{"data":{"id":"10.6084/m9.figshare.14495559.v4","type":"dois","attributes":{"doi":"10.6084/m9.figshare.14495559.v4","prefix":"10.6084","suffix":"m9.figshare.14495559.v4","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Murlistyarini, Sinta","givenName":"Sinta","familyName":"Murlistyarini","affiliation":[],"nameIdentifiers":[]},{"name":"aninda, Lulus Putri","givenName":"Lulus Putri","familyName":"aninda","affiliation":[],"nameIdentifiers":[]},{"name":"Aini Afridafaz, Ufida","givenName":"Ufida","familyName":"Aini Afridafaz","affiliation":[],"nameIdentifiers":[]},{"name":"Widyarti, Sri","givenName":"Sri","familyName":"Widyarti","nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9100-7544","nameIdentifierScheme":"ORCID"}],"affiliation":[]},{"name":"tri endharti, agustina","givenName":"agustina","familyName":"tri endharti","nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-2062-5740","nameIdentifierScheme":"ORCID"}],"affiliation":[]},{"name":"Wahju Sardjono, Teguh","givenName":"Teguh","familyName":"Wahju Sardjono","nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-6727-0361","nameIdentifierScheme":"ORCID"}],"affiliation":[]}],"titles":[{"title":"The combination of ADSCs and 10% PRP increase Rb protein expression on senescent human dermal fibroblasts"}],"publisher":"figshare","container":{},"publicationYear":2021,"subjects":[{"subject":"110304 Dermatology","schemeUri":"http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E","subjectScheme":"FOR"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"111702 Aged Health Care","schemeUri":"http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biomarkers"},{"subject":"111601 Cell Physiology","schemeUri":"http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E","subjectScheme":"FOR"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2021-06-02","dateType":"Created"},{"date":"2021-06-02","dateType":"Updated"},{"date":"2021","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsPreviousVersionOf","relatedIdentifier":"10.6084/m9.figshare.14495559","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["65381152 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"This study was performed \u003ci\u003ein vitro\u003c/i\u003e with a randomized sample, and non-blinded pre-and post-test control group. The primary culture of senescent HDFs was transfected with a combination of ADSCs and 10% PRP. The effect on migration was observed through the scratch test, while the effect of PRP on reversal senescence was observed through Sa-β-gal analysis and the expression of protein Rb with ELISA.The obtained data were analysed using SPSS\u003csup\u003eâ\u003c/sup\u003e\u003csup\u003e \u003c/sup\u003e\u003csup\u003e \u003c/sup\u003esoftware version 25 (IBM). The normality test was carried out by the Shapiro Wilk test. If the P-value \u0026gt;0.05, then the normality assumption was fulfilled so an independent t-test was carried out. However, if the normality test was not fulfilled, the Mann-Whitney test was performed.\u003cbr\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"PD94bWwgdmVyc2lvbj0iMS4wIiBlbmNvZGluZz0iVVRGLTgiPz4KPHJlc291cmNlIHhtbG5zPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCIgeG1sbnM6eHNpPSJodHRwOi8vd3d3LnczLm9yZy8yMDAxL1hNTFNjaGVtYS1pbnN0YW5jZSIgeHNpOnNjaGVtYUxvY2F0aW9uPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCBodHRwOi8vc2NoZW1hLmRhdGFjaXRlLm9yZy9tZXRhL2tlcm5lbC00LjEvbWV0YWRhdGEueHNkIj4KICA8aWRlbnRpZmllciBpZGVudGlmaWVyVHlwZT0iRE9JIj4xMC42MDg0L005LkZJR1NIQVJFLjE0NDk1NTU5LlY0PC9pZGVudGlmaWVyPgogIDxjcmVhdG9ycz4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+U2ludGEgTXVybGlzdHlhcmluaTwvY3JlYXRvck5hbWU+CiAgICAgIDxnaXZlbk5hbWU+U2ludGE8L2dpdmVuTmFtZT4KICAgICAgPGZhbWlseU5hbWU+TXVybGlzdHlhcmluaTwvZmFtaWx5TmFtZT4KICAgIDwvY3JlYXRvcj4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+THVsdXMgUHV0cmkgYW5pbmRhPC9jcmVhdG9yTmFtZT4KICAgICAgPGdpdmVuTmFtZT5MdWx1cyBQdXRyaTwvZ2l2ZW5OYW1lPgogICAgICA8ZmFtaWx5TmFtZT5hbmluZGE8L2ZhbWlseU5hbWU+CiAgICA8L2NyZWF0b3I+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPlVmaWRhIEFpbmkgQWZyaWRhZmF6PC9jcmVhdG9yTmFtZT4KICAgICAgPGdpdmVuTmFtZT5VZmlkYTwvZ2l2ZW5OYW1lPgogICAgICA8ZmFtaWx5TmFtZT5BaW5pIEFmcmlkYWZhejwvZmFtaWx5TmFtZT4KICAgIDwvY3JlYXRvcj4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+U3JpIFdpZHlhcnRpPC9jcmVhdG9yTmFtZT4KICAgICAgPGdpdmVuTmFtZT5Tcmk8L2dpdmVuTmFtZT4KICAgICAgPGZhbWlseU5hbWU+V2lkeWFydGk8L2ZhbWlseU5hbWU+CiAgICAgIDxuYW1lSWRlbnRpZmllciBuYW1lSWRlbnRpZmllclNjaGVtZT0iT1JDSUQiIHNjaGVtZVVSST0iaHR0cDovL29yY2lkLm9yZyI+MDAwMC0wMDAyLTkxMDAtNzU0NDwvbmFtZUlkZW50aWZpZXI+CiAgICA8L2NyZWF0b3I+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPmFndXN0aW5hIHRyaSBlbmRoYXJ0aTwvY3JlYXRvck5hbWU+CiAgICAgIDxnaXZlbk5hbWU+YWd1c3RpbmE8L2dpdmVuTmFtZT4KICAgICAgPGZhbWlseU5hbWU+dHJpIGVuZGhhcnRpPC9mYW1pbHlOYW1lPgogICAgICA8bmFtZUlkZW50aWZpZXIgbmFtZUlkZW50aWZpZXJTY2hlbWU9Ik9SQ0lEIiBzY2hlbWVVUkk9Imh0dHA6Ly9vcmNpZC5vcmciPjAwMDAtMDAwMi0yMDYyLTU3NDA8L25hbWVJZGVudGlmaWVyPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5UZWd1aCBXYWhqdSBTYXJkam9ubzwvY3JlYXRvck5hbWU+CiAgICAgIDxnaXZlbk5hbWU+VGVndWg8L2dpdmVuTmFtZT4KICAgICAgPGZhbWlseU5hbWU+V2FoanUgU2FyZGpvbm88L2ZhbWlseU5hbWU+CiAgICAgIDxuYW1lSWRlbnRpZmllciBuYW1lSWRlbnRpZmllclNjaGVtZT0iT1JDSUQiIHNjaGVtZVVSST0iaHR0cDovL29yY2lkLm9yZyI+MDAwMC0wMDAxLTY3MjctMDM2MTwvbmFtZUlkZW50aWZpZXI+CiAgICA8L2NyZWF0b3I+CiAgPC9jcmVhdG9ycz4KICA8dGl0bGVzPgogICAgPHRpdGxlPlRoZSBjb21iaW5hdGlvbiBvZiBBRFNDcyBhbmQgMTAlIFBSUCBpbmNyZWFzZSBSYiBwcm90ZWluIGV4cHJlc3Npb24gb24gc2VuZXNjZW50IGh1bWFuIGRlcm1hbCBmaWJyb2JsYXN0czwvdGl0bGU+CiAgPC90aXRsZXM+CiAgPGRlc2NyaXB0aW9ucz4KICAgIDxkZXNjcmlwdGlvbiBkZXNjcmlwdGlvblR5cGU9IkFic3RyYWN0Ij4mbHQ7cCZndDtUaGlzIHN0dWR5IHdhcyBwZXJmb3JtZWQgJmx0O2kmZ3Q7aW4gdml0cm8mbHQ7L2kmZ3Q7IHdpdGggYSByYW5kb21pemVkIHNhbXBsZSwgYW5kIG5vbi1ibGluZGVkCnByZS1hbmQgcG9zdC10ZXN0IGNvbnRyb2wgZ3JvdXAuIFRoZSBwcmltYXJ5IGN1bHR1cmUgb2Ygc2VuZXNjZW50IEhERnMgd2FzIHRyYW5zZmVjdGVkCndpdGggYSBjb21iaW5hdGlvbiBvZiBBRFNDcyBhbmQgMTAlIFBSUC4gVGhlIGVmZmVjdCBvbiBtaWdyYXRpb24gd2FzIG9ic2VydmVkCnRocm91Z2ggdGhlIHNjcmF0Y2ggdGVzdCwgd2hpbGUgdGhlIGVmZmVjdCBvZiBQUlAgb24gcmV2ZXJzYWwgc2VuZXNjZW5jZSB3YXMKb2JzZXJ2ZWQgdGhyb3VnaCBTYS3Osi1nYWwKYW5hbHlzaXMgYW5kIHRoZSBleHByZXNzaW9uIG9mIHByb3RlaW4gUmIgd2l0aCBFTElTQS4mbHQ7L3AmZ3Q7Jmx0O3AmZ3Q7Jmx0Oy9wJmd0OyZsdDtwJmd0O1RoZSBvYnRhaW5lZApkYXRhIHdlcmUgYW5hbHlzZWQgdXNpbmcgJmx0O2EgaHJlZj0iaHR0cHM6Ly93d3cuaWJtLmNvbS91ay1lbi9wcm9kdWN0cy9zcHNzLXN0YXRpc3RpY3MiJmd0O1NQU1MmbHQ7L2EmZ3Q7Jmx0O3N1cCZndDvDoiZsdDsvc3VwJmd0OyZsdDtzdXAmZ3Q7ICZsdDsvc3VwJmd0OyZsdDtzdXAmZ3Q7ICZsdDsvc3VwJmd0O3NvZnR3YXJlIHZlcnNpb24gMjUgKElCTSkuIFRoZSBub3JtYWxpdHkgdGVzdAp3YXMgY2FycmllZCBvdXQgYnkgdGhlIFNoYXBpcm8gV2lsayB0ZXN0LiBJZiB0aGUgUC12YWx1ZSAmZ3Q7MC4wNSwgdGhlbiB0aGUKbm9ybWFsaXR5IGFzc3VtcHRpb24gd2FzIGZ1bGZpbGxlZCBzbyBhbiBpbmRlcGVuZGVudCB0LXRlc3Qgd2FzIGNhcnJpZWQgb3V0LiBIb3dldmVyLAppZiB0aGUgbm9ybWFsaXR5IHRlc3Qgd2FzIG5vdCBmdWxmaWxsZWQsIHRoZSBNYW5uLVdoaXRuZXkgdGVzdCB3YXMgcGVyZm9ybWVkLiZsdDsvcCZndDsmbHQ7YnImZ3Q7Jmx0O3AmZ3Q7Jmx0Oy9wJmd0OzwvZGVzY3JpcHRpb24+CiAgPC9kZXNjcmlwdGlvbnM+CiAgPHN1YmplY3RzPgogICAgPHN1YmplY3Qgc2NoZW1lVVJJPSJodHRwOi8vd3d3LmFicy5nb3YuYXUvYXVzc3RhdHMvYWJzQC5uc2YvMC82QkI0MjdBQjk2OTZDMjI1Q0EyNTc0MTgwMDA0NDYzRSIgc3ViamVjdFNjaGVtZT0iRk9SIj4xMTAzMDQgRGVybWF0b2xvZ3k8L3N1YmplY3Q+CiAgICA8c3ViamVjdCBzY2hlbWVVUkk9Imh0dHA6Ly93d3cuYWJzLmdvdi5hdS9hdXNzdGF0cy9hYnNALm5zZi8wLzZCQjQyN0FCOTY5NkMyMjVDQTI1NzQxODAwMDQ0NjNFIiBzdWJqZWN0U2NoZW1lPSJGT1IiPjExMTcwMiBBZ2VkIEhlYWx0aCBDYXJlPC9zdWJqZWN0PgogICAgPHN1YmplY3Q+QmlvbWFya2Vyczwvc3ViamVjdD4KICAgIDxzdWJqZWN0IHNjaGVtZVVSST0iaHR0cDovL3d3dy5hYnMuZ292LmF1L2F1c3N0YXRzL2Fic0AubnNmLzAvNkJCNDI3QUI5Njk2QzIyNUNBMjU3NDE4MDAwNDQ2M0UiIHN1YmplY3RTY2hlbWU9IkZPUiI+MTExNjAxIENlbGwgUGh5c2lvbG9neTwvc3ViamVjdD4KICA8L3N1YmplY3RzPgogIDxwdWJsaXNoZXI+Zmlnc2hhcmU8L3B1Ymxpc2hlcj4KICA8cHVibGljYXRpb25ZZWFyPjIwMjE8L3B1YmxpY2F0aW9uWWVhcj4KICA8ZGF0ZXM+CiAgICA8ZGF0ZSBkYXRlVHlwZT0iQ3JlYXRlZCI+MjAyMS0wNi0wMjwvZGF0ZT4KICAgIDxkYXRlIGRhdGVUeXBlPSJVcGRhdGVkIj4yMDIxLTA2LTAyPC9kYXRlPgogIDwvZGF0ZXM+CiAgPHJlc291cmNlVHlwZSByZXNvdXJjZVR5cGVHZW5lcmFsPSJEYXRhc2V0Ij5EYXRhc2V0PC9yZXN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