{"data":{"id":"10.6084/m9.figshare.1311751","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1311751","prefix":"10.6084","suffix":"m9.figshare.1311751","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Kiga, Kotaro","nameType":"Personal","givenName":"Kotaro","familyName":"Kiga","affiliation":[],"nameIdentifiers":[]},{"name":"Fukuda-Yuzawa, Yoko","nameType":"Personal","givenName":"Yoko","familyName":"Fukuda-Yuzawa","affiliation":[],"nameIdentifiers":[]},{"name":"Tanabe, Masanobu","nameType":"Personal","givenName":"Masanobu","familyName":"Tanabe","affiliation":[],"nameIdentifiers":[]},{"name":"Tsuji, Shoji","nameType":"Personal","givenName":"Shoji","familyName":"Tsuji","affiliation":[],"nameIdentifiers":[]},{"name":"Sasakawa, Chihiro","nameType":"Personal","givenName":"Chihiro","familyName":"Sasakawa","affiliation":[],"nameIdentifiers":[]},{"name":"Fukao, Taro","nameType":"Personal","givenName":"Taro","familyName":"Fukao","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Comprehensive silencing of target-sharing microRNAs is a mechanism for SIRT1 overexpression in cancer"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Biophysics"},{"subject":"Biochemistry"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Medicine"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"Physiology"},{"subject":"59999 Environmental Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Earth and related environmental sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Earth and related environmental sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Sociology"},{"subject":"FOS: Sociology","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Sociology","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"69999 Biological Sciences not elsewhere classified","subjectScheme":"FOR"}],"contributors":[],"dates":[{"date":"2015-10-15","dateType":"Created"},{"date":"2021-05-26","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.4161/rna.32093","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["4870001 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Overexpression of SIRT1 is frequently observed in various types of cancers, suggesting its potential role in malignancies. However, the molecular basis of how SIRT1 is elevated in cancer is less understood. Here we show that cancer-related SIRT1 overexpression is due to evasion of \u003ci\u003eSirt1\u003c/i\u003e mRNA from repression by a group of \u003ci\u003eSirt1\u003c/i\u003e-targeting microRNAs (miRNAs) that might be robustly silenced in cancer. Our comprehensive library-based screening and subsequent miRNA gene profiling revealed a housekeeping gene-like broad expression pattern and strong CpG island-association of the \u003ci\u003eSirt1\u003c/i\u003e-targeting miRNA genes. This suggests aberrant CpG DNA methylation as the mechanistic background for malignant SIRT1 elevation. Our work also provides an example where epigenetic mechanisms cause the group-wide regulation of miRNAs sharing a common key 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