{"data":{"id":"10.6084/m9.figshare.1304505","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1304505","prefix":"10.6084","suffix":"m9.figshare.1304505","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Cabrera, Javier","nameType":"Personal","givenName":"Javier","familyName":"Cabrera","affiliation":[],"nameIdentifiers":[]},{"name":"Fenoll, Carmen","nameType":"Personal","givenName":"Carmen","familyName":"Fenoll","affiliation":[],"nameIdentifiers":[]},{"name":"Escobar, Carolina","nameType":"Personal","givenName":"Carolina","familyName":"Escobar","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Genes co-regulated with \u003ci\u003eLBD16\u003c/i\u003e in nematode feeding sites inferred from \u003ci\u003ein silico\u003c/i\u003e analysis show similarities to regulatory circuits mediated by the auxin/cytokinin balance in Arabidopsis"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Plant Biology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"110309 Infectious Diseases","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cancer"},{"subject":"Developmental Biology"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Neuroscience"},{"subject":"Molecular Biology"},{"subject":"Genetics"},{"subject":"Cell Biology"},{"subject":"Microbiology"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2015-02-09","dateType":"Created"},{"date":"2015-12-03","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.4161/15592324.2014.990825","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["720977 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Plant endoparasitic nematodes, root-knot and cyst nematodes (RKNs and CNs) induce within the root vascular cylinder transfer cells used for nourishing, termed giant cells (GCs) and syncytia. Understanding the molecular mechanisms behind this process is essential to develop tools for nematode control. Based on the crucial role in gall development of \u003ci\u003eLBD16\u003c/i\u003e, also a key component of the auxin pathway leading to the divisions in the xylem pole pericycle during lateral root (LR) formation, we investigated genes co-regulated with \u003ci\u003eLBD16\u003c/i\u003e in different transcriptomes and analyzed their similarities and differences with those of RKNs and CNs feeding sites (FS). This analysis confirmed \u003ci\u003eLBD16\u003c/i\u003e and its co-regulated genes, integrated in signaling cascades mediated by auxins during LR and callus formation, as a particular feature of RKN-FS distinct to CNs. However, \u003ci\u003eLBD16\u003c/i\u003e, and its positively co-regulated genes, were repressed in syncytia, suggesting a selective down- regulation of the \u003ci\u003eLBD16\u003c/i\u003e auxin mediated pathways in CNs-FS. Interestingly, cytokinin-induced genes are enriched in syncytia and we encountered similarities between the transcriptome of shoot regeneration from callus, modulated by cytokinins, and that of syncytia. These findings establish differences in the regulatory networks leading to both FS formation, probably modulated by the auxin/cytokinin balance.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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