaneous preterm birth (PTB). Though PTB is heritable, genetic studies have not identified variants that account for its intergenerational risk, prompting the hypothesis that epigenetic factors may also contribute. The objective of this study was to evaluate DNA methylation from maternal leukocytes to identify patterns specific to PTB and its intergenerational risk. DNA from peripheral leukocytes from African American women that delivered preterm (24–34 weeks; N = 16) or at term (39–41 weeks; N = 24) was assessed for DNA methylation using the HumanMethylation450 BeadChip. In maternal samples, 17,829 CpG sites associated with PTB, but no CpG site remained associated after correction for multiple comparisons. Examination of paired maternal-fetal samples identified 5,171 CpG sites in which methylation of maternal samples correlated with methylation of her respective fetus (FDR \u0026lt; 0.05). These correlated sites were enriched for association with PTB in maternal leukocytes. The majority of correlated CpG sites could be attributed to one or more genetic variants. They were also significantly more likely to be in genes involved in metabolic, cardiovascular, and immune pathways, suggesting a role for genetic and environmental contributions to PTB risk and chronic disease. The results of this study may provide insight into the factors underlying intergenerational risk for PTB and its consequences.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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