{"data":{"id":"10.6084/m9.figshare.1300170.v5","type":"dois","attributes":{"doi":"10.6084/m9.figshare.1300170.v5","prefix":"10.6084","suffix":"m9.figshare.1300170.v5","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Karami, Sara","nameType":"Personal","givenName":"Sara","familyName":"Karami","affiliation":[],"nameIdentifiers":[]},{"name":"Andreotti, Gabriella","nameType":"Personal","givenName":"Gabriella","familyName":"Andreotti","affiliation":[],"nameIdentifiers":[]},{"name":"Liao, Linda M","nameType":"Personal","givenName":"Linda M","familyName":"Liao","affiliation":[],"nameIdentifiers":[]},{"name":"Pfeiffer, Ruth M","nameType":"Personal","givenName":"Ruth M","familyName":"Pfeiffer","affiliation":[],"nameIdentifiers":[]},{"name":"Weinstein, Stephanie J","nameType":"Personal","givenName":"Stephanie J","familyName":"Weinstein","affiliation":[],"nameIdentifiers":[]},{"name":"Purdue, Mark P","nameType":"Personal","givenName":"Mark P","familyName":"Purdue","affiliation":[],"nameIdentifiers":[]},{"name":"Hofmann, Jonathan N","nameType":"Personal","givenName":"Jonathan N","familyName":"Hofmann","affiliation":[],"nameIdentifiers":[]},{"name":"Albanes, Demetrius","nameType":"Personal","givenName":"Demetrius","familyName":"Albanes","affiliation":[],"nameIdentifiers":[]},{"name":"Mannisto, Satu","nameType":"Personal","givenName":"Satu","familyName":"Mannisto","affiliation":[],"nameIdentifiers":[]},{"name":"Moore, Lee E","nameType":"Personal","givenName":"Lee E","familyName":"Moore","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"LINE1 methylation levels in pre-diagnostic leukocyte DNA and future renal cell carcinoma risk"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"111714 Mental Health","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Health sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Science Policy"},{"subject":"Cancer"},{"subject":"Biotechnology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"}],"contributors":[],"dates":[{"date":"2015-10-20","dateType":"Created"},{"date":"2016-01-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"Dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/15592294.2015.1006505","relatedIdentifierType":"DOI"},{"relationType":"IsPreviousVersionOf","relatedIdentifier":"10.6084/m9.figshare.1300170","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["91136 Bytes"],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Higher levels of LINE1 methylation in blood DNA have been associated with increased kidney cancer risk using post-diagnostically collected samples; however, this association has never been examined using pre-diagnostic samples. We examined the association between LINE1 %5mC and renal cell carcinoma (RCC) risk using pre-diagnostic blood DNA from the United States-based, Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) (215 cases/436 controls), and the Alpha-tocopherol, Beta-carotene Cancer Prevention Study (ATBC) of Finnish male smokers (191 cases/575 controls). Logistic regression adjusted for age at blood draw, study center, pack-years of smoking, body mass index, hypertension, dietary alcohol intake, family history of cancer, and sex was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) using cohort and sex-specific methylation categories. In PLCO, higher, although non-significant, RCC risk was observed for participants at or above median methylation level (M2) compared to those below the median (M1) (OR: 1.37, 95% CI: 0.96–1.95). The association was stronger in males (M2 vs. M1, OR: 1.54, 95% CI: 1.00–2.39) and statistically significant among male smokers (M2 vs. M1, OR: 2.60, 95% CI: 1.46–4.63). A significant interaction for smoking was also detected (\u003ci\u003eP\u003c/i\u003e-interaction: 0.01). No association was found among females or female smokers. Findings for male smokers were replicated in ATBC (M2 vs. M1, OR: 1.31, 95% CI: 1.07–1.60). In a pooled analysis of PLCO and ATBC male smokers (281cases/755controls), the OR among subjects at or above median methylation level (M2) compared to those below the median (M1) was 1.89 (95% CI: 1.34–2.67, \u003ci\u003eP\u003c/i\u003e-value: 3 x 10\u003csup\u003e–4\u003c/sup\u003e); a trend was also observed by methylation quartile (\u003ci\u003eP\u003c/i\u003e-trend: 0.002). These findings suggest that higher LINE1 methylation levels measured prior to cancer diagnosis may be a biomarker of future RCC risk among male smokers.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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