{"data":{"id":"10.6084/m9.figshare.1412750.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1412750.v1","prefix":"10.6084","suffix":"m9.figshare.1412750.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Fontemaggi, Giulia","nameType":"Personal","givenName":"Giulia","familyName":"Fontemaggi","affiliation":[],"nameIdentifiers":[]},{"name":"Bellissimo, Teresa","nameType":"Personal","givenName":"Teresa","familyName":"Bellissimo","affiliation":[],"nameIdentifiers":[]},{"name":"Donzelli, Sara","nameType":"Personal","givenName":"Sara","familyName":"Donzelli","affiliation":[],"nameIdentifiers":[]},{"name":"Iosue, Ilaria","nameType":"Personal","givenName":"Ilaria","familyName":"Iosue","affiliation":[],"nameIdentifiers":[]},{"name":"Benassi, Barbara","nameType":"Personal","givenName":"Barbara","familyName":"Benassi","affiliation":[],"nameIdentifiers":[]},{"name":"Bellotti, Giorgio","nameType":"Personal","givenName":"Giorgio","familyName":"Bellotti","affiliation":[],"nameIdentifiers":[]},{"name":"Blandino, Giovanni","nameType":"Personal","givenName":"Giovanni","familyName":"Blandino","affiliation":[],"nameIdentifiers":[]},{"name":"Fazi, Francesco","nameType":"Personal","givenName":"Francesco","familyName":"Fazi","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Identification of post-transcriptional regulatory networks during myeloblast-to-monocyte differentiation transition"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Hematology"},{"subject":"Cancer"},{"subject":"Developmental Biology"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Chemistry"},{"subject":"Physiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"Genetics"},{"subject":"Cell Biology"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2015-07-03","dateType":"Created"},{"date":"2016-01-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/15476286.2015.1044194","relatedIdentifierType":"DOI"},{"relationType":"IsPreviousVersionOf","relatedIdentifier":"10.6084/m9.figshare.1412750","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["2070508 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"ABSTRACTTreatment of leukemia cells with 1,25-dihydroxyvitamin D\u003csub\u003e3\u003c/sub\u003e may overcome their differentiation block and lead to the transition from myeloblasts to monocytes. To identify microRNA-mRNA networks relevant for myeloid differentiation, we profiled the expression of mRNAs and microRNAs associated to the low- and high-density ribosomal fractions in leukemic cells and in their differentiated monocytic counterpart. Intersection between mRNAs shifted across the fractions after treatment with putative target genes of modulated microRNAs showed a series of molecular networks relevant for the monocyte cell fate determination, as for example the post-transcriptional regulation of the Polo-like kinase 1 (PLK1) by miR-22-3p and let-7e-5p.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/articles/dataset/Identification_of_post_transcriptional_regulatory_networks_during_myeloblast_to_monocyte_differentiation_transition/1412750/1","contentUrl":null,"metadataVersion":4,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2016-01-19T21:10:51.000Z","registered":"2016-01-19T21:10:53.000Z","published":"2015","updated":"2020-09-04T17:31:21.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.1412750.v1","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}