{"data":{"id":"10.6084/m9.figshare.1444338","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1444338","prefix":"10.6084","suffix":"m9.figshare.1444338","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Ohba, Takuya","nameType":"Personal","givenName":"Takuya","familyName":"Ohba","affiliation":[],"nameIdentifiers":[]},{"name":"Yoshino, Yuta","nameType":"Personal","givenName":"Yuta","familyName":"Yoshino","affiliation":[],"nameIdentifiers":[]},{"name":"Mitsue Ishisaka","affiliation":[],"nameIdentifiers":[]},{"name":"Abe, Naohito","nameType":"Personal","givenName":"Naohito","familyName":"Abe","affiliation":[],"nameIdentifiers":[]},{"name":"Tsuruma, Kazuhiro","nameType":"Personal","givenName":"Kazuhiro","familyName":"Tsuruma","affiliation":[],"nameIdentifiers":[]},{"name":"Shimazawa, Masamitsu","nameType":"Personal","givenName":"Masamitsu","familyName":"Shimazawa","affiliation":[],"nameIdentifiers":[]},{"name":"Oyama, Masayoshi","nameType":"Personal","givenName":"Masayoshi","familyName":"Oyama","affiliation":[],"nameIdentifiers":[]},{"name":"Tabira, Takeshi","nameType":"Personal","givenName":"Takeshi","familyName":"Tabira","affiliation":[],"nameIdentifiers":[]},{"name":"Hara, Hideaki","nameType":"Personal","givenName":"Hideaki","familyName":"Hara","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Japanese \u003ci\u003eHuperzia serrata\u003c/i\u003e extract and the constituent, huperzine A, ameliorate the scopolamine-induced cognitive impairment in mice"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"60506 Virology","subjectScheme":"FOR"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"111714 Mental Health","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biological Sciences"},{"subject":"Chemistry"},{"subject":"Earth and Environmental Sciences"},{"subject":"Biotechnology"},{"subject":"Pharmacology"},{"subject":"Neuroscience"},{"subject":"Molecular Biology"},{"subject":"Cell Biology"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2015-06-10","dateType":"Created"},{"date":"2015-12-03","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/09168451.2015.1052773","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["84170 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"\u003ci\u003eHuperzia serrata\u003c/i\u003e has been used as a Chinese folk medicine for many years. It contains huperzine A, which has a protective effect against memory deficits in animal models; however, it is unclear if \u003ci\u003eH. serrata\u003c/i\u003e extract exerts any effects in Alzheimer’s disease (AD) models. We used \u003ci\u003eH. serrata\u003c/i\u003e collected in Japan and determined its huperzine A content using HPLC. We determined its inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activity. \u003ci\u003eH. serrata\u003c/i\u003e extract (30 mg/kg/day) and donepezil (10 mg/kg/day) were orally administrated for 7 days. After repeated administration, we performed the Y-maze and passive avoidance tests. \u003ci\u003eH. serrata\u003c/i\u003e extract contained 0.5% huperzine A; \u003ci\u003eH. serrata\u003c/i\u003e extract inhibited AChE, but not BuChE. \u003ci\u003eH. serrata\u003c/i\u003e extract ameliorated cognitive function in mice. These results indicate that Japanese \u003ci\u003eH. serrata\u003c/i\u003e extract ameliorates cognitive function deficits by inhibiting AChE. Therefore, \u003ci\u003eH. serrata\u003c/i\u003e extract may be valuable for the prevention or treatment of dementia in AD.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"PD94bWwgdmVyc2lvbj0iMS4wIiBlbmNvZGluZz0iVVRGLTgiPz4KPHJlc291cmNlIHhtbG5zPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCIgeG1sbnM6eHNpPSJodHRwOi8vd3d3LnczLm9yZy8yMDAxL1hNTFNjaGVtYS1pbnN0YW5jZSIgeHNpOnNjaGVtYUxvY2F0aW9uPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCBodHRwOi8vc2NoZW1hLmRhdGFjaXRlLm9yZy9tZXRhL2tlcm5lbC00LjEvbWV0YWRhdGEueHNkIj4KICA8aWRlbnRpZmllciBpZGVudGlmaWVyVHlwZT0iRE9JIj4xMC42MDg0L005LkZJR1NIQVJFLjE0NDQzMzg8L2lkZW50aWZpZXI+CiAgPGNyZWF0b3JzPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5UYWt1eWEgT2hiYTwvY3JlYXRvck5hbWU+CiAgICA8L2NyZWF0b3I+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPll1dGEgWW9zaGlubzwvY3JlYXRvck5hbWU+CiAgICA8L2NyZWF0b3I+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPk1pdHN1ZSBJc2hpc2FrYTwvY3JlYXRvck5hbWU+CiAgICA8L2NyZWF0b3I+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPk5hb2hpdG8gQWJlPC9jcmVhdG9yTmFtZT4KICAgIDwvY3JlYXRvcj4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWU+S2F6dWhpcm8gVHN1cnVtYTwvY3JlYXRvck5hbWU+CiAgICA8L2NyZWF0b3I+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPk1hc2FtaXRzdSBTaGltYXphd2E8L2NyZWF0b3JOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5NYXNheW9zaGkgT3lhbWE8L2NyZWF0b3JOYW1lPgogICAgPC9jcmVhdG9yPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5UYWtlc2hpIFRhYmlyYTwvY3JlYXRvck5hbWU+CiAgICA8L2NyZWF0b3I+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPkhpZGVha2kgSGFyYTwvY3JlYXRvck5hbWU+CiAgICA8L2NyZWF0b3I+CiAgPC9jcmVhdG9ycz4KICA8dGl0bGVzPgogICAgPHRpdGxlPkphcGFuZXNlICZsdDtpJmd0O0h1cGVyemlhIHNlcnJhdGEmbHQ7L2kmZ3Q7IGV4dHJhY3QgYW5kIHRoZSBjb25zdGl0dWVudCwgaHVwZXJ6aW5lIEEsIGFtZWxpb3JhdGUgdGhlIHNjb3BvbGFtaW5lLWluZHVjZWQgY29nbml0aXZlIGltcGFpcm1lbnQgaW4gbWljZTwvdGl0bGU+CiAgPC90aXRsZXM+CiAgPGRlc2NyaXB0aW9ucz4KICAgIDxkZXNjcmlwdGlvbiBkZXNjcmlwdGlvblR5cGU9IkFic3RyYWN0Ij4mbHQ7ZGl2Jmd0OyZsdDtwJmd0OyZsdDtpJmd0O0h1cGVyemlhIHNlcnJhdGEmbHQ7L2kmZ3Q7IGhhcyBiZWVuIHVzZWQgYXMgYSBDaGluZXNlIGZvbGsgbWVkaWNpbmUgZm9yIG1hbnkgeWVhcnMuIEl0IGNvbnRhaW5zIGh1cGVyemluZSBBLCB3aGljaCBoYXMgYSBwcm90ZWN0aXZlIGVmZmVjdCBhZ2FpbnN0IG1lbW9yeSBkZWZpY2l0cyBpbiBhbmltYWwgbW9kZWxzOyBob3dldmVyLCBpdCBpcyB1bmNsZWFyIGlmICZsdDtpJmd0O0guIHNlcnJhdGEmbHQ7L2kmZ3Q7IGV4dHJhY3QgZXhlcnRzIGFueSBlZmZlY3RzIGluIEFsemhlaW1lcuKAmXMgZGlzZWFzZSAoQUQpIG1vZGVscy4gV2UgdXNlZCAmbHQ7aSZndDtILiBzZXJyYXRhJmx0Oy9pJmd0OyBjb2xsZWN0ZWQgaW4gSmFwYW4gYW5kIGRldGVybWluZWQgaXRzIGh1cGVyemluZSBBIGNvbnRlbnQgdXNpbmcgSFBMQy4gV2UgZGV0ZXJtaW5lZCBpdHMgaW5oaWJpdG9yeSBlZmZlY3RzIG9uIGFjZXR5bGNob2xpbmVzdGVyYXNlIChBQ2hFKSBhbmQgYnV0eXJ5bGNob2xpbmVzdGVyYXNlIChCdUNoRSkgYWN0aXZpdHkuICZsdDtpJmd0O0guIHNlcnJhdGEmbHQ7L2kmZ3Q7IGV4dHJhY3QgKDMwwqBtZy9rZy9kYXkpIGFuZCBkb25lcGV6aWwgKDEwwqBtZy9rZy9kYXkpIHdlcmUgb3JhbGx5IGFkbWluaXN0cmF0ZWQgZm9yIDfCoGRheXMuIEFmdGVyIHJlcGVhdGVkIGFkbWluaXN0cmF0aW9uLCB3ZSBwZXJmb3JtZWQgdGhlIFktbWF6ZSBhbmQgcGFzc2l2ZSBhdm9pZGFuY2UgdGVzdHMuICZsdDtpJmd0O0guIHNlcnJhdGEmbHQ7L2kmZ3Q7IGV4dHJhY3QgY29udGFpbmVkIDAuNSUgaHVwZXJ6aW5lIEE7ICZsdDtpJmd0O0guIHNlcnJhdGEmbHQ7L2kmZ3Q7IGV4dHJhY3QgaW5oaWJpdGVkIEFDaEUsIGJ1dCBub3QgQnVDaEUuICZsdDtpJmd0O0guIHNlcnJhdGEmbHQ7L2kmZ3Q7IGV4dHJhY3QgYW1lbGlvcmF0ZWQgY29nbml0aXZlIGZ1bmN0aW9uIGluIG1pY2UuIFRoZXNlIHJlc3VsdHMgaW5kaWNhdGUgdGhhdCBKYXBhbmVzZSAmbHQ7aSZndDtILiBzZXJyYXRhJmx0Oy9pJmd0OyBleHRyYWN0IGFtZWxpb3JhdGVzIGNvZ25pdGl2ZSBmdW5jdGlvbiBkZWZpY2l0cyBieSBpbmhpYml0aW5nIEFDaEUuIFRoZXJlZm9yZSwgJmx0O2kmZ3Q7SC4gc2VycmF0YSZsdDsvaSZndDsgZXh0cmFjdCBtYXkgYmUgdmFsdWFibGUgZm9yIHRoZSBwcmV2ZW50aW9uIG9yIHRyZWF0bWVudCBvZiBkZW1lbnRpYSBpbiBBRC4mbHQ7L3AmZ3Q7Jmx0Oy9kaXYmZ3Q7PC9kZXNjcmlwdGlvbj4KICA8L2Rlc2NyaXB0aW9ucz4KICA8c3ViamVjdHM+CiAgICA8c3ViamVjdCBzY2hlbWVVUkk9Imh0dHA6Ly93d3cuYWJzLmdvdi5hdS9hdXNzdGF0cy9hYnNALm5zZi8wLzZCQjQyN0FCOTY5NkMyMjVDQTI1NzQxODAwMDQ0NjNFIiBzdWJqZWN0U2NoZW1lPSJGT1IiPjYwNTA2IFZpcm9sb2d5PC9zdWJqZWN0PgogICAgPHN1YmplY3Qgc2NoZW1lVVJJPSJodHRwOi8vd3d3LmFicy5nb3YuYXUvYXVzc3RhdHMvYWJzQC5uc2YvMC82QkI0MjdBQjk2OTZDMjI1Q0EyNTc0MTgwMDA0NDYzRSIgc3ViamVjdFNjaGVtZT0iRk9SIj4xMTE3MTQgTWVudGFsIEhlYWx0aDwvc3ViamVjdD4KICAgIDxzdWJqZWN0PkJpb2xvZ2ljYWwgU2NpZW5jZXM8L3N1YmplY3Q+CiAgICA8c3ViamVjdD5DaGVtaXN0cnk8L3N1YmplY3Q+CiAgICA8c3ViamVjdD5FYXJ0aCBhbmQgRW52aXJvbm1lbnRhbCBTY2llbmNlczwvc3ViamVjdD4KICAgIDxzdWJqZWN0PkJpb3RlY2hub2xvZ3k8L3N1YmplY3Q+CiAgICA8c3ViamVjdD5QaGFybWFjb2xvZ3k8L3N1YmplY3Q+CiAgICA8c3ViamVjdD5OZXVyb3NjaWVuY2U8L3N1YmplY3Q+CiAgICA8c3ViamVjdD5Nb2xlY3VsYXIgQmlvbG9neTwvc3ViamVjdD4KICAgIDxzdWJqZWN0PkNlbGwgQmlvbG9neTwvc3ViamVjdD4KICAgIDxzdWJqZWN0PkJpb2NoZW1pc3RyeTwvc3ViamVjdD4KICA8L3N1YmplY3RzPgogIDxwdWJsaXNoZXI+VGF5bG9yICZhbXA7IEZyYW5jaXM8L3B1Ymxpc2hlcj4KICA8cHVibGljYXRpb25ZZWFyPjIwMTU8L3B1YmxpY2F0aW9uWWVhcj4KICA8ZGF0ZXM+CiAgICA8ZGF0ZSBkYXRlVHlwZT0iQ3JlYXRlZCI+MjAxNS0wNi0xMDwvZGF0ZT4KICAgIDxkYXRlIGRhdGVUeXBlPSJVcGRhdGVkIj4yMDE1LTEyLTAzPC9kYXRlPgogIDwvZGF0ZXM+CiAgPHJlc291cmNlVHlwZSByZXNvdXJjZVR5cGVHZW5lcmFsPSJEYXRhc2V0Ij5EYXRhc2V0PC9yZXNvdXJjZVR5cGU+CiAgPHNpemVzPgogICAgPHNpemU+ODQxNzAgQnl0ZXM8L3NpemU+CiAgPC9zaXplcz4KICA8cmVsYXRlZElkZW50aWZpZXJzPgogICAgPHJlbGF0ZWRJZGVudGlmaWVyIHJlbGF0ZWRJZGVudGlmaWVyVHlwZT0iRE9JIiByZWxhdGlvblR5cGU9IklzU3VwcGxlbWVudFRv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