{"data":{"id":"10.6084/m9.figshare.1378829","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1378829","prefix":"10.6084","suffix":"m9.figshare.1378829","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Fischer, Simon","nameType":"Personal","givenName":"Simon","familyName":"Fischer","affiliation":[],"nameIdentifiers":[]},{"name":"Handrick, René","nameType":"Personal","givenName":"René","familyName":"Handrick","affiliation":[],"nameIdentifiers":[]},{"name":"Armaz Aschrafi","affiliation":[],"nameIdentifiers":[]},{"name":"Otte, Kerstin","nameType":"Personal","givenName":"Kerstin","familyName":"Otte","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Unveiling the principle of microRNA-mediated redundancy in cellular pathway regulation"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Biophysics"},{"subject":"Biochemistry"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"Physiology"},{"subject":"Evolutionary Biology"},{"subject":"Developmental Biology"},{"subject":"111714 Mental Health","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Hematology"},{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"}],"contributors":[],"dates":[{"date":"2015-04-14","dateType":"Created"},{"date":"2016-08-10","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/15476286.2015.1017238","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["67526 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Understanding the multifaceted nature of microRNA (miRNA) function in mammalian cells is still a challenge. Commonly accepted principles of cooperativity and multiplicity of miRNA function imply that individual mRNAs can be targeted by several miRNAs whereas a single miRNA may concomitantly regulate a subset of different genes. However, there is a paucity of information whether multiple miRNAs regulate critical cellular events and thereby acting redundantly. To gain insight into this notion, we conducted an unbiased high-content miRNA screen by individually introducing 1139 miRNA mimics into Chinese hamster ovary (CHO) cells. We discovered that 66% of all miRNAs significantly impacted on proliferation, protein expression, apoptosis and necrosis. In summary, we provide evidence for a substantial degree of redundancy among miRNAs to maintain cellular 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