{"data":{"id":"10.6084/m9.figshare.1405694","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1405694","prefix":"10.6084","suffix":"m9.figshare.1405694","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Pivovarova, Olga","nameType":"Personal","givenName":"Olga","familyName":"Pivovarova","affiliation":[],"nameIdentifiers":[]},{"name":"Loeffelholz, Christian Von","nameType":"Personal","givenName":"Christian Von","familyName":"Loeffelholz","affiliation":[],"nameIdentifiers":[]},{"name":"Ilkavets, Iryna","nameType":"Personal","givenName":"Iryna","familyName":"Ilkavets","affiliation":[],"nameIdentifiers":[]},{"name":"Sticht, Carsten","nameType":"Personal","givenName":"Carsten","familyName":"Sticht","affiliation":[],"nameIdentifiers":[]},{"name":"Zhuk, Sergei","nameType":"Personal","givenName":"Sergei","familyName":"Zhuk","affiliation":[],"nameIdentifiers":[]},{"name":"Murahovschi, Veronica","nameType":"Personal","givenName":"Veronica","familyName":"Murahovschi","affiliation":[],"nameIdentifiers":[]},{"name":"Lukowski, Sonja","nameType":"Personal","givenName":"Sonja","familyName":"Lukowski","affiliation":[],"nameIdentifiers":[]},{"name":"Döcke, Stephanie","nameType":"Personal","givenName":"Stephanie","familyName":"Döcke","affiliation":[],"nameIdentifiers":[]},{"name":"Kriebel, Jennifer","nameType":"Personal","givenName":"Jennifer","familyName":"Kriebel","affiliation":[],"nameIdentifiers":[]},{"name":"Gala, Tonia De Las Heras","nameType":"Personal","givenName":"Tonia De Las Heras","familyName":"Gala","affiliation":[],"nameIdentifiers":[]},{"name":"Malashicheva, Anna","nameType":"Personal","givenName":"Anna","familyName":"Malashicheva","affiliation":[],"nameIdentifiers":[]},{"name":"Kostareva, Anna","nameType":"Personal","givenName":"Anna","familyName":"Kostareva","affiliation":[],"nameIdentifiers":[]},{"name":"Lock, Johan F","nameType":"Personal","givenName":"Johan F","familyName":"Lock","affiliation":[],"nameIdentifiers":[]},{"name":"Stockmann, Martin","nameType":"Personal","givenName":"Martin","familyName":"Stockmann","affiliation":[],"nameIdentifiers":[]},{"name":"Grallert, Harald","nameType":"Personal","givenName":"Harald","familyName":"Grallert","affiliation":[],"nameIdentifiers":[]},{"name":"Gretz, Norbert","nameType":"Personal","givenName":"Norbert","familyName":"Gretz","affiliation":[],"nameIdentifiers":[]},{"name":"Dooley, Steven","nameType":"Personal","givenName":"Steven","familyName":"Dooley","affiliation":[],"nameIdentifiers":[]},{"name":"Pfeiffer, Andreas FH","nameType":"Personal","givenName":"Andreas FH","familyName":"Pfeiffer","affiliation":[],"nameIdentifiers":[]},{"name":"Rudovich, Natalia","nameType":"Personal","givenName":"Natalia","familyName":"Rudovich","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Modulation of insulin degrading enzyme activity and liver cell proliferation"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Biochemistry"},{"subject":"Medicine"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"Physiology"},{"subject":"Pharmacology"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"69999 Biological Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"Developmental Biology"},{"subject":"Cancer"},{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"60506 Virology","subjectScheme":"FOR"}],"contributors":[],"dates":[{"date":"2015-05-06","dateType":"Created"},{"date":"2018-08-31","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/15384101.2015.1046647","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["656957 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Diabetes mellitus type 2 (T2DM), insulin therapy, and hyperinsulinemia are independent risk factors of liver cancer. Recently, the use of a novel inhibitor of insulin degrading enzyme (IDE) was proposed as a new therapeutic strategy in T2DM. However, IDE inhibition might stimulate liver cell proliferation via increased intracellular insulin concentration. The aim of this study was to characterize effects of inhibition of IDE activity in HepG2 hepatoma cells and to analyze liver specific expression of \u003ci\u003eIDE\u003c/i\u003e in subjects with T2DM. HepG2 cells were treated with 10 nM insulin for 24 h with or without inhibition of IDE activity using \u003ci\u003eIDE\u003c/i\u003e RNAi, and cell transcriptome and proliferation rate were analyzed. Human liver samples (n = 22) were used for the gene expression profiling by microarrays. In HepG2 cells, \u003ci\u003eIDE\u003c/i\u003e knockdown changed expression of genes involved in cell cycle and apoptosis pathways. Proliferation rate was lower in \u003ci\u003eIDE\u003c/i\u003e knockdown cells than in controls. Microarray analysis revealed the decrease of hepatic \u003ci\u003eIDE\u003c/i\u003e expression in subjects with T2DM accompanied by the downregulation of the p53-dependent genes \u003ci\u003eFAS\u003c/i\u003e and \u003ci\u003eCCNG2\u003c/i\u003e, but not by the upregulation of proliferation markers \u003ci\u003eMKI67, MCM2\u003c/i\u003e and \u003ci\u003ePCNA\u003c/i\u003e. Similar results were found in the liver microarray dataset from GEO Profiles database. In conclusion, \u003ci\u003eIDE\u003c/i\u003e expression is decreased in liver of subjects with T2DM which is accompanied by the dysregulation of p53 pathway. Prolonged use of IDE inhibitors for T2DM treatment should be carefully tested in animal studies regarding its potential effect on hepatic tumorigenesis.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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