{"data":{"id":"10.6084/m9.figshare.1378939","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1378939","prefix":"10.6084","suffix":"m9.figshare.1378939","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"McCaskill, Jana","nameType":"Personal","givenName":"Jana","familyName":"McCaskill","affiliation":[],"nameIdentifiers":[]},{"name":"Pairoa Praihirunkit","affiliation":[],"nameIdentifiers":[]},{"name":"Sharp, Paul M","nameType":"Personal","givenName":"Paul M","familyName":"Sharp","affiliation":[],"nameIdentifiers":[]},{"name":"Buck, Amy H","nameType":"Personal","givenName":"Amy H","familyName":"Buck","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"RNA-mediated degradation of microRNAs: A widespread viral strategy?"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"60506 Virology","subjectScheme":"FOR"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Hematology"},{"subject":"111714 Mental Health","subjectScheme":"FOR"},{"subject":"Biological Sciences"},{"subject":"Evolutionary Biology"},{"subject":"Molecular Biology"},{"subject":"Genetics"},{"subject":"Cell Biology"}],"contributors":[],"dates":[{"date":"2015-04-14","dateType":"Created"},{"date":"2015-12-03","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/15476286.2015.1034912","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["11606 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Regulation of small RNAs by other non-coding RNAs is a ubiquitous feature of gene regulatory systems that can be exploited by viruses. Examples of this have been described in 3 different herpesviruses, where viral non-coding RNAs bind to highly abundant cellular (miRNAs), mediating their degradation: miR-27 is targeted by both murine cytomegalovirus and herpesvirus saimiri, while the miR-17 family is targeted by human cytomegalovirus. We review what is known about RNA-mediated regulation of miRNA stability and propose 3 potential roles that viral non-coding RNAs might assume to initiate the destruction of a miRNA, acting as “recruiters,” “localizers” or “exposers.” Whereas the miRNAs (miR-17 and miR-27) appear to be ancient and pre-date the common ancestor of all mammalian herpesviruses, comparative analyses of herpesvirus genomes indicate that the 3 known viral regulators of miRNA each evolved independently, and much more recently. Noting that the anti-viral activity of miRNAs might be countered by a variety of mechanisms, we propose that (i) there has been continual turnover of these mechanisms during herpesvirus evolution, and (ii) there may be many other, as yet undescribed, anti-miRNA activities encoded by other herpesviruses and indeed by viruses from other families.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/articles/dataset/RNA_mediated_degradation_of_microRNAs_A_widespread_viral_strategy_/1378939","contentUrl":null,"metadataVe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